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Permacol™ collagen paste injection for the treatment of complex anal fistula: 1-year follow-up

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Abstract

Background

Optimal surgical treatment for anal fistula should result in healing of the fistula track and preserve anal continence. The aim of this study was to evaluate Permacol™ collagen paste (Covidien plc, Gosport, Hampshire, UK) injection for the treatment of complex anal fistulas, reporting feasibility, safety, outcome and functional results.

Methods

Between May 2013 and December 2014, 21 consecutive patients underwent Permacol paste injection for complex anal fistula at our institutions. All patients underwent fistulectomy and seton placement 6–8 weeks before Permacol™ paste injection. Follow-up duration was 12 months.

Results

Eighteen patients (85.7%) had a high transsphincteric anal fistula, and three female patients (14.3%) had an anterior transsphincteric fistula. Fistulas were recurrent in three patients (14.3%). Seven patients (33%) had a fistula with multiple tracts. After a follow-up of 12 months, ten patients were considered healed (overall success rate 47.6%). The mean preoperative FISI score was 0.33 ± 0.57 and 0.61 ± 1.02 after 12 months.

Conclusions

Permacol™ paste injection was safe and effective in some patients with complex anal fistula without compromising continence.

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Authors and Affiliations

  1. Proctological and Perineal Surgical Unit, Department of Gastroenterology, Cisanello University Hospital, Pisa, Italy

    B. Fabiani, C. Menconi, I. Giani, G. Toniolo & G. Naldini

  2. General, Emergency and Minimaly Invasive Surgery, Careggi University Hospital, largo Brambilla 3, 50134, Florence, Italy

    J. Martellucci

Authors
  1. B. Fabiani
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  2. C. Menconi
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  3. J. Martellucci
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  4. I. Giani
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  5. G. Toniolo
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  6. G. Naldini
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Corresponding author

Correspondence to J. Martellucci.

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The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all participants included in the study.

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Fabiani, B., Menconi, C., Martellucci, J. et al. Permacol™ collagen paste injection for the treatment of complex anal fistula: 1-year follow-up. Tech Coloproctol 21, 211–215 (2017). https://doi.org/10.1007/s10151-017-1590-3

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  • DOI: https://doi.org/10.1007/s10151-017-1590-3

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