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Thriving within the host: Candida spp. interactions with phagocytic cells

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Abstract

Certain Candida spp. (e.g. C. albicans, C. tropicalis, C. parapsilosis and C. glabrata) are not only well-adapted fungal commensals of humans, but are also able to cause superficial mucosal infections or even systemic disease. Professional phagocytes (neutrophils, macrophages and dendritic cells) constitute the first line of defence against Candida spp. Here, we review the interactions of phagocytes with pathogenic Candida spp., focusing on macrophages and neutrophils. We discuss the mechanisms involved in recognition, uptake and killing of these fungi. We go on to analyse the cellular responses of these yeasts towards phagocyte-imposed stresses, including metabolic flexibility, robust oxidative stress response and ability to cope with nitrosative stress. Finally, we address strategies that allow these opportunistic pathogens to thrive within the host, evading and escaping from the phagocyte attack.

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Acknowledgments

We are indebted to the European Commission for funding the FINSysB Marie Curie Initial Training Network (PITN-GA-2008-214004) and the Deutsche Forschungsgemeinschaft (DFG Hu 528/15-1). We thank Franziska Gerwien for providing microphotographs for Fig. 1 and Duncan Wilson for critical reading of the manuscript. We thank all members of the Department of Microbial Pathogenicity Mechanisms for helpful discussions.

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  1. Department of Microbial Pathogenicity Mechanisms, Leibniz Institute for Natural Product Research and Infection Biology, Hans-Knoell-Institute, Beutenbergstrasse 11a, 07745, Jena, Germany

    Pedro Miramón, Lydia Kasper & Bernhard Hube

  2. Center for Sepsis Control and Care, Universitätsklinikum Jena, Jena, Germany

    Bernhard Hube

  3. Friedrich Schiller University, Jena, Germany

    Bernhard Hube

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  1. Pedro Miramón
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  2. Lydia Kasper
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Correspondence to Bernhard Hube.

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Miramón, P., Kasper, L. & Hube, B. Thriving within the host: Candida spp. interactions with phagocytic cells. Med Microbiol Immunol 202, 183–195 (2013). https://doi.org/10.1007/s00430-013-0288-z

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