Skip to main content

Advertisement

SpringerLink
Log in

Inhibitory control task is decreased in vascular incontinence patients

  • Research Article
  • Published:
Clinical Autonomic Research Aims and scope Submit manuscript

Abstract

Objective

‘Vascular incontinence’ is a part of elderly incontinence due to cerebral white matter change (WMC). We studied the relationship between performance on several cognitive tasks and urodynamic detrusor overactivity (DO) in patients with vascular incontinence.

Methods

We recruited 40 patients with lower urinary tract symptoms due to WMC [20 male, 20 female; mean age 77 years (60–89 years)]. Other neurologic, urologic, and systemic causes of LUT dysfunction were excluded. All patients underwent urodynamics tests and two sets of cognitive tasks, i.e., the Mini-Mental State Examination (MMSE) (general cognitive tasks), and the Frontal Assessment Battery (FAB) (frontal lobe tasks).

Results

The most common urinary symptom was urinary urgency (27 patients), followed by urinary incontinence (26) and nocturnal urinary frequency (25). The urodynamic testing revealed DO in 22 patients. The cognitive testing revealed that the patients’ mean MMSE score was 25.8 (range 15–30), and their mean FAB score was 13.6 (4–18). There was no relationship between DO and the total MMSE or FAB score, but our analysis of the relationship between DO and the six subdomains of the FAB (conceptualization, mental flexibility, programming, sensitivity to interference, inhibitory control, and environmental autonomy) revealed a significant relationship between DO and the inhibitory control task (p < 0.005).

Conclusions

The results of the present study showed that performance on an inhibitory control task is decreased in vascular incontinence patients with DO.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Milsom I, Abrams P, Cardozo L et al (2001) How widespread are the symptoms of an overactive bladder and how are they managed? A population-based prevalence study. BJU Int 87:760–766

    Article  PubMed  CAS  Google Scholar 

  2. Stewart WF, Van Rooyen JB, Cundiff GW et al (2003) Prevalence and burden of overactive bladder in the United States. World J Urol 20:327–336

    PubMed  CAS  Google Scholar 

  3. Homma Y, Yamaguchi O, Hayashi K et al (2005) An epidemiological survey of overactive bladder symptoms in Japan. BJU Int 96:1314–1318

    Article  PubMed  Google Scholar 

  4. Elbadawi A, Hailemariam S, Yalla SV et al (1997) Structural basis of geriatric voiding dysfunction. VII. Prospective ultrastructural/urodynamic evaluation of its natural evolution. J Urol 157:1814–1822

    Article  PubMed  CAS  Google Scholar 

  5. Fowler CJ, Griffiths D, de Groat WC (2008) The neural control of micturition. Nat Rev Neurosci 9:453–466

    Article  PubMed  CAS  Google Scholar 

  6. Sakakibara R, Hattori T, Uchiyama T et al (1999) Urinary function in the elderly with and without leukoaraiosis; in relation to cognitive and gait function. J Neurol Neurosurg Psychiatry 67:658–660

    Article  PubMed  CAS  Google Scholar 

  7. Kuchel GA, Moscufo N, Guttmann CR et al (2009) Localization of brain white matter hyperintensities and urinary incontinence in community-dwelling older adults. J Gerontol A Biol Sci Med Sci 64:902–909

    Article  PubMed  Google Scholar 

  8. Tadic SD, Griffiths D, Murrin A et al (2010) Brain activity during bladder filling is related to white matter structural changes in older women with urinary incontinence. Neuroimage 51:1294–1302

    Article  PubMed  Google Scholar 

  9. Brant-Zawadzki M, Fein G, Van Dyke C et al (1985) MR imaging of the aging brain; patchy white-matter lesions and dementia. AJNR 6:675–682

    PubMed  CAS  Google Scholar 

  10. Abrams P, Cardozo L, Fall M et al (2002) The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society. Neurourol Urodyn 21:167–178

    Article  PubMed  Google Scholar 

  11. Folstein M, Folstein S, McHugh PR (1975) Mini-mental state; a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12:189–198

    Article  PubMed  CAS  Google Scholar 

  12. Dubois B, Slachevsky A, Litvan I et al (2000) The FAB. A frontal assessment battery at bedside. Neurology 55:1621–1626

