Journal of Neurology

, Volume 252, Issue 2, pp 208–211

High frequency stimulation of the subthalamic nucleus is efficacious in Parkin disease

  • Luigi M. A. Romito
  • Maria F. Contarino
  • Daniele Ghezzi
  • Angelo Franzini
  • Barbara Garavaglia
  • Alberto Albanese
ORIGINAL COMMUNICATION

DOI: 10.1007/s00415-005-0638-x

Cite this article as:
Romito, L.M.A., Contarino, M.F., Ghezzi, D. et al. J Neurol (2005) 252: 208. doi:10.1007/s00415-005-0638-x

Abstract

High frequency stimulation (HFS) of the subthalamic nucleus (STN) is an efficacious symptomatic treatment for Parkinson’s disease. We have analysed the genetic status of a series of consecutive parkinsonian patients implanted for STN HFS and compared the outcome of five carrying mutations in the parkin gene with that of the non-parkin group. All patients obtained sustained control of PD symptoms and achieved functional improvement; in the parkin group the UPDRS motor score improved by 56.4%, the levodopa equivalent daily dosage was reduced by 75.5%. Postoperative medications were reduced more in parkin than in non-parkin patients. We confirm that the current inclusion criteria for STN HFS do not exclude patients carrying mutations in the parkin gene; their clinical outcome is comparable to that of the non-parkin group.

Key words

neurostimulationdeep brain stimulationParkinson’s diseasesurgerysubthalamic stimulationPARK2parkin disease

Abbreviations

HFS

High-frequency stimulation

PD

Parkinson’s disease

LEDD

Levodopa equivalent daily dose

STN

Subthalamic nucleus

UPDRS

Unified Parkinson’s disease rating scale

Copyright information

© Steinkopff Verlag 2005

Authors and Affiliations

  • Luigi M. A. Romito
    • 1
    • 2
  • Maria F. Contarino
    • 2
  • Daniele Ghezzi
    • 1
  • Angelo Franzini
    • 1
  • Barbara Garavaglia
    • 1
  • Alberto Albanese
    • 1
    • 2
  1. 1.Istituto Nazionale Neurologico Carlo BestaMilanoItaly
  2. 2.Università Cattolica del Sacro CuoreMilanoItaly