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A biomimetic bi-leaflet mitral prosthesis with enhanced physiological left ventricular swirl restorative capability

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Abstract

Mechanical heart valve prostheses are often implanted in young patients due to their durability and long-term reliability. However, existing designs are known to induce elevated levels of blood damage and blood platelet activation. As a result, there is a need for patients to undergo chronic anti-coagulation treatment to prevent thrombosis, often resulting in bleeding complications. Furthermore, recent studies have suggested that the implantation of a mechanical prosthetic valve at the mitral position results in a significant alteration of the left ventricular flow field which may contribute to flow turbulence. This study proposes a bi-leaflet mechanical heart valve design (Bio-MHV) that mimics the geometry of a human mitral valve, with the aim of reducing turbulence levels in the left ventricle by replicating physiological flow patterns. An in vitro three-dimensional particle velocimetry imaging experiment was carried out to compare the hemodynamic performance of the Bio-MHV with that of the clinically established ATS valve. The Bio-MHV was found to replicate physiological left ventricular flow patterns and produced lower turbulence levels.

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Acknowledgments

We gratefully acknowledge the support of a grant from Biomedical Engineering Programme, Agency of Science, Technology and Research Singapore for this study. The authors thank Dr. Boyang Su and Dr. Foad Kabinejadian for their contribution and advice.

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Authors and Affiliations

  1. Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore, Block E4, #04-08, 4 Engineering Drive 3, Singapore, 117583, Singapore

    Sean Guo-Dong Tan, Sangho Kim & Hwa Liang Leo

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  1. Sean Guo-Dong Tan
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  2. Sangho Kim
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  3. Hwa Liang Leo
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Correspondence to Hwa Liang Leo.

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Tan, S.GD., Kim, S. & Leo, H.L. A biomimetic bi-leaflet mitral prosthesis with enhanced physiological left ventricular swirl restorative capability. Exp Fluids 57, 110 (2016). https://doi.org/10.1007/s00348-016-2195-8

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