    Article  PubMed  CAS  Google Scholar 

  13. Del-Ser T, Munoz DG, Hachinski V (1996) Temporal pattern of cognitive decline and incontinence is different in Alzheimer’s disease and diffuse Lewy body disease. Neurology 46:682–686

    Article  PubMed  CAS  Google Scholar 

  14. Hentschel F, Damian M, Krumm B et al (2007) White matter lesions—age-adjusted values for cognitively healthy and demented subjects. Acta Neurol Scand 115:174–180

    Article  PubMed  CAS  Google Scholar 

  15. Mok V, Wong KK, Xiong Y et al (2011) Cortical and frontal atrophy are associated with cognitive impairment in age-related confluent white-matter lesion. J Neurol Neurosurg Psychiatry 82:52–57

    Article  PubMed  Google Scholar 

  16. Tullberg M, Fletcher E, DeCarli C et al (2004) White matter lesions impair frontal lobe function regardless of their location. Neurology 63:246–253

    Article  PubMed  CAS  Google Scholar 

  17. Hanyu H, Shimuzu S, Tanaka Y et al (2004) Cerebral blood flow patterns in Binswanger’s disease: a SPECT study using three-dimensional stereotactic surface projections. J Neurol Sci 220:79–84

    Article  PubMed  Google Scholar 

  18. Yamanouchi H, Nagura H (1997) Neurological signs and frontal white matter lesions in vascular Parkinsonism. A clinicopathologic study. Stroke 28:965–969

    Article  PubMed  CAS  Google Scholar 

  19. Mok VC, Wong A, Yim P et al (2004) The validity and reliability of Chinese frontal assessment battery in evaluating executive dysfunction among Chinese patients with small subcortical infarct. Alzheimer Dis Assoc Disord 18:68–74

    Article  PubMed  Google Scholar 

  20. Zago-Gomes MDP, Nakamura-Palacios EM (2009) Cognitive components of frontal lobe function in alcoholics classified according to Lesch’s typology. Alcohol Alcohol 44:449–457

    Article  Google Scholar 

  21. Yamao A, Nagata T, Shinagawa S et al (2011) Differentiation between amnestic-mild cognitive impairment and early-stage Alzheimer’s disease using the Frontal Assessment Battery test. Psychogeriatrics 11:235–241

    Article  PubMed  Google Scholar 

  22. Sakagami M, Pan X, Uttl B (2006) Behavioral inhibition and prefrontal cortex in decision-making. Neural Netw 19:1255–1265

    Article  PubMed  Google Scholar 

  23. Declerck CH, Boone C, De Brabander B (2006) On feeling in control: a biological theory for individual differences in control perception. Brain Cogn 62:143–176

    Article  PubMed  Google Scholar 

Download references

Conflict of interest

None of the authors have any conflict of interest relevant to the study.

Ethics approval

Ethics approval was provided by the Ethical Committee of Sakura Medical Center, Toho University, Japan.

Author information

Authors and Affiliations

  1. Neurology, Internal Medicine, Sakura Medical Center, Toho University, 564-1 Shimoshizu, Sakura, 285-8741, Japan

    Hiroyuki Haruta, Ryuji Sakakibara, Clare J. Fowler, Fuyuki Tateno & Masahiko Kishi

  2. Uro-Neurology, National Hospital for Neurology & Neurosurgery, Queen Square, London, UK

    Tsuyoshi Ogata & Jalesh Panicker

  3. Neurology, Chiba University, Chiba, Japan

    Yohei Tsuyusaki, Tomoyuki Uchiyama & Tatsuya Yamamoto

Authors
  1. Hiroyuki Haruta
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ryuji Sakakibara
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Tsuyoshi Ogata
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jalesh Panicker
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Clare J. Fowler
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Fuyuki Tateno
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Masahiko Kishi
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Yohei Tsuyusaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Tomoyuki Uchiyama
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Tatsuya Yamamoto
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ryuji Sakakibara.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Haruta, H., Sakakibara, R., Ogata, T. et al. Inhibitory control task is decreased in vascular incontinence patients. Clin Auton Res 23, 85–89 (2013). https://doi.org/10.1007/s10286-013-0187-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10286-013-0187-9

Keywords

Search

Navigation