Skip to main content
Log in

Verätzungen und Verbrennungen des Auges

Konservative und chirurgische Optionen einer stadiengerechten Therapie

Chemical and thermal eye burns

Conservatíve and surgical options of a stage-dependent therapy

  • Leitthema
  • Published:
Der Ophthalmologe Aims and scope Submit manuscript

Zusammenfassung

Es werden die Grundlagen der medizinischen Versorgung des dringlichen Notfalls Augenverätzung und -verbrennung besprochen. Das Konzept aller Maßnahmen in der Akutphase dient der Verhinderung oder Begrenzung der Gewebezerstörung. Das weitere therapeutische Vorgehen ist auf die Modulation der Entzündungsreaktion, das Abfangen einer bakteriellen Infektion bzw. möglicher Augendrucksteigerungen und auf die Förderung der Wundheilung ausgerichtet. Aus den dargelegten konservativen und chirurgischen Therapieoptionen ist anhand der Klassifikation des Schweregrades der Verätzung sowie einer sorgfältigen Identifizierung zerstörter Gewebestrukturen ein individuelles Maßnahmenkonzept umzusetzen. Bei schweren und schwersten Augenverätzungen gehört hierzu die umfassende chirurgische Sanierung. Die an der Behandlung der Augenverätzung und -verbrennung beteiligten ambulanten und stationären Einrichtungen benötigen ein einheitliches, wissenschaftlich begründetes Therapieregime. Insbesondere ist die lückenlose Fortführung der Behandlung zur Wiederherstellung der Sehkraft entscheidend.

Abstract

The basic principles of first aid for chemical and thermal burns are discussed. In the acute phase the primary goal of all measurements is the prevention or limitation of tissue destruction. The further therapeutic care is focused on the modulation of the inflammatory response, the prevention of a bacterial infection and secondary glaucoma and the stimulation of wound healing. The individual concept of measures to be taken is recruited from the careful identification of necrotic tissue, the eye burn classification of severity and on the basis of all described medical and surgical therapy options. In the case of severe and very severe ocular burns a comprehensive surgical reconstruction is included. All outpatient departments and eye clinics taking part on the treatment have to ensure a standardized complete and scientifically valid therapy regime to restore vision.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Abb. 1
Abb. 2
Abb. 3
Abb. 4
Abb. 5
Abb. 6

Literatur

  1. Bacskulin J, Bacskulin E (1965) Further experiences with subconjunctival autohemotherapy in fresh and old corrosions. Am J Ophthal 59:674–680

    PubMed  CAS  Google Scholar 

  2. Ban Y, Cooper LJ, Fullwood NJ et al (2003) Comparison of ultrastructure, tight junction-related protein expression and barrier function of human corneal epithelial cells cultivated on amniotic membrane with and without airlifting. Exp Eye Res 76:735–743

    Article  PubMed  CAS  Google Scholar 

  3. Bernauer W et al (2006) Corneal calcification following intensified treatment with sodium hyaluronate artificial tears. Br J Ophthalmol 90:285–288

    Article  PubMed  CAS  Google Scholar 

  4. Bernauer W, Thiel MA, Rentsch KM (2006) Phosphate in ophthalmologischen Präparaten. Ophthalmologe 103:416–417

    Article  PubMed  CAS  Google Scholar 

  5. Böhmer JA, Sellhaus B, Schrage NF (2001) Effects of ascorbic acid on retinal pigment epithelial cells. Curr Eye Res 23:206–214

    Article  PubMed  Google Scholar 

  6. Burns F, Stack M, Gray R et al (1989) Inhibition of purified collagenase from alkaliburned rabbit corneas. Invest Ophthalmol Vis Sci 30:1569–1575

    PubMed  CAS  Google Scholar 

  7. Cejkova J (1997) Histochemical study of leukocyte elastase activity in alkali-burned rabbit cornea. Ophthalmic Res 29:154–160

    Article  PubMed  CAS  Google Scholar 

  8. Cheng KC, Chang CH (2006) Modified gunderson conjunctival flap combined with an oral mucosal graft to treat an intractable corneal lysis after chemical burn: a case report. Kaohsiung J Med Sci 22:247–251

    Article  PubMed  Google Scholar 

  9. Cheung PS, Hosseini K (2009) Anti-Inflammatory activity of Azithromycin as measured by its NF-kB inhibitory activity. ARVO, E-Abstract 839/A425

  10. Dan L, Shi-long Y, Miao-li L et al (2008) Inhibitory effect of oral doxycycline on neovascularization in a rat corneal alkali burn model of angiogenesis. Curr Eye Res 33:653–660

