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Recent trends of cervical cancer and Cervical Intraepithelial Neoplasia 3 (CIN3) in Israel

  • Gynecologic Oncology
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

This study describes time trends of cervical cancer and Cervical Intraepithelial Neoplasia 3 (CIN3) in Israel in the years 1986–2010 and characterizes these patients by demographics.

Methods

A retrospective survey based on cervical cancer and CIN3 data documented in the computerized system of the second largest Health Maintenance Organizations (HMO) in Israel, “Maccabi Healthcare Services” (MHS) between 1986 and 2010.

Results

737 cervical cancer patients and 3,459 patients of CIN3 were reported between 1986 and 2010. The mean age of women with cervical cancer was significantly higher (mean 49.1 years) than that of CIN3 patients (mean 36.3 years) (p-value < 0.0001). The annual age-adjusted incidence rate of cervical cancer increased significantly from 1.6 per 100,000 in 1986 to 3.7 per 100,000 in 2010 (p for trend = 0.0001) and for CIN3, from 3.9 per 100,000 in 1986 to 40.4 per 100,000 in 2010 (p for trend = 0.0001). For cervical cancer, using the Joinpoint software we demonstrated an increase in the age-adjusted incidence rate between 1986 and 2003 and since then, a decrease was observed. Cervical cancer and CIN3 were mostly common in the Tel Aviv District.

Conclusions

Although quite low to begin with, the incidence rates of cervical cancer and CIN3 in Israel may be further lowered by implementing an organized screening program and introduction of the HPV vaccine into the national immunization program.

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Acknowledgments

We would like to give our sincerest thanks to the following people: Lia Supino Rosin, Michael Schvimer and Judith Sandbank from the Institute of Pathology, Central Lab, Maccabi Healthcare Services, Rehovot, Israel, for their laboratory work.

Conflict of interest

The authors declare that they have no conflict of interest.

Author information

Authors and Affiliations

  1. Department of Epidemiology and Preventive Medicine, Sackler Faculty of Medicine, School of Public Health, Tel Aviv University, Tel-Aviv, Israel

    Ravit Bassal & Dani Cohen

  2. Israel Center for Disease Control, Ministry of Health, Sheba Medical Center, Ramat-Gan, Israel

    Ravit Bassal, Zalman Kaufman & Lital Keinan-Boker

  3. Women Health Center, Maccabi Healthcare Services, Tel-Aviv, Israel

    Eduardo Schejter & Rachel Bachar

  4. Institute of Pathology, Maccabi Healthcare Services, Rehovot, Israel

    Hagit Shapira

  5. Stanley Steyer Institute for Epidemiology and Research, Tel Aviv University, Tel-Aviv, Israel

    Dani Cohen

  6. School of Public Health, University of Haifa, Haifa, Israel

    Lital Keinan-Boker

Authors
  1. Ravit Bassal
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  2. Eduardo Schejter
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Corresponding author

Correspondence to Ravit Bassal.

Additional information

This work was performed in partial fulfillment of the requirements for a Ph.D. degree of Ravit Bassal, Sackler Faculty of Medicine, Tel Aviv University, Israel.

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Bassal, R., Schejter, E., Bachar, R. et al. Recent trends of cervical cancer and Cervical Intraepithelial Neoplasia 3 (CIN3) in Israel. Arch Gynecol Obstet 292, 405–413 (2015). https://doi.org/10.1007/s00404-015-3655-8

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  • DOI: https://doi.org/10.1007/s00404-015-3655-8

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