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Predictors of Screening for AIDS Clinical Trials Among African-Americans and Latino/Hispanics Enrolled in an Efficacious Peer-Driven Intervention: Uncovering Socio-Demographic, Health, and Substance Use-Related Factors That Promote or Impede Screening

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Abstract

African-American and Latino/Hispanic persons living with HIV/AIDS are underrepresented in AIDS clinical trials (ACTs). The aim of this paper was to uncover factors, either unmodifiable or not directly targeted for change, that predicted screening for ACTs during an efficacious peer-driven intervention (N = 540 total; N = 351 in an intervention arm, N = 189 control). This paper focused on participants assigned to an intervention arm, 56 % of whom were screened for ACTs. We found a decreased odds of screening was associated with closer proximity to the screening site, gay/lesbian orientation, lower mental health symptoms, current injection drug use, more recent HIV diagnosis, lack of prior screening experience, and failure to attend all intervention sessions, but there were no gender or racial/ethnic differences. Efforts to reduce racial/ethnic disparities in ACTs can be enhanced by attending to these specific factors, which may interfere with programmatic efforts to increase African-American and Latino/Hispanic representation in ACTs.

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Acknowledgments

Funding for this study was provided by the National Institute of Allergy and Infectious Diseases (R01 AI070005) and the Center for Drug Use and HIV Research (P30 DA011041) at the New York University College of Nursing. The project is dedicated to the memory of Keith Cylar, co-founder and co-chief executive officer of Housing Works (1958–2004), and former Housing Works principal investigator of the ACT1 Project, upon which the ACT2 study is based. We would like to acknowledge the men and women who participated in the ACT2 Project; Usha Sharma, Ph.D., the study’s Program Officer at the Division of AIDS, NIAID, NIH, and Vanessa Elharrar, M.D., the study’s Medical Officer at the Division of AIDS, NIAID, NIH; Jonathan Kagan, Ph.D. at NIAID, NIH; and members of the ACT2 Collaborative Research Team: Michael Aguirre, Mindy Belkin, MA, Noreen Boadi, MA, DeShannon Bowens, MA, Patricia Chang, MA, Pablo Colon, DPM, Gwen Costantini, FNP-C, Rebecca de Guzman, ABD, Ann Marshak, Sondra Middleton, PA-C, Corinne Munoz-Plaza, MPH, Maya Tharaken, MSSW, Robert Quiles, and Mougeh Yasai, MA.

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Authors and Affiliations

  1. Center for Drug Use and HIV Research, New York University College of Nursing, 726 Broadway, 10th Floor, New York, NY, 10003, USA

    Marya Gwadz, Charles M. Cleland, Noelle R. Leonard, Amanda S. Ritchie, Angela Banfield & Pablo Colon

  2. School of Social Work, Columbia University, New York, NY, USA

    Marion Riedel

  3. Division of Infectious Diseases, Beth Israel Medical Center, New York, NY, USA

    Donna Mildvan

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  1. Marya Gwadz
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Correspondence to Marya Gwadz.

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Gwadz, M., Cleland, C.M., Leonard, N.R. et al. Predictors of Screening for AIDS Clinical Trials Among African-Americans and Latino/Hispanics Enrolled in an Efficacious Peer-Driven Intervention: Uncovering Socio-Demographic, Health, and Substance Use-Related Factors That Promote or Impede Screening. AIDS Behav 17, 801–812 (2013). https://doi.org/10.1007/s10461-012-0194-1

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