    Article  PubMed  CAS  Google Scholar 

  11. Davis AR, Ali QH, Aclimandos WA, Hunter PA (1997) Topical steroid use in the treatment of ocular alkali burns. Br J Ophthalmol 81:732–734

    Article  PubMed  CAS  Google Scholar 

  12. DFG (2008) MAK-und BAT-Werte-Liste 2008. Mitteilung 44. WILEY-VCH & Co. KGaA, S 1–66, S 148

  13. Dietrich T, Weisbach V, Seitz B et al (2008) Herstellung von Eigenserumaugentropfen zur ambulanten Therapie. Ophthalmologe 11:1036–1042

    Article  Google Scholar 

  14. Dua HS, Azuara-Blanco A (2000) Discussion on amniotic membrane transplantation for acute chemical or thermal burns. Ophthalmology 107:990

    Article  Google Scholar 

  15. Dua HS, Azuara-Blanco A (2000) Autologous limbal transplantation in patients with unilateral corneal stem cell deficiency. Br J Ophthalmol 84:273–278

    Article  PubMed  CAS  Google Scholar 

  16. Dua HS, King AJ, Joseph A (2001) A new classification of ocular surface burns. Br J Ophthalmol 85:1379–1383

    Article  PubMed  CAS  Google Scholar 

  17. Fatima A, Iftekhar G, Sangwan VS, Vemuganti GK (2008) Ocular surface changes in limbal stem cell deficiency caused by chemical injury: a histologic study of excised pannus from recipients of cultured corneal epithelium. Eye 22:1161–1167

    Article  PubMed  CAS  Google Scholar 

  18. Feng Y, Feng Y, Zhu X et al (2004) Alkali burn causes aldehyde dehydrogenase 3A1 (ALDH 3A1) decrease in mouse cornea. Mol Vis 10:845–850

    PubMed  CAS  Google Scholar 

  19. Fish R, Davidson RS (2010) Management of ocular thermal and chemical injuries, including amniotic membrane therapy. Curr Opin Ophthalmol 21:317–321

    PubMed  Google Scholar 

  20. Fournier JH, McLachlan DL (2005) Ocular surface reconstruction using amniotic membrane allograft for severe surface disorders in chemical burns: case report and review of the literature. Int Surg 90:45–47

    PubMed  Google Scholar 

  21. Franzco LWH, Summers PM, Franzca DG et al (2004) Controlled trial of hyperbaric oxygen treatment for alkali corneal burn in the rabbit. Clin Experiment Ophthalmol 32:67–70

    Article  Google Scholar 

  22. Friedenwald J, Hughes W, Hermann H (1944) Acid-base tolerance of the cornea. Arch Ophthalmol 31:279–283

    CAS  Google Scholar 

  23. Geerling G (2007) Eigenserum zur Therapie. Concept Ophthalmologie 04:18–20

    Google Scholar 

  24. Geerling G, Grus F, Seitz B et al (2008) Arzneimittelrechtliche Erlaubnis bei der Herstellung von Serum-Augentropfen. Ophthalmologe 7:632–638

    Article  Google Scholar 

  25. Giessler S, Struck HG, Giessler C (1996) Untersuchungen zur konsensuellen Entzündungsreaktion bei Verätzung des Kaninchenauges. Klin Monatsbl Augenheilkd 208:235–238

    Article  PubMed  CAS  Google Scholar 

  26. Gimeno FL, Lavigne V, Gatto S et al (2007) Advances in corneal stem-cell transplantation in rabbits with severe ocular alkali burns. J Cataract Refract Surg 33:1958–1965

    Article  Google Scholar 

  27. Girard B, Bourcier F, Agdabede I, Laroche L (2002) Activity and epidemiology in an ophthalmological emergency center. F Fr Ophthalmol 25:701–711

    CAS  Google Scholar 

  28. Gomes JA, Santos MS dos, Cunha MC et al (2003) Amniotic membrane transplantation for partial and total limbal stem cell deficiency secondary to chemical burn. Ophthalmology 110:466–473

    Article  PubMed  Google Scholar 

  29. Graupner O, Hausmann H (1970) Die Änderung des pH-Wertes in der Vorderkammer des Kaninchenauges nach Verätzung mit kleinsten Mengen laborüblicher Konzentrationen von Säure und Lauge. Graefes Arch Clin Exp Ophthalmol 180:60

    Article  CAS  Google Scholar 

  30. Green K, Paterson CA, Siddiqui A (1985) Ocular blood flow after experimental alkali burns and prostaglandin administration. Arch Ophthalmol 103:569–571

    PubMed  CAS  Google Scholar 

  31. Guogas IM, Boyer JL (2009) Azithromycin suppresses bacterial lipase expressed by staphylococcus. ARVO, E-Abstract 5943/A549

