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Serum antibodies against the 70k polypeptides of the U1 ribonucleoprotein complex are associated with psychiatric syndromes in systemic lupus erythematosus: a retrospective study

  • Original Article
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Modern Rheumatology

Abstract

Objectives

We assessed the association between serum autoantibodies against the 70-kDa polypeptide of the U1-ribonucleoprotein (RNP) complex (U1-70k) and the central nervous system (CNS) syndromes in systemic lupus erythematosus (SLE) patients.

Methods

We studied 106 hospitalized patients with active SLE, comparing those with (n = 32) and without (n = 74) CNS syndromes. CNS syndromes were further classified into neurologic (n = 21) and psychiatric (n = 15) disorders. Immunoglobulin G (IgG) anti-U1-70k antibodies were measured by enzyme-linked immunosorbent assay (ELISA) using recombinant antigens. IgG antibodies against whole U1-RNP were measured using commercial ELISA kits.

Results

Although there was no significant difference in the levels of serum anti-U1-70k antibodies in SLE patients with or without CNS syndromes (p = 0.83), the levels were significantly elevated in SLE patients compared with patients without psychiatric syndromes (p = 0.030). In contrast, no significant difference was observed in the levels of serum anti-U1-RNP antibodies in SLE patients with or without psychiatric syndromes (p = 0.555).

Conclusions

These results indicate that serum anti-U1-70k antibodies are associated with psychiatric syndromes in SLE but that they are not associated with CNS syndromes as a whole or with neurologic syndromes. The anti-U1-70k antibodies might be involved in the pathological mechanisms of psychiatric syndromes in SLE.

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Acknowledgments

We thank Dr. Katsuji Nishimura (Department of Psychiatry, Tokyo Women’s Medical University) for assisting with the psychological examinations and diagnoses and Professor Shinichiro Uchiyama (Department of Neurology, Neurological Institute, Tokyo Women’s Medical University) for assisting with the neurological examinations and diagnoses. This work was supported by a grant from the Japanese Ministry of Health, Labor, and Welfare (Grant for Intractable Diseases).

Conflict of interest

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Authors and Affiliations

  1. Institute of Rheumatology, Tokyo Women’s Medical University, 10-22 Kawada-cho, Shinjuku-ku, Tokyo, 162-0054, Japan

    Yasuhiro Katsumata, Yasushi Kawaguchi, Sayumi Baba, Yuko Okamoto, Hisashi Yamanaka & Masako Hara

  2. Division of Cellular Proteomics (BML), Institute of Medical Science, University of Tokyo, Tokyo, Japan

    Seisuke Hattori

  3. Division of Biochemistry, School of Pharmaceutical Science, Kitasato University, Tokyo, Japan

    Seisuke Hattori

  4. Advanced Medical Technology and Development, BML, Saitama, Japan

    Koji Tahara, Kaori Ito, Tadao Iwasaki, Nozomi Yamaguchi, Hiroaki Hattori & Kinya Nagata

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  1. Yasuhiro Katsumata
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Correspondence to Yasuhiro Katsumata.

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Katsumata, Y., Kawaguchi, Y., Baba, S. et al. Serum antibodies against the 70k polypeptides of the U1 ribonucleoprotein complex are associated with psychiatric syndromes in systemic lupus erythematosus: a retrospective study. Mod Rheumatol 23, 71–80 (2013). https://doi.org/10.1007/s10165-012-0624-y

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  • DOI: https://doi.org/10.1007/s10165-012-0624-y

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