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Voltammetric and amperometric determination of selected catecholamine metabolites using glassy carbon paste electrode

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Abstract

Two methods, using glassy carbon paste electrode for the simultaneous determination homovanillic acid and vanillylmandelic acid, of two catecholamine neurotransmitter metabolites that can serve as biomarkers of several oncological diseases, were developed, based on differential pulse voltammetry and HPLC with amperometric detection. Low selectivity of the voltammetric method was limiting for the determination in urine samples; inclusion of chromatographic separation enabled the application in complex matrix.

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Acknowledgements

Financial support from the Czech Science Foundation (Project P206/15/02815S) is gratefully acknowledged.

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Authors and Affiliations

  1. Faculty of Science, Department of Analytical Chemistry, UNESCO Laboratory of Environmental Electrochemistry, Charles University, Albertov 6, 128 43, Prague 2, Czech Republic

    Hana Dejmkova, Hana Adamkova, Jiri Barek & Jiri Zima

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  1. Hana Dejmkova
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  2. Hana Adamkova
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  3. Jiri Barek
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  4. Jiri Zima
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Correspondence to Hana Dejmkova.

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Dejmkova, H., Adamkova, H., Barek, J. et al. Voltammetric and amperometric determination of selected catecholamine metabolites using glassy carbon paste electrode. Monatsh Chem 148, 511–515 (2017). https://doi.org/10.1007/s00706-016-1902-8

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  • DOI: https://doi.org/10.1007/s00706-016-1902-8

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