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First mid-term results after cancellous allograft vitalized with autologous bone marrow for infected femoral non-union

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Summary

Background

Surgical treatment of infected femoral non-union is challenging. Only few reports exist including autologous bone grafting (ABG) from the iliac crest promoting union. Vitalized allogeneic bone grafting (VABG) is an alternative promoting osseous healing and reconstructing bone defects. VABG contains allogeneic cancellous bone, impregnated with autologous bone marrow puncture harvested from the iliac crest. Yet, no systematic trial exists summarizing the results of septic femoral non-union using VABG analyzing the infection eradication rate, rate of osseous integration with union, and osseous remodeling.

Methods

In this prospective non-randomized cohort study, 18 patients treated by nailing or plating for femur fractures that subsequently developed a septic non-union were included. The surgical intervention included a standardized protocol by eradicating infection first, followed by implantation VABG to promote osseous union. Main outcome measurements were radiographic union and clinical parameters.

Results

Mean follow-up was 5.9 years (range: 2–8 years). Infection eradication was achieved for all patients, while union was achieved in 15 out of 18 cases (83.3 %). Mean time for union took 16.9 weeks (range: 12–24). Radiographic analysis proved osseous remodeling and full integration of VABG within 12 months for 15 patients. No infection recurrence occurred at final follow-up.

Conclusions

VABG demonstrated a high union rate without donor site morbidity as the main advantage over ABG. Sufficient osseous integration within 3 months and remodeling within 12 months are promising aspects, as no late fatigue fractures occurred. However, further trials are necessary due to the limitations of this study.

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Authors and Affiliations

  1. Berufsgenossenschaftliche Unfallklinik Tübingen, Eberhard Karls Universität Tübingen, Schnarrenbergstr. 95, 72076, Tübingen, Germany

    Steffen Schröter MD,  Atesch Ateschrang MD,  Ingo Flesch,  Ulrich Stöckle &  Thomas Freude MD

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  1. Steffen Schröter MD
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  2. Atesch Ateschrang MD
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  3. Ingo Flesch
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  4. Ulrich Stöckle
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  5. Thomas Freude MD
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Correspondence to Atesch Ateschrang MD.

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Schröter, S., Ateschrang, A., Flesch, I. et al. First mid-term results after cancellous allograft vitalized with autologous bone marrow for infected femoral non-union. Wien Klin Wochenschr 128, 827–836 (2016). https://doi.org/10.1007/s00508-015-0797-4

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  • DOI: https://doi.org/10.1007/s00508-015-0797-4

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