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Effects of diet and exercise on weight-related outcomes for breast cancer survivors and their adult daughters: an analysis of the DAMES trial

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Abstract

Purpose

Few trials have aimed to promote diet and exercise behaviors in both cancer survivors and their family members and examine their associations with weight-related outcomes. We conducted a secondary analysis to examine associations between change in diet and exercise behaviors and weight-related outcomes for overweight breast cancer survivors and their overweight adult daughters in the Daughters And MothErS Against Breast Cancer (DAMES) randomized trial.

Methods

The DAMES trial assessed the impact of two iteratively tailored, mailed print diet and exercise interventions against standard brochures over a 12-month period. This analysis examined change in diet and exercise behaviors and weight-related variables from baseline to post-intervention for the 50 breast cancer survivors and their adult daughters randomized to the intervention arms. To reduce the potential for type II error in this pilot, p values <0.10 were considered statistically significant.

Results

For mothers, change in diet quality was uniquely related to change in BMI (β = −0.12, p = 0.082), weight (β = −0.12, p = 0.060), and waist circumference (β = −0.38, p = 0.001), whereas change in caloric intake was related to waist circumference (β = 0.21, p = 0.002). For daughters, change in caloric intake was related to change in waist circumference (β = 0.12, p = 0.055). However, change in diet quality was not associated with weight-related outcomes in daughters. Additionally, change in exercise was not associated with weight-related outcomes in mothers or daughters.

Conclusions

Findings support mail-based and other tailored interventions for weight loss in this population, with an emphasis on diet quality for breast cancer survivors and caloric intake for their adult daughters.

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Acknowledgements

Research reported in this publication was supported by the National Cancer Institute under Award Number R21CA122143 (to Dr. Demark-Wahnefried). Ms. Tometich’s work was supported by R25CA117865, and Dr. Mosher’s work was supported by K07CA168883 and K05CA175048 from the National Cancer Institute. Its content is solely the responsibility of the authors and does not necessarily represent the official views of the National Cancer Institute.

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Authors and Affiliations

  1. Department of Psychology, Indiana University-Purdue University Indianapolis, 402 North Blackford Street, LD 133, Indianapolis, IN, 46202, USA

    Danielle B. Tometich, Catherine E. Mosher & Joseph G. Winger

  2. Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA

    Hoda J. Badr

  3. Duke University School of Medicine, DUMC 2713, Durham, NC, 27710, USA

    Denise C. Snyder

  4. Duke Center for the Study of Aging and Human Development, Duke University Medical Center, Duke Box 3003, Durham, NC, 27710, USA

    Richard J. Sloane

  5. Duke University School of Nursing, Durham, NC, USA

    Richard J. Sloane & Wendy Demark-Wahnefried

  6. Department of Nutrition Sciences, University of Alabama at Birmingham, 1824 6th Ave. S., WTI 102M, Birmingham, AL, 35294, USA

    Wendy Demark-Wahnefried

Authors
  1. Danielle B. Tometich
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  2. Catherine E. Mosher
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  7. Wendy Demark-Wahnefried
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Correspondence to Danielle B. Tometich.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Tometich, D.B., Mosher, C.E., Winger, J.G. et al. Effects of diet and exercise on weight-related outcomes for breast cancer survivors and their adult daughters: an analysis of the DAMES trial. Support Care Cancer 25, 2559–2568 (2017). https://doi.org/10.1007/s00520-017-3665-0

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