  32. Hahne M, Reichl S (2010) Simulation von Korneaepithelverletzungen mittels mechanischer und korrosiver Schädigung. Ophthalmologe 107:529–536

    Article  PubMed  CAS  Google Scholar 

  33. He J, Bazan NG, Bazan HEP (2006) Alkali-induced corneal stromal melting prevention by a novel platelet-activating factor receptor antagonist. Arch Ophthalmol 124:70–78

    Article  PubMed  CAS  Google Scholar 

  34. Heckelen A, Hermel M, Kondring B, Schrage NF (2004) Ascorbic acid reversibly inhibits proliferation of retinal pigment epithelial cells. Acta Ophthalmol Scand 82:564–568

    Article  PubMed  CAS  Google Scholar 

  35. Herboth T, Geerling G, Duncker G et al (1998) Konsequente Anwendung des Aachener Therapiekonzeptes nach schwerer Verätzung beider Augen. Klin Monatsbl Augenheilkd 212:166–169

    Article  PubMed  CAS  Google Scholar 

  36. Hermel M, Heckelen A, Kirchhof B, Schrage NF (2001) Inhibitory effect of ascorbic acid on human retinal pigment epithelial cell proliferation compared to cytostatic drugs-influence of histamine. Inflamm Res 50(Suppl 2):93–95

    Google Scholar 

  37. Herminghaus P, Geerling G, Hartwig D et al (2004) Epitheliotrophe Kapazität von Serum- und Plasmaaugentropfen. Ophthalmologe 101:998–1005

    PubMed  CAS  Google Scholar 

  38. Herretes S, Suwan-Apichon O, Pirouzmanesh A et al (2006) Use of topical human amniotic fluid in the treatment of acute ocular alkali injuries in mice. Am J Ophthalmol 142:271–278

    Article  PubMed  Google Scholar 

  39. Ho CK, Yen YL, Chang CH et al (2007) Epidemiologic study on work-related eye injuries in Kaohsiung, Taiwan. Kaohsiung J Med Sci 23:463–469

    Article  PubMed  Google Scholar 

  40. Hojer J, Personne M, Hulten P, Ludwigs U (2002) Topical treatments for hydrofluoric acid burns: a blind controlled experimental study. J Toxicol Clin Toxicol 40:861–866

    Article  PubMed  CAS  Google Scholar 

  41. Hosseini H, Nejabat M, Mehryar M et al (2007) Bevacizumab inhibits corneal neovascularization in an alkali burn induced model of corneal angiogenesis. Clinic Experiment Ophthalmol 35:745–748

    Article  Google Scholar 

  42. Hsu JKW, Johnston WT, Read RW et al (2003) Histopathology of corneal melting associated with diclofenac use after refractive surgery. J Cataract Refract Surg 29:250–256

    Article  PubMed  Google Scholar 

  43. Huang Y, Meek KM, Ho MW et al (2001) Analysis of birefringence during wound healing and remodeling following alkali burns in rabbit cornea. Exp Eye Res 73:521–532

    Article  PubMed  CAS  Google Scholar 

  44. Ivekovic R, Tedeschi-Reiner E, Novak-Laus K et al (2005) Limbal graft and/or amniotic membrane transplantation in the treatment of ocular burns. Ophthalmologica 219:297–302

    Article  PubMed  Google Scholar 

  45. Iwanami H, Ishizaki M, Fukuda Y, Takahashi H (2009) Expression of matrix metalloproteinases (MMP)-12 by myofibroblasts during alkali-burned corneal wound healing. Curr Eye Res 34:207–214

    Article  PubMed  CAS  Google Scholar 

  46. Jang IK, Ahn JI, Shin JS et al (2006) Transplantation of reconstructed corneal layer composed of corneal epithelium and fibroblasts on a lyophilized amniotic membrane to severely alkali-burned cornea. Artif Organs 30:424–431

    Article  PubMed  CAS  Google Scholar 

  47. Jeng BH, Dupps WJ (2009) Autologous serum 50% eyedrops in the treatment of persistent corneal epithelial defects. Cornea 28:1104–1108

    Article  PubMed  Google Scholar 

  48. Jiang A, Li C, Gao Y et al (2006) In vivo and in vitro inhibitory effect of amniotic extraction on neovascularization. Cornea 25:36–40

    Article  Google Scholar 

  49. Joseph A, Dua HS, King AJ (2001) Failure of amniotic membrane transplantation in the treatment of acute ocular burns. Br J Ophthalmol 85:1065–1069

    Article  PubMed  CAS  Google Scholar 

  50. Kasper K, Kremling C, Geerling G (2008) Toxizität neuer Benetzungs- und Konservierungsmittel in vitro. Ophthalmologe 6:557–562

