Skip to main content

Advertisement

SpringerLink
Log in

Survival analysis of laryngeal carcinoma without laryngectomy, radiotherapy, or chemotherapy

  • Head and Neck
  • Published:
European Archives of Oto-Rhino-Laryngology Aims and scope Submit manuscript

Abstract

This study aimed at investigating the survival rate and prognostic factors of laryngeal carcinoma patients in the absence of the use of laryngectomy, radiotherapy, and chemotherapy. A total of 167 cases of laryngeal carcinoma without the use of laryngectomy, radiotherapy, or chemotherapy were analyzed retrospectively. Surveyed items included age, smoking history, tumor family history, tuberculosis history, primary site, pathological grade, T-stage, N-stage, clinical stage, and whether tracheotomy had been performed. Survival rates were calculated using the Kaplan–Meier method. For univariate analysis, comparison among/between groups was performed using the log-rank test. Multivariate analysis was carried out using the Cox proportional hazard model. Overall median survival time was 16 ± 1.44 months, and overall 1- and 2-year survival rates were 56.4 and 26.5%, respectively. No patient survived over 5 years in cases diagnosed for more than 5 years (except for cases that were lost). The median survival time of clinical stage 0/I/II was 28 ± 3.81 months, and 1- and 2-year survival rates were 79.3 and 59.3%, respectively; the median survival time of III/IV clinical stages was 11 ± 1.32 months, and 1- and 2-year survival rates were 45.5 and 10.6%, respectively. Univariate analysis showed that primary site, pathological grade, T-stage, N-stage, and clinical stage were significant prognostic factors for the survival of the patients (P < 0.05). Whether tracheotomy had been performed was not significant for affecting survival rates. Multivariate analysis showed survival rates were statistically correlated with T-stage and N-stage (P < 0.05). The development of laryngeal carcinoma course was faster, without treatment to the tumor itself, even if palliative surgery such as tracheostomy would not improve the survival rate. In laryngeal carcinoma patients with no surgery, radiotherapy or chemotherapy, the factors affecting the survival rates include primary site, pathological grade, T-stage, N-stage, and clinical stage, and of them, T-stage and N-stage are the independent prognostic factors.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6

Similar content being viewed by others

References

  1. Danic D, Maruĭć M, Uzarević B et al (2000) Prognostic factors in squamous cell carcinoma of the larynx. ORL J Otorhinolaryngol Relat Spec 62(3):143–148

    Article  PubMed  CAS  Google Scholar 

  2. Nguyen-Tan PF, Le QT, Quivey JM et al (2001) Treatment results and prognostic factors of advanced T3–4 laryngeal carcinoma: the University of California, San Francisco (UCSF) and Stanford University Hospital (SUH) experience. Int J Radiat Oncol Biol Phys 50(5):1172–1180

    Article  PubMed  CAS  Google Scholar 

  3. Papadas TA, Alexopoulos EC, Mallis A et al (2010) Survival after laryngectomy: a review of 133 patients with laryngeal carcinoma. Eur Arch Otorhinolaryngol 267(7):1095–1101

    Article  PubMed  Google Scholar 

  4. Rudolph E, Dyckhoff G, Becher H et al (2011) Effects of tumour stage, comorbidity and therapy on survival of laryngeal cancer patients: a systematic review and a meta-analysis. Eur Arch Otorhinolaryngol 268(2):165–179

    Article  PubMed  Google Scholar 

  5. Jing J, Zhong Xing L, Li G et al (2002) Analysis of prognostic factors for T1N0M0 glottic cancer treated with definitive radiotherapy alone: experience of the cancer hospital of Peking Union Medical College and the Chinese Academy of Medical Sciences. Int J Radiat Oncol Biol Phys 54(2):471–478

    Article  Google Scholar 

  6. Haugen H, Johansson KA, Mercke C (2002) Hyperfractionated-accelerated or conventionally fractionated radiotherapy for early glottic cancer. Int J Radiat Oncol Biol Phys 52(1):109–119

    Article  PubMed  Google Scholar 

  7. Back G, Sood S (2005) The management of early laryngeal cancer: options for patients and therapists. Curr Opin Otolaryngol Head Neck Surg 13(2):85–91

    Article  PubMed  Google Scholar 

  8. Spector GJ, Sessions DG, Lenox J et al (2004) Management of stage IV glottic carcinoma: therapeutic outcomes. Laryngoscope 114(8):1438–1446

    Article  PubMed  Google Scholar 

  9. Holsinger FC, Lin HY, Bassot V et al (2009) Platin-based exclusive chemotherapy for selected patients with squamous cell carcinoma of the larynx and pharynx. Cancer 115(17):3909–3918

    Article  PubMed  CAS  Google Scholar 

  10. Chijiwa H, Sato K, Umeno H et al (2009) Histopathological study of correlation between laryngeal space invasion and lymph node metastasis in glottic carcinoma. J Laryngol Otol Suppl 123(31):48–51

    Article  Google Scholar 

  11. Forastiere AA (2010) Larynx preservation and survival trends: should there be concern? Head Neck 32(1):14–17

    PubMed  Google Scholar 

  12. Hoffman HT, Porter K, Karnell LH et al (2006) Laryngeal cancer in the United States: changes in demographics, patterns of care, and survival. Laryngoscope 116(111):11–13

    Article  Google Scholar 

  13. Olsen KD (2010) Reexamining the treatment of advanced laryngeal cancer. Head Neck 32(1):1–7

    PubMed  Google Scholar 

Download references

Conflict of interest

There is no financial relationship with the organization that sponsored the research.

Author information

Authors and Affiliations

  1. Department of Otolaryngology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China

    Qiong Yu, Suling Hong & Guohua Hu

  2. Department of Otorhinolaryngology, Southwest Hospital, Third Military Medical University, Chongqing, 400038, China

    Xueyuan Zhang

  3. Department of Otorhinolaryngology, Daping Hospital, Third Military Medical University, Chongqing, 400042, China

    Changyou Ji

  4. Department of Otorhinolaryngology Head and Neck Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China

    Hua Yang

  5. Department of Otorhinolaryngology Head and Neck Surgery, Chongqing the Third Hospital Brief, Chongqing, 400014, China

    Minghua Gao

Authors
  1. Qiong Yu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Xueyuan Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Changyou Ji
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Hua Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Minghua Gao
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Suling Hong
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Guohua Hu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Guohua Hu.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yu, Q., Zhang, X., Ji, C. et al. Survival analysis of laryngeal carcinoma without laryngectomy, radiotherapy, or chemotherapy. Eur Arch Otorhinolaryngol 269, 2103–2109 (2012). https://doi.org/10.1007/s00405-011-1873-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00405-011-1873-7

Keywords

Search

Navigation