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Poly-2-methoxyethylacrylate-coated cardiopulmonary bypass circuit can reduce transfusion of platelet products compared to heparin-coated circuit during aortic arch surgery

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  • Cardiopulmonary Bypass
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Abstract

Several coating techniques for extracorporeal circulation have been developed to reduce the systemic inflammatory response during cardiopulmonary bypass (CPB). We compared the clinical effectiveness and biocompatibility of poly-2-methoxyethylacrylate (PMEA)- and heparin-coated CPB circuits in total aortic arch replacement (TAR) with the prolonged use of the bypass technique. Twenty patients who underwent elective TAR were divided randomly into two equal groups: group P (n = 10) to use PMEA-coated circuits and group H (n = 10) to use heparin-coated circuits. Clinical outcomes, hematological variables, and acute phase inflammatory response were analyzed perioperatively. Demographic, CPB, and clinical outcome data were similar for both groups. Hemoglobin and platelet count showed similar time-course curves. However, the amount of platelet products transfused intraoperatively was significantly larger in group H (group P 26.0 ± 7.0 units; group H 33.0 ± 6.7 units, p = 0.04). Total protein, and albumin levels were significantly higher in group P during and after the operation (total protein, p = 0.04; albumin, p = 0.02). The use of PMEA-coated circuit is associated with retainment of perioperative plasma proteins levels and may help to reduce transfusion of platelet products in TAR in comparison with the heparin-coated circuit.

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    Authors and Affiliations

    1. Division of Cardiovascular Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryocho, Aoba-ku, Sendai, Japan

      Katsuhiro Hosoyama, Koki Ito, Shunsuke Kawamoto, Masatoshi Akiyama, Osamu Adachi, Satoshi Kawatsu & Yoshikatsu Saiki

    2. Research Division of Sciences for Aortic Disease, Tohoku University Graduate School of Medicine, Sendai, Japan

      Kiichiro Kumagai, Konosuke Sasaki & Marina Suzuki

    3. Division of Public Health, Tohoku University Graduate School of Medicine, Sendai, Japan

      Yumi Sugawara

    4. Department of Clinical Engineering, Division of Operation, Tohoku University Hospital, Sendai, Japan

      Yuya Shimizu

    Authors
    1. Katsuhiro Hosoyama
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    2. Koki Ito
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    3. Shunsuke Kawamoto
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    5. Masatoshi Akiyama
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    Correspondence to Katsuhiro Hosoyama.

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    Yoshikatsu Saiki received a research grant from Terumo Corporation, Tokyo, Japan. The other authors declare that they have no conflict of interest.

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    K. Hosoyama and K. Ito contributed to this manuscript equally.

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    Hosoyama, K., Ito, K., Kawamoto, S. et al. Poly-2-methoxyethylacrylate-coated cardiopulmonary bypass circuit can reduce transfusion of platelet products compared to heparin-coated circuit during aortic arch surgery. J Artif Organs 19, 233–240 (2016). https://doi.org/10.1007/s10047-016-0887-8

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    • DOI: https://doi.org/10.1007/s10047-016-0887-8

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