Abstract
We present a case of sarcoma occurring at a site of resected oligodendroglioma without preceding radiotherapy or chemotherapy. Oligosarcoma occurring at sites of resected oligodendroglioma or anaplastic oligodendroglioma with sarcomatous components are rare. Although meningioma or sarcoma-like lesions are sometimes reported after glioma-targeted radiotherapy, those without preceding radiotherapy are quite rare. Moreover, cases of sarcoma without oligodendroglial components occurring at a site of resected oligodendroglioma have never been reported. In this case, fluorescent in situ hybridization analysis revealed 1p/19q co-deletion in both the first tumor and second tumors. Additionally, immunohistochemistry revealed mutated isocitrate dehydrogenase 1 in both tumors. Taken together, these findings suggest a monoclonal tumor origin. Consequently, this case may indicate a new mechanism of development of sarcomatous lesions occurring at the site of a resected glioma.
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Acknowledgments
This case was reported and discussed in clinicopathological conference at the 33rd Annual Meeting of the Japan Society of Brain Tumor Pathology on May 29, 30, 2015. We thank Dr. Gregory N. Fuller for his valuable comments on this case at the meeting.
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Shoji, T., Saito, R., Kanamori, M. et al. Sarcoma-like tumor originating from oligodendroglioma. Brain Tumor Pathol 33, 255–260 (2016). https://doi.org/10.1007/s10014-016-0268-2
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DOI: https://doi.org/10.1007/s10014-016-0268-2