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Influence of previous treatments on repeat surgery for recurrent craniopharyngiomas in children

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Abstract

Purpose

Craniopharyngioma is a common pediatric brain tumor, with a high rate of recurrence after primary treatment. This retrospective study investigated the effect of various primary treatments on surgical strategies and outcomes for recurrent craniopharyngiomas.

Methods

The study population comprised 35 children (mean age 8.77 years, range 1–16 years) with recurrent craniopharyngioma re-operated from January 1990 to January 2009. The recurrent craniopharyngiomas were excised whenever possible. For analysis, the patients were divided into four groups according to the primary treatment: radical tumor resection (A), incomplete tumor resection (B), radiotherapy + incomplete tumor resection (C), and Ommaya reservoir placement + incomplete tumor resection (D).

Results

Group B had a significantly shorter recurrence-free interval than groups A, C, or D. Outcomes were significantly different among the four groups. The hypothalamic status scores of groups A (2.38 ± 0.27) and C (2.28 ± 0.42) were significantly higher than that of group B (1.64 ± 0.20). There were no statistical differences between any two other groups.

Conclusions

In children, the primary treatments for craniopharyngioma should be considered when choosing the surgical strategy for recurrence. Radiotherapy before repeated surgery can result in a worse functional outcome and hypothalamic-pituitary function.

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Authors and Affiliations

  1. Department of Neurosurgery, Nan Fang Hospital, Southern Medical University, Guangzhou, Guangdong, China

    Yun Bao, Binghui Qiu, Songtao Qi, Jun Pan, Yuntao Lu & Junxiang Peng

Authors
  1. Yun Bao
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  2. Binghui Qiu
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  3. Songtao Qi
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  4. Jun Pan
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Corresponding author

Correspondence to Songtao Qi.

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Statement of ethics

The Medical Ethics Committee of Nanfang Hospital, Southern Medical University, approved this retrospective study.

Funding

This research was funded by the Guangdong Province Natural Science Funding (No. S2011010003063, S2012020010939), President Foundation of Nanfang Hospital, Southern Medical University (2015C028) and the Key Clinical Specialty Discipline Construction Program.

Conflict of interest

The authors declare that there is no conflict of interest.

Additional information

Binghui Qiu is a co-first author of this article.

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Bao, Y., Qiu, B., Qi, S. et al. Influence of previous treatments on repeat surgery for recurrent craniopharyngiomas in children. Childs Nerv Syst 32, 485–491 (2016). https://doi.org/10.1007/s00381-015-3003-0

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  • DOI: https://doi.org/10.1007/s00381-015-3003-0

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