    Article  CAS  Google Scholar 

  51. Katircioglu YA, Budak K, Salvarli S, Duman S (2003) Amniotic membrane transplantation to reconstruct the conjunctival surface in case of chemical burn. Jpn J Ophthalmol 47:519–522

    Article  PubMed  Google Scholar 

  52. Kato T, Saika S, Ohnishi Y (2006) Effects of the matrix metalloproteinase inhibitor GM 6001 on the destruction and alteration of epithelial basement membrane during the healing of post-alkali burn in rabbit cornea. Jpn J Ophthalmol 50:90–95

    Article  PubMed  CAS  Google Scholar 

  53. Kenyon KR, Tseng SC (1989) Limbal autograft transplantation for ocular surface disorders. Ophthalmology 96:709–723

    PubMed  CAS  Google Scholar 

  54. Kheirkhah A, Johnson DA, Paranjpe DR et al (2008) Temporary sutureless amniotic membrane patch for acute alkaline burns. Arch Ophthalmol 126:1059–1066

    Article  PubMed  Google Scholar 

  55. Kobayashi A, Shirao Y, Yoshita T et al (2003) Temporary amniotic membrane patching for acute chemical burns. Eye 17:149–158

    Article  PubMed  CAS  Google Scholar 

  56. Kruse FE, Rohrschneider K, Völcker HE (1999) Multilayer amniotic membrane transplantation for reconstruction of deep corneal ulcers. Ophthalmology 106:1504–1510

    Article  PubMed  CAS  Google Scholar 

  57. Kruse FE, Rohrschneider K, Völcker HE (1999) Transplantation von Amnionmembran zur Rekonstruktion der Hornhautoberfläche. Operatives Vorgehen. Ophthalmologe 96:673–678

    Article  PubMed  CAS  Google Scholar 

  58. Kruse FE, Cursiefen C (2008) Surgery of the cornea: corneal, limbal stem cell and amniotic membrane transplantation. In: Geerling G, Brewitt H (Hrsg) Surgery for the dry eye. Karger, Basel, S 159–170

  59. Kruse FE, Meller D (2001) Die Amnionmembrantransplantation zur Rekonstruktion der Augenoberfläche. Ophthalmologe 98:801–810

    Article  PubMed  CAS  Google Scholar 

  60. Kuckelkorn R, Luft I, Kottek AA et al (1993) Verätzungen und Verbrennungen im Einzugsbereich der RWTH Aachen. Klin Monatsbl Augenheilkd 203:34–42

    Article  PubMed  CAS  Google Scholar 

  61. Kuckelkorn R, Kottek A, Reim M (1994) Intraokulare Komplikationen nach schweren Verätzungen – Häufigkeit und chirurgische Behandlung. Klin Monatsbl Augenheilkd 205:86–92

    Article  PubMed  CAS  Google Scholar 

  62. Kuckelkorn R, Makropoulos W, Kottek A, Reim M (1995) Chemische Verätzungen der Augen: Ursachen, Behandlung und Prävention. Arbeitsmed Sozialmed Umweltmed 30:22–33

    Google Scholar 

  63. Kuckelkorn R, Redbrake C, Kottek A et al (1995) Tenon-Plastik und Frühkeratoplastik bei schwerstverätzten Augen. Ophthalmologe 92:439–444

    PubMed  CAS  Google Scholar 

  64. Kuckelkorn R, Kottek A, Schrage N et al (1995) Langzeitergebnisse mit Tenon-Plastik behandelter schwerstverätzter Augen. Ophthalmologe 92:445–451

    PubMed  CAS  Google Scholar 

  65. Kuckelkorn R, Schrage N, Redbrake C et al. (1996) Autologous transplantation of nasal mucosa after severe chemical and thermal eye burns. Acta Ophthalmol Scand 74:442–448

    Article  PubMed  CAS  Google Scholar 

  66. Kuckelkorn R, Wolf S, Remky A, Redbrake C (1996) Fluoreszenzangiographie des vorderen Augenabschnittes bei schwerstverätzten Augen. Klin Monatsbl Augenheilkd 209:109–113

    Article  PubMed  CAS  Google Scholar 

  67. Kuckelkorn R, Redbrake C, Reim M (1997) Tenonplasty: a new surgical approach for the treatment of severe eye burns. Ophthalmic Surg Lasers 28:105–110

    PubMed  CAS  Google Scholar 

  68. Kuckelkorn R, Schrage N, Redbrake C (2000) Erste-Hilfe-Maßnahmen bei Verätzungen und Verbrennungen der Augen. Dtsch Ärzteblatt 97:B90–B95

