Abstract
Generalized joint hypermobility (GJH) and joint hypermobility syndrome (JHS) are gaining increased attention as potential sources of pain and injury. The aims of this study were to evaluate prevalence of GJH and JHS and to determine whether musculoskeletal injuries and symptoms commonly attributed to GJH and JHS were more common within a “healthy” college student population. The study involved a convenience sample of 267 college and graduate students, aged 17–26. GJH was assessed using the Beighton score with a cutoff of 5/9, while JHS was assessed using the Brighton criteria. Injury history and symptoms were assessed by recall. Prevalence of GJH was 26.2 % overall (females 36.7 %, males 13.7 %). Prevalence of JHS was 19.5 % overall (females 24.5 %, males 13.7 %). Injury rates were not significantly different for individuals who had GJH vs. those who did not have GJH. Individuals with JHS were significantly more likely to have had sprains, back pain, and stress fractures. Symptoms were no different between those with GJH and those who did not have GJH. However, individuals with JHS were significantly more likely to report clumsiness, easy bruising, and balance problems than those who did not have JHS. GJH and JHS were relatively common in this healthy college student population; GJH was not associated with increased incidence of injury or symptoms commonly attributed to JHS, but JHS was associated with increased incidence of some injuries and symptoms.
Similar content being viewed by others
References
Remvig L, Flycht L, Christensen KB, Juul-Kristensen B (2014) Lack of consensus on tests and criteria for generalized joint hypermobility, Ehlers-Danlos syndrome: hypermobile type and joint hypermobility syndrome. Am J Med Genet A 164a(3):591–596. doi:10.1002/ajmg.a.36402
Bird HA (2007) Joint hypermobility. Musculoskeletal Care 5(1):4–19. doi:10.1002/msc.91
Tinkle BT, Bird HA, Grahame R, Lavallee M, Levy HP, Sillence D (2009) The lack of clinical distinction between the hypermobility type of Ehlers-Danlos syndrome and the joint hypermobility syndrome (a.k.a. hypermobility syndrome). Am J Med Genet A 149a(11):2368–2370. doi:10.1002/ajmg.a.33070
Grahame R (2008) Hypermobility: an important but often neglected area within rheumatology. Nat Clin Pract Rheumatol 4(10):522–524. doi:10.1038/ncprheum0907
Russek LN (2014) Diagnosing and managing hypermobility syndrome. Today in PT. Available at http://ce.todayinpt.com/course/pt64/diagnosing-and-managing-hypermobility-syndrome-/. Accessed 8/12/2014
Simmonds JV, Keer RJ (2007) Hypermobility and the hypermobility syndrome. Man Ther 12(4):298–309. doi:10.1016/j.math.2007.05.001
Castori M, Dordoni C, Valiante M, Sperduti I, Ritelli M, Morlino S, Chiarelli N, Celletti C, Venturini M, Camerota F, Calzavara-Pinton P, Grammatico P, Colombi M (2014) Nosology and inheritance pattern(s) of joint hypermobility syndrome and Ehlers-Danlos syndrome, hypermobility type: a study of intrafamilial and interfamilial variability in 23 Italian pedigrees. Am J Med Genet A 164a(12):3010–3020. doi:10.1002/ajmg.a.36805
Beighton P, Grahame R, Bird H (2012) Hypermobility of Joints, 4th edn. Springer, London
Malfait F, Hakim AJ, De Paepe A, Grahame R (2006) The genetic basis of the joint hypermobility syndromes. Rheumatology (Oxford) 45(5):502–507. doi:10.1093/rheumatology/kei268
Pacey V, Tofts L, Wesley A, Collins F, Singh-Grewal D (2014) Joint hypermobility syndrome: a review for clinicians. J Paediatr Child Health. doi:10.1111/jpc.12731
Jacobs JW, da Silva JA (2014) Hypermobility syndromes from the clinician’s perspective: an overview. Acta Reumatol Port 39(2):124–136
Castori M, Morlino S, Celletti C, Ghibellini G, Bruschini M, Grammatico P, Blundo C, Camerota F (2013) Re-writing the natural history of pain and related symptoms in the joint hypermobility syndrome/Ehlers-Danlos syndrome, hypermobility type. Am J Med Genet A 161A(12):2989–3004. doi:10.1002/ajmg.a.36315
Castori M, Sperduti I, Celletti C, Camerota F, Grammatico P (2011) Symptom and joint mobility progression in the joint hypermobility syndrome (Ehlers-Danlos syndrome, hypermobility type). Clin Exp Rheumatol 29(6):998–1005
