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The incidence rate and prevalence of pediatric type 1 diabetes mellitus (age 0–18) in the Italian region Friuli Venezia Giulia: population-based estimates through the analysis of health administrative databases

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Abstract

Aims

The main objective of this study was to estimate the incidence rate and prevalence of pediatric type 1 diabetes mellitus (T1DM; population 0–18 years of age) in the northeastern Italian region Friuli Venezia Giulia and to characterize the subjects affected by the disease.

Methods

This was a retrospective population-based study conducted through the individual-level linkage of several health administrative databases of the Friuli Venezia Giulia region. The incidence rate and prevalence were calculated in the population 0–18 years of age. Using the Mid-p exact method, 95 % confidence intervals for rates were calculated.

Results

The incidence rate of pediatric T1DM in the years 2010–2013 was 15.8 new cases/100,000 person-years, peaking in the age class 10–14 years. The rate has increased substantially as compared with the previous regional estimate that dated back to 1993. We observed a seasonal pattern both in the date of birth of the incident cases and in the date of onset of the disease. In the region in 2013, there were 294 prevalent cases (15.1/10,000 inhabitants). Most of them had at least one glycated hemoglobin test in the year. More than 15 % had co-existing autoimmune comorbidities.

Conclusions

The incidence rate of pediatric T1DM in Friuli Venezia Giulia has increased in the last years, and the disease is a relevant public health issue in the region.

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Author information

Authors and Affiliations

  1. Servizio Epidemiologico, Direzione centrale salute, integrazione sociosanitaria, politiche sociali e famiglia, Regione autonoma Friuli Venezia Giulia, Via Pozzuolo 330, 33100, Udine, Italy

    Francesca Valent & Loris Zanier

  2. Azienda per l’Assistenza Sanitaria N. 1 “Triestina”, 34148, Trieste, Italy

    Riccardo Candido

  3. IRCCS materno infantile “Burlo Garofolo”, 34137, Trieste, Italy

    Elena Faleschini

  4. Azienda Ospedaliero Universitaria di Udine, 33100, Udine, Italy

    Laura Tonutti & Manuela Zanatta

  5. Azienda per l’Assistenza Sanitaria N. 2 “Bassa Friulana-Isontina”, 34170, Gorizia, Italy

    Carla Tortul

  6. Azienda per l’Assistenza Sanitaria N. 5 “Friuli Occidentale”, 33170, Pordenone, Italy

    Giorgio Zanette

Authors
  1. Francesca Valent
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  2. Riccardo Candido
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  3. Elena Faleschini
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  4. Laura Tonutti
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  5. Carla Tortul
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  6. Manuela Zanatta
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  7. Giorgio Zanette
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  8. Loris Zanier
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Corresponding author

Correspondence to Francesca Valent.

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Ethical standard

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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Valent, F., Candido, R., Faleschini, E. et al. The incidence rate and prevalence of pediatric type 1 diabetes mellitus (age 0–18) in the Italian region Friuli Venezia Giulia: population-based estimates through the analysis of health administrative databases. Acta Diabetol 53, 629–635 (2016). https://doi.org/10.1007/s00592-016-0854-0

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