    Google Scholar 

  69. Kuckelkorn R, Keller GKI, Redbrake C (2001) Glaukom nach schwersten Verätzungen und Verbrennungen. Ophthalmologe 98:1149–1156

    Article  PubMed  CAS  Google Scholar 

  70. Kuznetsov SL, Nikolaeva LR, Spivak IA et al (2006) Effect of transplantation of cultured human neural stem and progenitor cells on regeneration of the cornea after chemical burn. Cell Technol Biol Med 2:129–132

    Google Scholar 

  71. Lass JH, Mack RJ, Imperia PS et al (1989) An in vitro analysis of aminoglycoside corneal epithelial toxicity. Curr Eye Res 8:299–304

    Article  PubMed  CAS  Google Scholar 

  72. Lee SH, Tseng SC (1997) Amniotic membrane transplantation for persistent epithelial defects with ulceration. Am J Ophthalmol 123:303–312

    PubMed  CAS  Google Scholar 

  73. Lenkiewicz E, Ferencowa A, Szewczykowa E (1992) Subconjunctival autohaemotherapy of ocular burns in our cases. Klin Oczna 94:113–114

    PubMed  CAS  Google Scholar 

  74. Liang L, Li W, Ling S et al (2009) Amniotic membrane extraction solution for ocular chemical burns. Clin Experiment Ophthalmol 37:855–863

    Article  PubMed  Google Scholar 

  75. Liggett P (1989) Ocular trauma in an urban population. Ophthalmology 97:581–584

    Google Scholar 

  76. Lin CP, Boehnke M (2000) Effect of fortified antibiotic solutions on corneal epithelial wound healing. Cornea 19:204–206

    Article  PubMed  CAS  Google Scholar 

  77. Ling S, Qi C, Li W et al (2009) Crucial role of corneal lymphangiogenesis for allograft rejection in alkali-burned cornea bed. Clin Experiment Ophthalmol 37:874–883

    Article  PubMed  Google Scholar 

  78. Liu H, Zhang W, Pan Z, Wu Y (2002) Experimental study on the treatment of corneal melting after alkali burn with GM 6001. Zhonghua Yan Ke Za Zhi 38:539–542

    PubMed  Google Scholar 

  79. Lopez Garcia JS, Rivas L, Garcia Lozano I, Murube J (2006) Analysis of corneal surface evolution after moderate alkaline burns by using impression cytology. Cornea 25:908–913

    Article  Google Scholar 

  80. Lubeck D, Greene J (1988) Corneal injuries. Emerg Med Clin North Am 6:73–94

    PubMed  CAS  Google Scholar 

  81. Ma DH, Kuo MT, Tsai YJ et al (2009) Transplantation of cultivated oral mucosal epithelial cells for severe corneal burn. Eye 23:1442–1450

    Article  PubMed  CAS  Google Scholar 

  82. Mac Ewen C (1989) Eye injuries: a prospective survey of 5671 cases. Br J Ophthalmol 73:888–894

    Article  Google Scholar 

  83. Macdonald ECA, Cauchi PA, Azuara-Blanco A, Foot B (2009) Surveillance of severe chemical corneal injuries in the UK. Br J Ophthalmol 93:1177–1180

    Article  PubMed  CAS  Google Scholar 

  84. Makarov PV, Katayev MG, Cundorova RA et al (2009) Rehabilitation of patients with burn injury to the eye. Vestn Oftalmol 125:52–57

    PubMed  CAS  Google Scholar 

  85. Malhotra R, Sheikh I, Dheansa B (2009) The management of eyelid burns. Surv Ophthalmol 54:356–371

    Article  PubMed  Google Scholar 

  86. Marquez De Aracena Del Cid R, Montero De Espinosa Escoriaza I (2009) Subconjunctival application of regenerative factor-rich plasma for the treatment of ocular alkali burns. Eur J Ophthalmol 19:909–915

    Google Scholar 

  87. Maskati QB, Maskati BT (1987) Management of chemical injuries of the eye. Indian J Ophthalmol 35:396–400

    PubMed  CAS  Google Scholar 

  88. Meller D, Pires RT, Mack RJ et al (2000) Amniotic membrane transplantation for acute chemical or thermal burns. Ophthalmology 107:980–989

    Article  PubMed  CAS  Google Scholar 

  89. Meller D, Pauklin M, Westekemper H, Steuhl KP (2010) Autologe Transplantation von kultiviertem Linsenepithel 107:1133–1138

    Google Scholar 

  90. Meller D, Pauklin M, Thomasen H et al (2011) Amnionmembrantransplantation am menschlichen Auge. Dtsch Ärzteblatt 108(14):243–248

