Abstract
To investigate the association of anti-Sm antibodies with clinical and serological features in systemic lupus erythematosus. A group of 1,584 patients with SLE was recruited. Clinical and laboratory data were compared between patients with and without anti-Sm antibodies. There were 1,424 females and 160 males, the mean age of the patients was 33.2 ± 12.3 years, and the mean duration of disease was 32.5 ± 59.4 months. A total of 469 (29.6%) were anti-Sm antibodies positive. The presence of anti-Sm antibodies was associated with arthritis, renal involvement, malar rash, vasculitis and low serum complement C3. The positive rate of anti-nuclear, anti-dsDNA, anti-La/SSB and anti-U1RNP antibodies were significant higher in anti-Sm positive group when compared with anti-Sm negative group. A trend towards a higher presence of anti-Sm antibodies related to an early disease onset was observed. In conclusion, Anti-Sm antibodies are associated with lupus related clinical and laboratory profiles and correlated significantly with disease activity.
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Acknowledgments
This work was partly supported by grants from the National Natural Science Foundation of China (30571608, 30771848) and Natural Science Foundation of Anhui Province (070413109). We are indebted to Dr. Bo Ke Zhang, the First Affiliated Hospital of Anhui Medical University and Dr. Guo Sheng Wang, Anhui Provincial Hospital, for assistance in case identification; We also thank Hang Hong, Xiao Yue Chu, Bing Dai and Guo Ping Chen, students of Anhui Medical University, for assistance in data collection. Their cooperation was invaluable to this research.
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Ni, J.D., Yao, X., Pan, H.F. et al. Clinical and serological correlates of anti-Sm autoantibodies in Chinese patients with systemic lupus erythematosus: 1,584 cases. Rheumatol Int 29, 1323–1326 (2009). https://doi.org/10.1007/s00296-009-0855-1
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DOI: https://doi.org/10.1007/s00296-009-0855-1