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Clinical and serological associations of anti-ribosomal P0 protein antibodies in systemic lupus erythematosus

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Abstract

The purpose of this study is to investigate the clinical and serological associations of anti-ribosomal P0 protein antibodies (anti-Rib-P0) in patients with systemic lupus erythematosus (SLE). The sera of 470 patients with SLE and 124 patients with primary Sjogren’s Syndrome (pSS) were collected. Line immunoassay (LIA) was used to detect anti-Rib-P0 and other related antibodies. A complete laboratory evaluation and clinical examination were also performed in each SLE patient. The prevalence of anti-Rib-P0 in SLE patients was significantly higher than that in pSS patients (35.74 vs 6.45%) (P < 0.001). There was a significantly lower prevalence of cardiac involvement in anti-Rib-P0-positive SLE patients compared to anti-Rib-P0-negative SLE patients (P = 0.019); no significant associations of anti-Rib-P0 antibodies with encephalopathy manifestations and other vital organs involvement were observed. Anti-nucleosomes, anti-dsDNA, anti-Histones, anti-SmD1, and anti-U1snRNP were significantly associated with serum anti-Rib-P0 antibodies positivity in SLE patients (all P < 0.05). The sensitivity and specificity of the anti-Rib-P0 antibodies to diagnose SLE were 35.74 and 93.55%, respectively. There is a higher prevalence of anti-Rib-P0 in SLE patients. Anti-Rib-P0 positivity may indicate lower cardiac involvement for SLE patients. It may serve as an important complementary parameter in SLE, in addition to anti-dsDNA, anti-SmD1, and anti-nucleosomes.

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Acknowledgements

This work was supported by grants from the National Natural Science Foundation of China (81573222).

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  1. Yong-Jun Mei and Peng Wang contributed equally to this work.

Authors and Affiliations

  1. Department of Rheumatology and Immunology, The First Affiliated Hospital of Bengbu Medical College, 287 Changhuai Road, Bengbu, Anhui, 233004, China

    Yong-Jun Mei, Chao Jiang, Tao Wang, Lin-Jie Chen & Zhi-Jun Li

  2. Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China

    Peng Wang & Hai-Feng Pan

  3. Anhui Province Key Laboratory of Anhui Medical University, 81 Meishan Road, Hefei, Anhui, 230032, China

    Peng Wang & Hai-Feng Pan

Authors
  1. Yong-Jun Mei
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  2. Peng Wang
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  4. Tao Wang
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Contributions

H.-F.P. and Z.-J.L. designed the study; Y.-J.M., P.W., C.J., T.W., and L.-J.C. performed the experiments; Y.-J.M. and P.W. collected and analyzed the data; Y.-J.M. wrote the paper; H.-F.P. reviewed the paper.

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Correspondence to Zhi-Jun Li or Hai-Feng Pan.

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Yong-Jun Mei and Peng Wang should be considered co-first authors.

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Mei, YJ., Wang, P., Jiang, C. et al. Clinical and serological associations of anti-ribosomal P0 protein antibodies in systemic lupus erythematosus. Clin Rheumatol 37, 703–707 (2018). https://doi.org/10.1007/s10067-017-3886-0

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  • DOI: https://doi.org/10.1007/s10067-017-3886-0

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