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Previous bloodstream infections due to other pathogens as predictors of carbapenem-resistant Klebsiella pneumoniae bacteraemia in colonized patients: results from a retrospective multicentre study

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Abstract

Introduction: the purpose of this retrospective multicenter study was to assess whether the risk of developing bloodstream infections (BSI) due to carbapenem-resistant Klebsiella pneumoniae (CRKP) in colonized patients is influenced by the occurrence of BSI due to other pathogens. Methods: from January 2012 to March 2014, all patients with at least one rectal swab positive for CRKP and at least 30 days of previous hospital stay were included in the study. The primary outcome measure was CRKP BSI, defined as a time-to-event endpoint. The role of potential predictors was evaluated through univariable and multivariable Cox regression analyses, considering previous BSI as a time-dependent variable. Results: during the study period, 353 patients met the inclusion criteria. Thirty-seven developed a CRKP BSI (11%). A higher incidence of CRKP BSI was observed in presence rather than in absence of previous BSI. In the final multivariable model of risk factors for CRKP BSI, multisite colonization (hazard ratio [HR] 13.73, 95% confidence intervals [CI] 3.29–57.32, p < 0.001), ICU stay (HR 3.14, 95% CI 1.19–8.31, p = 0.021), and previous BSI (p = 0.026, with the overall effect being mainly due to Enterococcus spp. BSI vs absence of BSI, HR 6.62, 95% CI 2.11–20.79) were associated with the development of CRKP BSI, while an inverse association was observed for age (HR 0.98, 95% CI 0.95–1.00, p = 0.027). Conclusions: previous BSI due to other pathogens were associated with an increased risk of CRKP BSI that was independent of other factors in colonized patients with prolonged hospital exposure.

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Authors and Affiliations

  1. Infectious Diseases Unit, DIPMI, DISSAL, IRCCS San Martino-IST and University of Genoa, Genoa, Italy

    D. R. Giacobbe, V. Del Bono, L. Magnasco, C. Saffioti & C. Viscoli

  2. IRCCS San Martino University Hospital – IST, University of Genoa, L.go R. Benzi, 10, 16132, Genoa, Italy

    D. R. Giacobbe

  3. Clinical Epidemiology Unit, IRCCS AOU San Martino-IST, Genoa, Italy

    P. Bruzzi

  4. Department of Medical Sciences, University of Turin, Infectious Diseases, Turin, Italy

    S. Corcione, N. Pagani, C. S. Cardellino & F. G. De Rosa

  5. Infectious Diseases Unit, Department of Medical and Surgical Sciences, S. Orsola-Malpighi Hospital and University of Bologna, Bologna, Italy

    M. Giannella & P. Viale

  6. Microbiology Unit, DISC, IRCCS San Martino-IST and University of Genoa, Genoa, Italy

    A. Marchese & E. Coppo

  7. Section of Infectious Diseases, Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy

    A. E. Maraolo

  8. Operative Unit of Clinical Microbiology, S. Orsola-Malpighi Hospital, Bologna, Italy

    S. Ambretti

Authors
  1. D. R. Giacobbe
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  2. V. Del Bono
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  3. P. Bruzzi
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  4. S. Corcione
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  5. M. Giannella
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  6. A. Marchese
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  7. L. Magnasco
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  8. A. E. Maraolo
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  9. N. Pagani
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  10. C. Saffioti
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  11. S. Ambretti
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  12. C. S. Cardellino
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  13. E. Coppo
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  14. F. G. De Rosa
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  15. P. Viale
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  16. C. Viscoli
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on behalf of ISGRI-SITA (Italian Study Group on Resistant Infections of the Società Italiana Terapia Antinfettiva)

Corresponding author

Correspondence to D. R. Giacobbe.

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The authors declare no conflicts of interest relevant to this paper.

Ethical approval

All procedures performed were in accordance with the ethical standards of the institutional and/or national research committees and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Not required because of the retrospective nature of the study.

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Giacobbe, D.R., Del Bono, V., Bruzzi, P. et al. Previous bloodstream infections due to other pathogens as predictors of carbapenem-resistant Klebsiella pneumoniae bacteraemia in colonized patients: results from a retrospective multicentre study. Eur J Clin Microbiol Infect Dis 36, 663–669 (2017). https://doi.org/10.1007/s10096-016-2843-1

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  • DOI: https://doi.org/10.1007/s10096-016-2843-1

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