Abstract
Cholesteatoma is a benign, expanding, and destructive epithelial lesion of the temporal bone. The pathogenesis of cholesteatoma postulates that it results from the defective healing process, in which the normal maturation end-stage of the wound-healing process will not be achieved (non-stop wound-healing process); also it relies on the immunological status of the bottom of the ear canal skin.
This chapter emphasizes the recent advances in its molecular biology, which is behind its growth and progress to invade noble contiguous structures leading to hearing loss and cranial complications. Imaging modalities’ developments allowed for high sensitivity and specificity in identifying not only the presence and extensions of this pathology but also help in its recent classification, orient its surgical management, detect its recurrences, and help the practitioners in the decision making during a long-term follow-up. A Review of its clinical manifestations, surgical strategies, and approaches are presented along with the input of endoscopy to avoid residuals.
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Mansour, S., Al Shawabkeh, M.A., Nicolas, K., Haidar, H. (2021). Cholesteatoma. In: Al-Qahtani, A., Haidar, H., Larem, A. (eds) Textbook of Clinical Otolaryngology. Springer, Cham. https://doi.org/10.1007/978-3-030-54088-3_6
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DOI: https://doi.org/10.1007/978-3-030-54088-3_6
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