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Subgroup-specific localization of human medulloblastoma based on pre-operative MRI

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References

  1. Gibson P, Tong Y, Robinson G et al (2010) Subtypes of medulloblastoma have distinct developmental origins. Nature 468(7327):1095–1099. doi:10.1038/nature09587

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  2. Grammel D, Warmuth-Metz M, von Bueren AO et al (2012) Sonic hedgehog-associated medulloblastoma arising from the cochlear nuclei of the brainstem. Acta Neuropathol 123(4):601–614. doi:10.1007/s00401-012-0961-0

    Article  CAS  PubMed  Google Scholar 

  3. Kool M, Jones D, Jäger N et al (2014) Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened-inhibition. Cancer Cell 25(3):393–405. doi:10.1016/j.ccr.2014.02.004

    Google Scholar 

  4. Northcott PA, Hielscher T, Dubuc A et al (2011) Pediatric and adult sonic hedgehog medulloblastomas are clinically and molecularly distinct. Acta Neuropathol 122(2):231–240. doi:10.1007/s00401-011-0846-7

    Article  PubMed  Google Scholar 

  5. Schüller U, Heine VM, Mao J et al (2008) Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form SHH-induced medulloblastoma. Cancer Cell 14(2):123–134. doi:10.1016/j.ccr.2008.07.005

    Article  PubMed Central  PubMed  Google Scholar 

  6. Taylor MD, Northcott PA, Korshunov A et al (2012) Molecular subgroups of medulloblastoma: the current consensus. Acta Neuropathol 123(4):465–472. doi:10.1007/s00401-011-0922-z

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  7. Teo WY, Shen J, Su JM et al (2013) Implications of tumor location on subtypes of medulloblastoma. Pediatr Blood Cancer 60(9):1408–1410. doi:10.1002/pbc.24511

    Article  PubMed  Google Scholar 

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Acknowledgments

This work was supported by grants from the Deutsche Krebshilfe (Max-Eder junior research program), the Wilhelm Sander Foundation and the Else-Kröner-Fresenius Foundation (all to U.S.). The Department of Neuroradiology at the University of Würzburg, the HIT Reference Center for Neuropathology in Bonn and the HIT trial office in Hamburg were supported by the German Children’s Cancer Foundation (Deutsche Kinderkrebsstiftung), the last also by the Fördergemeinschaft Kinderkrebszentrum Hamburg e. V..

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Authors and Affiliations

  1. Center for Neuropathology, Ludwig-Maximilians-University, Feodor-Lynen-Strasse 23, 81377, Munich, Germany

    Annika K. Wefers, Julia Pöschl & Ulrich Schüller

  2. Department of Neuroradiology, Julius-Maximilians-University, Würzburg, Germany

    Monika Warmuth-Metz

  3. Division of Pediatric Hematology and Oncology, Georg-August-University, Göttingen, Germany

    André O. von Bueren

  4. Department of Neuropathology, Julius-Maximilians-University, Würzburg, Germany

    Camelia-Maria Monoranu

  5. Department of Neuroradiology, Ludwig-Maximilians-University, Munich, Germany

    Klaus Seelos

  6. Department of Neurosurgery, Ludwig-Maximilians-University, Munich, Germany

    Aurelia Peraud & Jörg-Christian Tonn

  7. Department of Neuropathology, Charité Universitätsmedizin, Berlin, Germany

    Arend Koch

  8. Department of Neuropathology, Friedrich-Wilhelms-University, Bonn, Germany

    Torsten Pietsch

  9. Division of Experimental Neurosurgery, University of Heidelberg, Heidelberg, Germany

    Christel Herold-Mende

  10. Department of Neuropathology, Otto von Guericke University, Magdeburg, Germany

    Christian Mawrin

  11. Emma Children’s Hospital Academic Medical Center, Amsterdam, The Netherlands

    Antoinette Schouten-van Meeteren

  12. Free University Hospital Amsterdam, Amsterdam, The Netherlands

    Dannis van Vuurden

  13. Division of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

    André O. von Bueren, Katja von Hoff & Stefan Rutkowski

  14. Division of Pediatric Neurooncology, German Cancer Research Center, Heidelberg, Germany

    Stefan M. Pfister & Marcel Kool

  15. Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany

    Stefan M. Pfister

Authors
  1. Annika K. Wefers
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  2. Monika Warmuth-Metz
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  3. Julia Pöschl
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  4. André O. von Bueren
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  5. Camelia-Maria Monoranu
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  6. Klaus Seelos
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  7. Aurelia Peraud
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  8. Jörg-Christian Tonn
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  9. Arend Koch
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  10. Torsten Pietsch
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  11. Christel Herold-Mende
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  12. Christian Mawrin
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  13. Antoinette Schouten-van Meeteren
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  14. Dannis van Vuurden
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  15. Katja von Hoff
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  16. Stefan Rutkowski
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  17. Stefan M. Pfister
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  18. Marcel Kool
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  19. Ulrich Schüller
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Corresponding author

Correspondence to Ulrich Schüller.

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Wefers, A.K., Warmuth-Metz, M., Pöschl, J. et al. Subgroup-specific localization of human medulloblastoma based on pre-operative MRI. Acta Neuropathol 127, 931–933 (2014). https://doi.org/10.1007/s00401-014-1271-5

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  • DOI: https://doi.org/10.1007/s00401-014-1271-5

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