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Impact of photodynamic therapy on quality of life of patients with age-related macular degeneration in Korea

  • Clinical Investigation
  • Published:
Japanese Journal of Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To assess quality of life (QOL) changes in patients with age-related macular degeneration (AMD) before and after treatment with photodynamic therapy (PDT).

Methods

In 625 patients with AMD, the EuroQol Health Questionnaire (EQ-5D) for general health status and the Visual Function Questionnaire (VF-4D) for vision-related reading ability, independence, and fear for the future were used and the results compared between within 1 week before PDT and 1 year after PDT. Subscale QOL changes were also scored with the Korean versions of EQ-5D and VF-4D.

Results

EQ-5D scores of male patients were higher than those of female patients (P < 0.05), and scores of unilateral patients were higher than those of bilateral patients (P < 0.001). Among all patients, 41.2% had a higher EQ-5D score after PDT. The mean differences between before and after treatment, estimated by three different models, the Korean model, the UK model, and the Japanese model, were all statistically significant (P < 0.001). Utility measured by the VF-4D score after PDT increased by 16.1% (P < 0.001), and subscale utilities indicated significant improvements in fear for the future (21.1%), reading ability (16.6%–14.5%), and independence (11.6%).

Conclusions

PDT for patients with AMD improved both general health-related QOL and vision-related QOL, as well as subscale scores, as evaluated by EQ-5D and VF-4D.

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Authors and Affiliations

  1. College of Nursing, Seoul National University, Seoul, Republic of Korea

    Jinhyun Kim

  2. Department of Ophthalmology, Kyung Hee University Hospital, Kyung Hee University School of Medicine, Seoul, Republic of Korea

    Hyung Woo Kwak

  3. Department of Ophthalmology, Seoul St. Mary’s Hospital, Catholic University Medical School, Seoul, Republic of Korea

    Won Ki Lee

  4. Department of Ophthalmology, Kangnam Sacred Heart Hospital, Hallym University Medical School, Seoul, Republic of Korea

    Ha Kyoung Kim

  5. Kangnam Sacred Heart Hospital, 948-1 Daerim-dong, Youngdeungpo-gu, Seoul, 150-950, Republic of Korea

    Ha Kyoung Kim

Authors
  1. Jinhyun Kim
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  2. Hyung Woo Kwak
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  3. Won Ki Lee
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  4. Ha Kyoung Kim
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Correspondence to Ha Kyoung Kim.

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Kim, J., Kwak, H.W., Lee, W.K. et al. Impact of photodynamic therapy on quality of life of patients with age-related macular degeneration in Korea. Jpn J Ophthalmol 54, 325–330 (2010). https://doi.org/10.1007/s10384-010-0825-x

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  • DOI: https://doi.org/10.1007/s10384-010-0825-x

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