Abstract
The purpose of the study was the analysis of cognitive functions in postmenopausal women having different status of homocysteine levels by a battery of computer tests—central nervous system vital signs (CNS-VS). We examined whether homocysteine increases the risk of cognitive decline and which cognitive domains are more affected. We showed that the considerably better neurocognitive index was obtained by women with low homocysteine levels in comparison with those with hyperhomocysteinemia (p = 0.0017). Similarly, results were obtained in the field of executive functioning (p = 0.0011), complex attention (p = 0.0106), cognitive flexibility (p = 0.0016), and memory (p = 0.0145). Verbal memory and visual memory did not differ considerably among the studied groups. Also, we demonstrated that ε4/ε4 genotype was the most common (15.5 %) in women with hyperhomocysteinemia than in groups of patients with low (0 %) or normal (1.9 %) homocysteine levels. In summary, hyperhomocysteinemia was related with increased risk of decline in executive functioning, complex attention, cognitive flexibility, and memory in postmenopausal women.
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Bojar I, Wojcik-Fatla A, Owoc A, Lewinski A (2012) Polymorphisms of apolipoprotein E gene and cognitive functions of postmenopausal women, measured by battery of computer tests—Central Nervous System Vital Signs. Neuro Endocrinol Lett 33(4):385–392
Castro R, Rivera I, Blom HJ, Jakobs C, Tavares de Almeida I (2006) Homocysteine metabolism, hyperhomocysteinaemia and vascular disease: an overview. J Inher Metab Dis 29:3–20
Chwatko G, Bald E (2002) Determination of different species of homocysteine in human plasma by high-performance liquid chromatography with ultraviolet detection. J Chromatogr A 949:141–151
Clarke R (2008) B-vitamins and prevention of dementia. Proc Nutr Soc 67:75–81
Dumas JA, Kutz AM, McDonald BC et al (2013) Increased working memory-related brain activity in middle-aged women with cognitive complaints. Neurobiol Aging 34(4):1145–1147
Elias MF, Robbins MA, Budge MM et al (2008) Homocysteine and cognitive performance: modification by the ApoE genotype. Neurosci Lett 430:64–69
Espeland MA, Shumaker SA, Leng I et al (2013) Long-term effects on cognitive function of postmenopausal hormone therapy prescribed to women aged 50 to 55 years. JAMA Intern Med 173(15):1429–1436
Giltay EJ, Verhoef P, Gooren LJ, Geleijnse JM, Schouten EG, Stehouwer CD (2003) Oral and transdermal estrogens both lower plasma total homocysteine in male-to-female transsexuals. Atherosclerosis 168:139–146
Gualtieri CT, Johnson LG (2006) Reliability and validity of computerized neurocognitive test battery, CNS Vital Signs. Arch Clin Neuropsychol 21:623–643
Hak AE, Polderman KH, Westendorp IC et al (2000) Increased plasma homocysteine after menopause. Atherosclerosis 149(1):163–168
Henderson VW (2008) Cognitive changes after menopause: influence of estrogen. Clin Obstet Gynecol 51(3):618–626
Henderson VW, Sherwin BB (2007) Surgical versus natural menopause: cognitive issues. Menopause 14:572–579
Jochemsen HM, Kloppenborg RP, de Groot LC et al (2013) Homocysteine, progression of ventricular enlargement, and cognitive decline: the Second Manifestations of ARTerial disease-Magnetic Resonance study. Alzheimers Dement 9(3):302–309
Kado DM, Karlamangla AS, Huang MH et al (2005) Homocysteine versus the vitamins folate, B6, and B12 as predictors of cognitive function and decline in older high-functioning adults: MacArthur Studies of Successful Aging. Am J Med 118:161–167
Li L, Cao D, Desmond R et al (2008) Cognitive performance and plasma levels of homocysteine, vitamin B12, folate, and lipids in patients with Alzheimer disease. Dement Geriatr Cogn Disord 26:384–390
Lin SK, Kao JT, Tsai SM (2004) Association of apolipoprotein E genotypes with serum lipid profiles in a healthy population of Taiwan. Am Clin Lab Sci 34:443–448
Lobo RA (2003) Homocysteine in women’s health. Menopause 10:271–273
Maki PM, Gast MJ, Vieweg AJ, Burriss SW, Yaffe K (2007) Hormone therapy in menopausal women with cognitive complaints: a randomized, double-blind trial. Neurology 69:1322–1330
McCaddon A (2006) Homocysteine and cognitive impairment: a case series in a General Practice setting. Nutr J 5:1–6
Morris MS (2012) The role of B vitamins in preventing and treating cognitive impairment and decline. Adv Nutr 3(6):801–812
Morris MS, Jacques PF, Rosenberg IH, Selhub J (2001) Hyperhomocysteinemia associated with poor recall in the third National Health and Nutrition Examination Survey. Am J Clin Nutr 73:927–933
Narayan SK, Saxby BK, Firbank MJ et al (2011) Plasma homocysteine and cognitive decline in older hypertensive subjects. Int Psychogeriatr 23:1607–1615
Nilsson K, Gustafson L, Nornholm M, Hultberg B (2010) Plasma homocysteine, apolipoprotein E status and vascular disease in elderly patients with mental illness. Clin Chem Lab Med 48(1):129–135
Nurk E, Refsum H, Tell GS et al (2005) Plasma total homocysteine and memory in the elderly: the Hordaland Homocysteine Study. Ann Neurol 58:847–857
Oveisgharan S, Hachinski V (2010) Hypertension, executive dysfunction and progression to dementia: the Canadian Study of Health and Aging. Arch Neurol 67:187–192
Phillips SM, Sherwin BB (1992) Effects of estrogen on memory function in surgically menopausal women. Psychoneuroendocrinology 17:485–495
Refsum H, Smith AD, Ueland PM et al (2004) Facts and recommendations about total homocysteine determinations: an expert opinion. Clin Chem 50:3–32
Sachdev PS, Valenzuela MJ, Brodaty H (2003) Homocysteine as a risk factor for cognitive impairment in stroke patients. Dement Geriatr Cogn Disord 15:155–62
Shaywitz SE, Shaywitz BA, Pugh KR (1999) Effect of estrogen on brain activation patterns in postmenopausal women during working memory tasks. JAMA 281:1197–1202
Tucker KL, Qiao N, Scott T, Rosenberg I, Spiro A (2005) High homocysteine and low B vitamins predict cognitive decline in aging men: the Veterans Affairs Normative Aging Study. Am J Clin Nutr 82:627–635
van den Kommer TN, Dik MG, Comijs HC, Jonker C, Deeg DJ (2010) Homocysteine and inflammation: predictors of cognitive decline in older persons? Neurobiol Aging 31:1700–1709
Wouters MG, Moorrees MT, van der Mooren MJ et al (1995) Plasma homocysteine and menopausal status. Eur J Clin Invest 25:801–805
Yang YG, Kim JY, Park SJ, Kim SW, Jeon OH, Kim DS (2007) Apolipoprotein E genotyping by multiplex tetra-primer amplification refractory mutation system PCR in single reaction tube. J Biotech 131:106–110
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Raszewski, G., Loroch, M., Owoc, A. et al. Homocysteine and cognitive disorders of postmenopausal women measured by a battery of computer tests—central nervous system vital signs. Arch Womens Ment Health 18, 623–630 (2015). https://doi.org/10.1007/s00737-015-0518-z
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DOI: https://doi.org/10.1007/s00737-015-0518-z