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Brain invasion in otherwise benign meningiomas does not predict tumor recurrence

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Authors and Affiliations

  1. Department of Neurosurgery, Goethe University Frankfurt, Frankfurt am Main, Germany

    Peter Baumgarten, Florian Gessler, Christian Senft, Lioba Imoehl & Volker Seifert

  2. Department of Neuropathology, Eberhard-Karls University Tübingen, Tübingen, Germany

    Jens Schittenhelm

  3. Center for CNS tumors, Comprehensive Cancer Center Tübingen-Stuttgart, University Hospital Tübingen, Eberhard Karls University Tübingen, Tübingen, Germany

    Jens Schittenhelm & Marco Skardelly

  4. Department of Neurosurgery, Eberhard-Karls University Tübingen, Tübingen, Germany

    Marco Skardelly

  5. Edinger Institute, Institute of Neurology, Goethe University Frankfurt, 60528, Frankfurt am Main, Germany

    Dominique S. Tews, Maika Dunst, Karl H. Plate, Michel Mittelbronn & Patrick N. Harter

  6. German Cancer Consortium (DKTK), Partner Site Frankfurt/Mainz, Frankfurt, Germany

    Karl H. Plate, Joachim P. Steinbach, Michel Mittelbronn & Patrick N. Harter

  7. German Cancer Research Center (DKFZ), Heidelberg, Germany

    Karl H. Plate, Joachim P. Steinbach, Michel Mittelbronn & Patrick N. Harter

  8. Department of Neuroradiology, Goethe University Frankfurt, Frankfurt am Main, Germany

    Marlies Wagner

  9. Dr. Senckenberg Institute of Neurooncology, Goethe University Frankfurt, Frankfurt am Main, Germany

    Joachim P. Steinbach

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  1. Peter Baumgarten
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  2. Florian Gessler
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  3. Jens Schittenhelm
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  5. Dominique S. Tews
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  8. Lioba Imoehl
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  11. Joachim P. Steinbach
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  12. Volker Seifert
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  13. Michel Mittelbronn
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  14. Patrick N. Harter
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Corresponding author

Correspondence to Patrick N. Harter.

Electronic supplementary material

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401_2016_1598_MOESM1_ESM.docx

Supplementary Table 1: Clinical and pathological information on the investigated cohort. The study protocol was endorsed by the local ethical committee (G-No. 4/09 SNO-09-2015) (DOCX 15 kb)

401_2016_1598_MOESM2_ESM.tif

Supplementary Figure 1: Univariate Kaplan–Meier overall (a) and progression-free (b-d) survival analysis of WHO grade II meningiomas in different meningioma subtypes (brain invasive otherwise benign, distinct histological subtype, atypical histology/increased mitoses). (b) Analysis of the cohort only of the cases where CNS tissue was present on the slices. (c, d) Stratification of the cohort in short and long follow-up after median split. Median follow-up of the whole cohort was 22 months (TIFF 1192 kb)

401_2016_1598_MOESM3_ESM.tif

Supplementary Figure 2: Analysis of number of tissue blocks and the assessability of brain invasion in the investigated cohort (a-c). Results of ANOVA are depicted (a, b). (c) Results of non-parametric paired comparisons using Dunn’s method. (d-k) Overview of different brain invasion patterns. All shown tumors are brain invasive otherwise benign meningiomas. (d) Fingerlike-projections (arrowheads) of tumor tissue into CNS tissue. (e) Irregular tumor protrusions into CNS tissue and a focally disrupted leptomeningeal layer (arrowhead). (f) Entrapped piece of CNS tissue (asterisk) invaded by tumor projections. GFAP staining of same tissue block (g) shows tumor protrusions invading CNS tissue. (h) Part of cerebellum with a small collection of meningioma tumor cells in a cluster (asterisk), deeper section of the same tissue block and GFAP staining (i) revealed unequivocal tumor invasion. (j) GFAP staining of a meningioma. Arrowheads show little pieces of CNS tissue which are invaded by a larger tumor protrusion. (k) Larger protrusion invading CNS tissue with a large reactive astrocyte (arrowhead) (TIFF 44239 kb)

401_2016_1598_MOESM4_ESM.tif

Supplementary Figure 3: Univariate Kaplan–Meier progression-free survival analysis in the cohort of all grade II meningiomas (column a) and the subcohort of meningiomas with atypical histology/increased mitoses (column b). Extent of resection is reflected by the Simpson score. STR (subtotal resection), GTR (gross total resection) (TIFF 1142 kb)

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Baumgarten, P., Gessler, F., Schittenhelm, J. et al. Brain invasion in otherwise benign meningiomas does not predict tumor recurrence. Acta Neuropathol 132, 479–481 (2016). https://doi.org/10.1007/s00401-016-1598-1

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