el-Shahaly HA, el-Sherif AK (1991) Is the benign joint hypermobility syndrome benign? Clin Rheumatol 10(3):302–307
Fikree A, Grahame R, Aktar R, Farmer AD, Hakim AJ, Morris JK, Knowles CH, Aziz Q (2014) A prospective evaluation of undiagnosed joint hypermobility syndrome in patients with gastrointestinal symptoms. Clin Gastroenterol Hepatol 12(10):1680–1687. doi:10.1016/j.cgh.2014.01.014, e1682
Grahame R, Bird HA, Child A (2000) The revised (Brighton 1998) criteria for the diagnosis of benign joint hypermobility syndrome (BJHS). J Rheumatol 27(7):1777–1779
Remvig L, Jensen DV, Ward RC (2007) Epidemiology of general joint hypermobility and basis for the proposed criteria for benign joint hypermobility syndrome: review of the literature. J Rheumatol 34(4):804–809
Acasuso-Diaz M, Collantes-Estevez E (1998) Joint hypermobility in patients with fibromyalgia syndrome. Arthritis Care Res 11(1):39–42
Ofluoglu D, Gunduz OH, Kul-Panza E, Guven Z (2006) Hypermobility in women with fibromyalgia syndrome. Clin Rheumatol 25(3):291–293. doi:10.1007/s10067-005-0040-1
Barron DF, Cohen BA, Geraghty MT, Violand R, Rowe PC (2002) Joint hypermobility is more common in children with chronic fatigue syndrome than in healthy controls. J Pediatr 141(3):421–425. doi:10.1067/mpd.2002.127496
Bulbena A, Agullo A, Pailhez G, Martin-Santos R, Porta M, Guitart J, Gago J (2004) Is joint hypermobility related to anxiety in a nonclinical population also? Psychosomatics 45(5):432–437. doi:10.1176/appi.psy.45.5.432
Soper K, Simmonds JV, Kaz Kaz H, Ninis N (2014) The influence of joint hypermobility on functional movement control in an elite netball population: a preliminary cohort study. Phys Ther Sport. doi:10.1016/j.ptsp.2014.07.002
Russek LN, Errico DM (2013) The prevalence of generalized joint laxity and joint hypermobility syndrome among female college athletes. J Orthop Sports Phys Ther 43(1):A5. doi:10.2519
Connelly E, Hakim A, Davenport S, Simmonds J (2015) A study exploring the prevalence of joint hypermobility syndrome in patients attending a musculoskeletal triage clinic. Physiother Prac Res 36(1):43–53
Russek L, Gardner S, Maguire K, Stevens C, Brown EZ, Jayawardana V, Mondal S (2014) A cross-sectional survey assessing sources of movement-related fear among people with fibromyalgia syndrome. Clin Rheumatol. doi:10.1007/s10067-014-2494-5
Clark CJ, Simmonds JV (2011) An exploration of the prevalence of hypermobility and joint hypermobility syndrome in Omani women attending a hospital physiotherapy service. Musculoskeletal Care 9(1):1–10. doi:10.1002/msc.184
Rombaut L, Malfait F, Cools A, De Paepe A, Calders P (2010) Musculoskeletal complaints, physical activity and health-related quality of life among patients with the Ehlers-Danlos syndrome hypermobility type. Disabil Rehabil 32(16):1339–1345. doi:10.3109/09638280903514739
Moriatis Wolf J, Cameron KL, Owens BD (2011) Impact of joint laxity and hypermobility on the musculoskeletal system. J Am Acad Orthop Surg 19(8):463–471
Ruemper A, Watkins K (2012) Correlations between general joint hypermobility and joint hypermobility syndrome and injury in contemporary dance students. J Dance Med Sci 16(4):161–166
McCormack M, Briggs J, Hakim A, Grahame R (2004) Joint laxity and the benign joint hypermobility syndrome in student and professional ballet dancers. J Rheumatol 31(1):173–178
Murray B, Yashar BM, Uhlmann WR, Clauw DJ, Petty EM (2013) Ehlers-Danlos syndrome, hypermobility type: a characterization of the patients’ lived experience. Am J Med Genet A 161A(12):2981–2988. doi:10.1002/ajmg.a.36293
Albayrak I, Yilmaz H, Akkurt HE, Salli A, Karaca G (2014) Is pain the only symptom in patients with benign joint hypermobility syndrome? Clin Rheumatol. doi:10.1007/s10067-014-2610-6
Grahame R (2009) Joint hypermobility syndrome pain. Curr Pain Headache Rep 13(6):427–433
Juul-Kristensen B, Rogind H, Jensen DV, Remvig L (2007) Inter-examiner reproducibility of tests and criteria for generalized joint hypermobility and benign joint hypermobility syndrome. Rheumatology (Oxford) 46(12):1835–1841. doi:10.1093/rheumatology/kem290
