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Cytokeratin expression pattern in congenital and acquired pediatric cholesteatoma

  • Otology
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Abstract

Pediatric cholesteatoma can be classified as congenital or acquired based on clinical criteria. We studied the expression patterns of five distinctive cytokeratins in both types of cholesteatoma in order to improve understanding of their pathogenesis and origin. A comparable expression pattern for CK10, CK14, CK18, CK19 and 34βE12 antigens was found in the matrix of congenital and acquired pediatric cholesteatoma. Our results demonstrate that congenital and acquired pediatric cholesteatoma exhibit an identical cytokeratin distribution pattern, suggesting that they share a common origin. Therefore, it seems possible that a portion of the so-called “acquired” cholesteatoma may actually originate from advanced congenital cholesteatoma with secondary destruction of the tympanic membrane in the pediatric patient population.

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Authors and Affiliations

  1. Department of Otorhinolaryngology and Head and Neck Surgery, St. Elisabeth Hospital, University of Bochum, Bleichstrasse 15, 44787, Bochum, Germany

    Ewa Olszewska, Jürgen Lautermann, Matthias Schwaab, Stefan Dazert, Henning Hildmann & Holger Sudhoff

  2. Department of Otorhinolaryngology-Head and Neck Surgery, School of Medicine, Kirikkale University, Kirikkale, Turkey

    Can Koc

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  1. Ewa Olszewska
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  2. Jürgen Lautermann
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Correspondence to Holger Sudhoff.

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Olszewska, E., Lautermann, J., Koc, C. et al. Cytokeratin expression pattern in congenital and acquired pediatric cholesteatoma. Eur Arch Otorhinolaryngol 262, 731–736 (2005). https://doi.org/10.1007/s00405-004-0875-0

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  • DOI: https://doi.org/10.1007/s00405-004-0875-0

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