Original Paper

AIDS and Behavior

, Volume 18, Issue 12, pp 2409-2422

First online:

ACT2 Peer-Driven Intervention Increases Enrollment into HIV/AIDS Medical Studies Among African Americans/Blacks and Hispanics: A Cluster Randomized Controlled Trial

  • Marya GwadzAffiliated withCenter for Drug Use and HIV Research, New York University College of Nursing Email author 
  • , Charles M. ClelandAffiliated withCenter for Drug Use and HIV Research, New York University College of Nursing
  • , Mindy BelkinAffiliated withCenter for Drug Use and HIV Research, New York University College of Nursing
  • , Amanda RitchieAffiliated withCenter for Drug Use and HIV Research, New York University College of Nursing
  • , Noelle LeonardAffiliated withCenter for Drug Use and HIV Research, New York University College of Nursing
  • , Marion RiedelAffiliated withSchool of Social Work, Columbia University
  • , Angela BanfieldAffiliated withCenter for Drug Use and HIV Research, New York University College of Nursing
  • , Pablo ColonAffiliated withCenter for Drug Use and HIV Research, New York University College of Nursing
  • , Vanessa ElharrarAffiliated withNational Institute of Allergy & Infectious Diseases, National Institutes of Health
    • , Jonathan KaganAffiliated withNational Institute of Allergy & Infectious Diseases, National Institutes of Health
    • , Donna MildvanAffiliated withDivision of Infectious Diseases, Mt. Sinai Beth Israel Medical Center
    • , ACT2 Collaborative Research Team

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Abstract

African American/Black and Hispanic persons living with HIV/AIDS (“AABH-PLHA”) are under-represented in HIV/AIDS medical studies (HAMS). This paper evaluates the efficacy of a social/behavioral intervention to increase rates of screening for and enrollment into HAMS in these populations. Participants (N = 540) were enrolled into a cluster randomized controlled trial of an intervention designed to overcome multi-level barriers to HAMS. Primary endpoints were rates of screening for and enrollment into therapeutic/treatment-oriented and observational studies. Intervention arm participants were 30 times more likely to be screened than controls (49.3 % vs. 3.7 %; p < .001). Half (55.5 %) of those screened were eligible for HAMS, primarily observational studies. Nine out of ten found eligible enrolled (91.7 %), almost all into observational studies (95.2 %), compared to no enrollments among controls. Achieving appropriate representation of AABH-PLHA in HAMS necessitates modification of study inclusion criteria to increase the proportion found eligible for therapeutic HAMS, in addition to social/behavioral interventions.

Keywords

Clinical trials HIV/AIDS African American Black Hispanic Minority Motivational Interviewing Health care disparities