Beighton P, De Paepe A, Steinmann B, Tsipouras P, Wenstrup RJ (1998) Ehlers-Danlos syndromes: revised nosology, Villefranche, 1997. Ehlers-Danlos National Foundation (USA) and Ehlers-Danlos Support Group (UK). Am J Med Genet 77(1):31–37
Decoster LC, Bernier JN, Lindsay RH, Vailas JC (1999) Generalized joint hypermobility and its relationship to injury patterns among NCAA lacrosse players. J Athl Train 34(2):99–105
Collinge R, Simmonds JV (2009) Hypermobility, injury rate and rehabilitation in a professional football squad–a preliminary study. Phys Ther Sport 10(3):91–96. doi:10.1016/j.ptsp.2009.03.001
Decoster LC, Vailas JC, Lindsay RH, Williams GR (1997) Prevalence and features of joint hypermobility among adolescent athletes. Arch Pediatr Adolesc Med 151(10):989–992
Azma K, Mottaghi P, Hosseini A, Abadi HH, Nouraei MH (2014) Benign joint hypermobility syndrome in soldiers; what is the effect of military training courses on associated joint instabilities? J Res Med Sci 19(7):639–643
Konopinski MD, Jones GJ, Johnson MI (2012) The effect of hypermobility on the incidence of injuries in elite-level professional soccer players: a cohort study. Am J Sports Med 40(4):763–769. doi:10.1177/0363546511430198
Clinch J, Deere K, Sayers A, Palmer S, Riddoch C, Tobias JH, Clark EM (2011) Epidemiology of generalized joint laxity (hypermobility) in fourteen-year-old children from the UK: a population-based evaluation. Arthritis Rheum 63(9):2819–2827. doi:10.1002/art.30435
Tobias JH, Deere K, Palmer S, Clark EM, Clinch J (2013) Joint hypermobility is a risk factor for musculoskeletal pain during adolescence: findings of a prospective cohort study. Arthritis Rheum 65(4):1107–1115. doi:10.1002/art.37836
Gulbahar S, Sahin E, Baydar M, Bircan C, Kizil R, Manisali M, Akalin E, Peker O (2006) Hypermobility syndrome increases the risk for low bone mass. Clin Rheumatol 25(4):511–514. doi:10.1007/s10067-005-0103-3
Adib N, Davies K, Grahame R, Woo P, Murray KJ (2005) Joint hypermobility syndrome in childhood. A not so benign multisystem disorder? Rheumatology (Oxford) 44(6):744–750. doi:10.1093/rheumatology/keh557
Falkerslev S, Baago C, Alkjaer T, Remvig L, Halkjaer-Kristensen J, Larsen PK, Juul-Kristensen B, Simonsen EB (2013) Dynamic balance during gait in children and adults with generalized joint hypermobility. Clin Biomech (Bristol, Avon) 28(3):318–324. doi:10.1016/j.clinbiomech.2013.01.006
Rombaut L, Malfait F, De Wandele I, Thijs Y, Palmans T, De Paepe A, Calders P (2011) Balance, gait, falls, and fear of falling in women with the hypermobility type of Ehlers-Danlos syndrome. Arthritis Care Res (Hoboken) 63(10):1432–1439. doi:10.1002/acr.20557
Rombaut L, Scheper M, De Wandele I, De Vries J, Meeus M, Malfait F, Engelbert R, Calders P (2014) Chronic pain in patients with the hypermobility type of Ehlers-Danlos syndrome: evidence for generalized hyperalgesia. Clin Rheumatol. doi:10.1007/s10067-014-2499-0
Remvig L, Jensen DV, Ward RC (2007) Are diagnostic criteria for general joint hypermobility and benign joint hypermobility syndrome based on reproducible and valid tests? A review of the literature. J Rheumatol 34(4):798–803
Conflict of interest
All human subject research contained in this manuscripts was reviewed and approved by the Clarkson University Institutional Review Board, which adheres to ethical standards established by the Declaration of Helsinki.
The authors, Leslie Russek and Deanna Errico, have not received funding for this work, have no conflict of interest with any organization, and have full control of all primary data.
Author information
Authors and Affiliations
Corresponding author
Appendices
Appendix A
Appendix B
Rights and permissions
About this article
Cite this article
Russek, L.N., Errico, D.M. Prevalence, injury rate and, symptom frequency in generalized joint laxity and joint hypermobility syndrome in a “healthy” college population. Clin Rheumatol 35, 1029–1039 (2016). https://doi.org/10.1007/s10067-015-2951-9
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10067-015-2951-9