    Google Scholar 

  91. Miliudin ES (2007) Evaluation of the efficiency of amnionplasty in the surgical treatment of severe ocular burn injury. Vestn Oftalmol 123:13–17

    PubMed  CAS  Google Scholar 

  92. Mochimaru H, Usui T, Yaguchi T et al (2008) Suppression of alkali burn-induced corneal neovascularization by dendritic cell vaccination targeting VEGF receptor 2. Invest Ophthalmol Vis Sci 49:2172–2177

    Article  PubMed  Google Scholar 

  93. Morgan L (1971) A new drug delivery system for the eye. Ind Med 40:11–13

    CAS  Google Scholar 

  94. Morgan S, Murray A (1996) Limbal autotransplantation in the acute and chronic phases of severe chemical injuries. Eye 10:349–354

    Article  PubMed  Google Scholar 

  95. Ozdemir O, Tekeli O, Ornek K et al (2004) Limbal autograft and allograft transplantations in patients with corneal burns. Eye 18:241–248

    Article  PubMed  CAS  Google Scholar 

  96. Pahlitzsch T, Schwartzkopf T, Knabe M (1988) Der Einfluß verschiedener nichtsteroidaler antiinflammatorischer Arzneimittel auf die corneale Wundheilung. Fortschr Ophthalmol 85:662–664

    PubMed  CAS  Google Scholar 

  97. Pattamatta U, Willcox M, Stapleton F et al (2009) Bovine lactoferrin stimulates human corneal epithelial alkali wound healing in vitro. Invest Ophthalmol Vis Sci 50:1636–1643

    Article  PubMed  Google Scholar 

  98. Pauklin M, Fuchsluger TA, Westekemper H, Steuhl KP, Meller D (2010) Midterm results of cultivated autologous and allogeneic limbal epithelial transplantation in limbal stem cell deficiency. Dev Ophthalmol 45:57–70

    Article  PubMed  Google Scholar 

  99. Perry H, Hodes L, Seedor J et al (1993) Effect of doxycycline hyclate on corneal epithelial wound healing in the rabbit alkali-burn model. Preliminary observations. Cornea 12:379–382

    Article  PubMed  CAS  Google Scholar 

  100. Pfister R, Paterson C (1980) Ascorbic acid in the treatment of alcali burns of the eye. Ophthalmology 87:1050–1057

    PubMed  CAS  Google Scholar 

  101. Pfister R (1983) Chemical injuries of the eye. Ophthalmology 90:1246–1253

    PubMed  CAS  Google Scholar 

  102. Pfister RR, Sommers CI (2006) L-Arginine-Threonine-Arginine (RTR) tetramer peptide inhibits ulceration in the alkali-injured rabbit cornea. Cornea 25:1187–1192

    Article  PubMed  Google Scholar 

  103. Pflugfelder SC, Geerling G, Kinoshita S et al (2007) DEWS Management und Therapie. The ocular surface 5. htpp://www.theocularsurface.com

  104. Pokhrel PK, Loftus SA (2007) Ocular emergencies. Am Fam Physician 76:829–836

    PubMed  Google Scholar 

  105. Prabhasawat P, Tesavibul N, Prakairungthong N, Booranapong W (2007) Efficacy of amniotic membrane patching for acute chemical and thermal ocular burns. J Med Assoc Thai 90:319–326

    PubMed  Google Scholar 

  106. Ram J, Sukhija J, Behera D, Gupta A (2010) Ocular and systemic morbidity profile in mass formic acid injuries. Ophthalmic Surg Lasers Imaging 41:123–127

    Article  PubMed  Google Scholar 

  107. Redaktion AVP (2006) Orthokin®, eine aus Eigenblut hergestellte Individualarznei. Arzneiverordnungen Praxis 33:26

    Google Scholar 

  108. Redbrake C, Buchal V (1996) Keratoplastik mit Skleraring nach schwersten Verätzungen des vorderen Augenabschnittes. Klin Monatsbl Augenheilkd 208:145–151

    Article  PubMed  CAS  Google Scholar 

  109. Rehany U, Waisman M (1994) Suppression of corneal allograft rejection by systemic cyclosporine-A in heavily vascularized rabbit corneas following alkali burns. Cornea 13:447–453

    Article  PubMed  CAS  Google Scholar 

  110. Reim M (1987) Zur Pathophysiologie und Therapie von Verätzungen. Fortschr Ophthalmol 84:65–69

    PubMed  CAS  Google Scholar 

  111. Reim M (1990) Ein neues Behandlungskonzept für schwere Verätzungen und Verbrennungen der Augen. Klin Monatsbl Augenheilkd 196:1–5

