Abstract
The aim of this study was to determine the association of anti-Sm antibodies with clinical manifestations, comorbidities, and disease damage in a large multi-ethnic SLE cohort. SLE patients (per American College of Rheumatology criteria), age ≥16 years, disease duration ≤10 years at enrollment, and defined ethnicity (African American, Hispanic or Caucasian), from a longitudinal US cohort were studied. Socioeconomic-demographic features, cumulative clinical manifestations, comorbidities, and disease damage (as per the Systemic Lupus International Collaborating Clinics Damage Index [SDI]) were determined. The association of anti-Sm antibodies with clinical features was examined using multivariable logistic regression analyses adjusting for age, gender, ethnicity, disease duration, level of education, health insurance, and smoking. A total of 2322 SLE patients were studied. The mean (standard deviation, SD) age at diagnosis was 34.4 (12.8) years and the mean (SD) disease duration was 9.0 (7.9) years; 2127 (91.6 %) were women. Anti-Sm antibodies were present in 579 (24.9 %) patients. In the multivariable analysis, anti-Sm antibodies were significantly associated with serositis, renal involvement, psychosis, vasculitis, Raynaud’s phenomenon, hemolytic anemia, leukopenia, lymphopenia, and arterial hypertension. No significant association was found for damage accrual. In this cohort of SLE patients, anti-Sm antibodies were associated with several clinical features including serious manifestations such as renal, neurologic, and hematologic disorders as well as vasculitis.
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Funding
Supported by grants from the National Institute of Arthritis and Musculoskeletal and Skin Diseases: R01 AR064820 (University of Alabama Birmingham [UAB]—Coordinating Site, Johns Hopkins University [JHU], Northwestern University [NU], University of Puerto Rico [UPR], and University of Texas Health Science Center at Houston [UTH]), P01 AR49084 (UAB) AR43727 (JHU), R01 AR42503 (UAB), K24-AR002138 (NU), P60AR048098 (NU), P60AR064464 (NU), and R01-AR42503 (UTH); grants from the Center of Clinical & Translational Science: UL1 TR000165 (UAB) and 8UL1TR000150 (NU), and General Clinical Research Centers: M01-RR00052 (JHU), M01-RR00048 (NU), and M01-RR02558 (UTH); and the National Institute of Health and Health Disparities grant number 8U54MD007587 (UPR), and by an unrestricted educational grant from Abbvie (UPR).
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The Institutional Review Board of each institution approved this study, and written informed consent was obtained from all participating subjects according to the Declaration of Helsinki.
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Arroyo-Ávila, M., Santiago-Casas, Y., McGwin, G. et al. Clinical associations of anti-Smith antibodies in PROFILE: a multi-ethnic lupus cohort. Clin Rheumatol 34, 1217–1223 (2015). https://doi.org/10.1007/s10067-015-2941-y
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DOI: https://doi.org/10.1007/s10067-015-2941-y