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Postnatal exposure to voluntary exercise but not the antioxidant catechin protects the vasculature after a switch to an atherogenic environment in middle-age mice

  • Integrative Physiology
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Abstract

We aimed to evaluate the lasting functional imprinting of exercise (EX) and catechin (CAT) on the vascular function of middle-age mice switched to a proatherogenic environment. C57BL/6J mice (n = 10–15 in each group) fed a regular diet (RD) were exposed from the age of 1 to 9 months either to EX (voluntary running; 2.7 ± 0.2 km/day), to the polyphenol CAT (30 mg/kg/day in drinking water), or to physical inactivity (PI). At 9 months of age, EX and CAT were stopped and mice either remained on the RD or were fed a Western diet (WD) for an additional 3 months. At 12 months of age, mice from all groups fed a WD had similar body mass, systolic blood pressure, and plasma total cholesterol, glucose, insulin, and isoprostane. Compared to the RD, the WD induced an indomethacin-sensitive aortic endothelium-dependent and independent dysfunction in PI mice (p < 0.05) that was prevented by both EX and CAT; this benefit was associated with a higher (p < 0.05) non-nitric oxide/non-prostacyclin endothelium-dependent relaxation. While EX, but not PI or CAT, prevented vascular dysfunction induced by the WD in cerebral arteries, it had no effect in femoral arteries. The profiles of activity of antioxidant enzymes and of proinflammatory gene expression in the aorta suggest a better adaptation of EX > CAT > PI mice to stress. In conclusion, our data suggest that a postnatal exposure to EX, but not to CAT, imprints an adaptive defense capacity in the vasculature against a deleterious change in lifestyle.

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Acknowledgments

The authors would like to thank the staff of the animal facility of the Montreal Heart Institute. This study was supported by the Canadian Institutes for Health Research (E.T. MOP#14496). F. Leblond is supported by a Banting and Best Ph.D. scholarship from the Canadian Institutes for Health Research.

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The experiments comply with the current laws of Canada in which they were performed.

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The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Pharmacology, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada

    Francois Leblond, Albert Nguyen, Virginie Bolduc, Carol Yu & Eric Thorin

  2. Department of Social and Preventive Medicine, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada

    Jean Lambert

  3. Department of Surgery, Faculty of Medicine, Université de Montréal, Montreal, Quebec, Canada

    Eric Thorin

  4. Research Centre, Montreal Heart Institute, 5000 Rue Bélanger, Montreal, Quebec, Canada, H1T 1C8

    Francois Leblond, Albert Nguyen, Virginie Bolduc, Carol Yu, Natacha Duquette & Eric Thorin

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  1. Francois Leblond
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Correspondence to Eric Thorin.

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Leblond, F., Nguyen, A., Bolduc, V. et al. Postnatal exposure to voluntary exercise but not the antioxidant catechin protects the vasculature after a switch to an atherogenic environment in middle-age mice. Pflugers Arch - Eur J Physiol 465, 197–208 (2013). https://doi.org/10.1007/s00424-012-1206-8

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  • DOI: https://doi.org/10.1007/s00424-012-1206-8

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