    Article  PubMed  CAS  Google Scholar 

  112. Reim M, Kuckelkorn R (1995) Verätzungen und Verbrennungen der Augen. Akt Augenheilkd 20:76–89

    Google Scholar 

  113. Renard G (2004) Physiopathology of eye burns. J Fr Ophthalmol 27:1164–1169

    Article  CAS  Google Scholar 

  114. Rieck PW, Pleyer U (2003a) Wundheilung der Hornhaut. Ophthalmologe 100:749–770

    Article  Google Scholar 

  115. Rieck PW, Pleyer U (2003b) Wundheilung der Hornhaut. Ophthalmologe 100:1109–1130

    Article  PubMed  CAS  Google Scholar 

  116. Rigal-Sastourne JC, Tixier JM, Renard JP et al (2002) Corneal burns and matrix metalloproteinases (MMP-2 and -9): the effects of human amniotic membrane transplantation. J Fr Ophthalmol 25:685–693

    CAS  Google Scholar 

  117. Rihawi S, Frentz M, Reim M, Schrage N (2005) Ist Wasser die beste Ersatzspüllösung bei Augenverätzung? Z Prakt Augenheilkd 26:440–444

    Google Scholar 

  118. Rihawi S, Frentz M, Schrage N (2006) Emergency treatment of eye burns: which rinsing solution should we choose? Graefes Arch Clin Exp Ophthalmol 244:845–854

    Article  PubMed  CAS  Google Scholar 

  119. Rihawi S, Frentz M, Reim M, Schrage NF (2008) Rinsing with isotonic saline solution for eye burns should be avoided. Burns 34:1027–1032

    Article  PubMed  Google Scholar 

  120. Risa O, Saether O, Midelfart A et al (2002) Analysis of immediate changes of water-soluble metabolites in alkali-burned rabbit cornea, a aqueous humor and lens by high-resolution 1 H-NMR spectroscopy. Graefes Arch Clin Exp Ophthalmol 240:49–55

    Article  PubMed  CAS  Google Scholar 

  121. Rochels R (1985) The role of lipid mediators in corneal inflammations. In: European Society of Ophthalmology (Congress book) Metabolic eye diseases. Yliopistopaino, Helsinki, S 379–380

  122. Roper-Hall MJ (1965) Thermal and chemical burns. Trans Ophthalmol Soc UK 85:631–653

    PubMed  CAS  Google Scholar 

  123. Said T, Dutot M, Labbe A et al (2009) Ocular burn: rinsing and healing with ionic marine solutions and vegetable oils. Ophthalmologica 223:52–59

    Article  PubMed  CAS  Google Scholar 

  124. Saika S, Yamanaka O, Okada Y et al (2007) Effect of overexpression of ppar (gamma) on the healing process of corneal alkali burn in mice. AM J Physiol Cell Physiol 293:75–86

    Article  CAS  Google Scholar 

  125. Schrage NF, Flick S, Fischern T von et al (1997) Temperaturveränderungen der Hornhaut durch Anlegen eines Augenverbandes. Ophthalmologe 94:492–495

    Article  PubMed  CAS  Google Scholar 

  126. Schrage NF, Schlossmacher B, Aschenberner W et al (2001) Phosphate buffer in alkali eye burns as an inducer of experimental corneal calcification. Burns 27:459–464

    Article  PubMed  CAS  Google Scholar 

  127. Schrage NF, Kompa S, Ballmann B et al (2005) Relationship of eye burns with calcification of the cornea? Graefes Arch Clin Exp Ophthalmol 243:780–748

    Article  PubMed  Google Scholar 

  128. Schulze F, Tost M (1967) Neue Applikatoren zur Dauertropftherapie in der Ophthalmologie und ihre Anwendungsmöglichkeiten. Klin Monatsbl Augenheilkd 151:471–477

    Google Scholar 

  129. Seedor J, Perry H, Mc Namara T et al (1987) Systemic tetracycline treatment of alkali-induced corneal ulceration in rabbits. Arch Ophthalmol 105:268–271

    PubMed  CAS  Google Scholar 

  130. Seitz B, Hayashi S, Wee WR et al (1996) In vitro effects of aminoglycolosides and fluoroquinolones on keratocytes. Invest Ophthalmol Vis Sci 37:656–665

    PubMed  CAS  Google Scholar 

  131. Seitz B, Sauer R, Hofmann-Rummelt C et al (2003) Amniontransplantation. Z Prakt Augenheilkd 24:445–450

    Google Scholar 

  132. Seitz B, Grüterich M, Cursiefen C, Kruse FE (2005) Konservative und chirurgische Therapie der neurotrophen Keratopathie. Ophthalmologe 102:15–26

