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Comparison and preparation of multilayered polylactic acid fabric strengthen calcium phosphate-based bone substitutes for orthopedic applications

  • Original Article
  • Biomaterials
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Abstract

An attempt to maintain the three-dimensional space into restorative sites through the conveniently pack porous fillers are general used strategy. Advancement in the manufacturing protective shells in the scaffolds, which would be filled with brittle ceramic grafts for the development of highly connective pores provides the approach to solve crack problem for generating the tissues. Therefore, multilayered braided and alkalized poly(lactic acid) (PLA) composites with calcium phosphate bone cement (CPC) were synthesized and compared. The PLA/CPC composites were divided into various groups according to a series of heat-treatment temperatures (100–190 °C) and periods (1–3 h) and then characterized. The effects of 24-h immersion on the strength decay resistance of the samples were compared. Results showed that the residual oil capped on the surfaces of alkalized PLA braid was removed, and the structure was unaltered. However, the reduced tensile stress of alkalized PLA braids was due to ester-group formation by hydrolysis. Mechanical test results of PLA/CPC composites showed that the strength significantly increased after heat treatment, except when the heating temperature was higher than the PLA melting point at approximately 160–170 °C. The degree of PLA after recrystallization became higher than that of unheated composites, thereby leading to reduced strength and toughness of the specimen. Braiding fibers of biodegradable PLA reinforced and toughened the structure particularly of the extra-brittle material of thin-sheet CPC after implantation.

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Acknowledgments

The authors acknowledge the financial support provided by the Ministry of Science and Technology, Taiwan, under contract number MOST 102&103-2622-E-035-006-CC2 and MOST103-2221-E-035-099-.

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    Authors and Affiliations

    1. Advanced Medical Devices and Composites Laboratory, Department of Fiber and Composite Materials, Feng Chia University, 100, Wenhwa Rd., Seatwen, Taichung, 40724, Taiwan

      Wen-Cheng Chen, Chia-Ling Ko, Jia-Kai Yang, Hui-Yu Wu & Jia-Horng Lin

    2. School of Chinese Medicine, China Medical University, Taichung, 40402, Taiwan

      Jia-Horng Lin

    3. Department of Biotechnology, Asia University, Taichung, 41354, Taiwan

      Jia-Horng Lin

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    1. Wen-Cheng Chen
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    Correspondence to Wen-Cheng Chen.

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    J.-H. Lin contributed equally.

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    Chen, WC., Ko, CL., Yang, JK. et al. Comparison and preparation of multilayered polylactic acid fabric strengthen calcium phosphate-based bone substitutes for orthopedic applications. J Artif Organs 19, 70–79 (2016). https://doi.org/10.1007/s10047-015-0863-8

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    • DOI: https://doi.org/10.1007/s10047-015-0863-8

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