Annals of Biomedical Engineering

, Volume 42, Issue 7, pp 1413-1423

First online:

Microstructured Extracellular Matrices in Tissue Engineering and Development: An Update

  • Joe TienAffiliated withDepartment of Biomedical Engineering, Boston UniversityDivision of Materials Science and Engineering, Boston University Email author 
  • , Celeste M. NelsonAffiliated withDepartment of Chemical and Biological Engineering, Princeton UniversityDepartment of Molecular Biology, Princeton University Email author 

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access


Microstructured extracellular matrix (ECM), which contains heterogeneous features of the same size scale (5–100 μm) as tissue organoids, has become an important material for the engineering of functional tissues and for the study of tissue-level biology. This review describes methods to generate this class of ECM, and highlights recent advances in the application of microstructured ECM to problems in basic and applied biology. It also discusses computational techniques to analyze and optimize the microstructural patterns for a desired functional output.


Biomimicry Bio-inspired design Micropatterning Soft lithography Multi-scale biomaterials