    Article  PubMed  CAS  Google Scholar 

  133. Seitz B (2007) Amniontransplantation. Ophthalmologe 104:1075–1079

    Article  PubMed  CAS  Google Scholar 

  134. Sekundo W, Augustin AJ, Strempel I (2002) Topical allopurinol or corticosteroids and acetylcysteine in the early treatment of experimental corneal alkali burns: a pilot study. Eur J Ophthalmol 12:366–372

    PubMed  CAS  Google Scholar 

  135. Shahriari HA, Tokhmehchi F, Reza M, Hashemi NF (2008) Comparison of the effect of amniotic membrane suspension and autologous serum on alkaline corneal epithelial wound healing in the rabbit model. Cornea 27:1148–1150

    Article  PubMed  CAS  Google Scholar 

  136. Sharifipour F, Zamani M, Idani E, Hemmati AA (2007) Oxygen therapy for severe corneal alkali burn in rabbits. Cornea 26:1107–1110

    Article  PubMed  Google Scholar 

  137. Shimazaki J, Yang HY, Tsubota K (1997) Amniotic membrane transplantation for ocular surface reconstruction in patients with chemical and thermal burns. Ophthalmology 104:2068–2076

    PubMed  CAS  Google Scholar 

  138. Sosne G, Szliter EA, Barrett R et al (2002) Thymosin beta 4 promotes corneal wound healing and decreases inflammation in vivo following alkali injury. Exp Eye Res 74:293–299

    Article  PubMed  CAS  Google Scholar 

  139. Sosne G, Christopherson PL, Barrett RP, Fridman R (2005) Thymosin-β4 modulates corneal matrix metalloproteinase levels and polymorphonuclear cell infiltration after alkali injury. Invest Ophthalmol Vis Sci 46:2388–2395

    Article  PubMed  Google Scholar 

  140. Spector J, Fernandez WG (2008) Chemical, thermal, and biological ocular exposures. Emerg Med Clin North Am 26:125–136

    Article  PubMed  Google Scholar 

  141. Spelsberg H, Sundmacher R (2005) Die Bedeutung der frühzeitigen Aufklebung harter Kontaktlinsen in der Notfallbehandlung schwerer Alkaliverätzungen der Hornhaut (Fallbericht). Klin Monatsbl Augenheilkd 222:905–909

    Article  PubMed  CAS  Google Scholar 

  142. Spoerl E, Wollensak G, Reber F, Pillunat L (2004) Cross-Linking of human amniotic membrane by glutaraldehyde. Ophthalmic Res 36:71–77

    Article  PubMed  CAS  Google Scholar 

  143. Spöler F, Frentz M, Först M et al (2008) Analysis of hydrofluoric acid penetration and decontamination of the eye by means of time-resolved optical coherence tomography. Burns 34:549–555

    Article  PubMed  Google Scholar 

  144. Stoiber J, Muss WH, Pohla-Gubo G et al (2002) Histopathology of human corneas after amniotic membrane and limbal stem cell transplantation for severe chemical burn. Cornea 21:482–489

    Article  PubMed  Google Scholar 

  145. Stoiber J, Ruckhofer J, Muss W, Grabner G (2002) Amnion-Limbus-Transplantation zur Oberflächenrekonstruktion nach schwerer Verätzung und Verbrennung. Ophthalmologe 99:839–848

    Article  PubMed  CAS  Google Scholar 

  146. Struck HG, Franke C, Tost M, Taube C (1988) Tierexperimentelle und klinische Untersuchungen zum Einsatz von Antiphlogistika bei Verätzungen des Auges. Klin Monatsbl Augenheilkd 193:401–406

    Article  PubMed  CAS  Google Scholar 

  147. Struck HG, Geiser H, Taube C et al (1991) Zur antiphlogistischen Wirksamkeit des Ginkgolids BN 52021 bei der Verätzung des Kaninchenauges. Klin Monatsbl Augenheilkd 199:278–282

    Article  PubMed  CAS  Google Scholar 

  148. Struck HG, Geiser H, Block HU et al (1991) Leukotriene antagonist S 872 419 A for early – phase treatment of chemical burn in the rabbit eye. Eur J Ophthalmol 1:137–141

    PubMed  CAS  Google Scholar 

  149. Struck HG, Gießler S, Gießler C et al (1993) Influence of nonsteroidal drugs on ocular inflammation induced by chemical burn of the rabbit eye. In: Demouchamps JP, Verougstraete C, Caspers L-Velu, Tassignon MJS (Hrsg) Recent advances in uveitis. Kugler Publications, Amsterdam NewYork, S 581–584

  150. Struck HG, Zimmer R (1995) Morbiditätswandel bei Augenverletzungen. Med-Report 19:6

  151. Struck HG, Giessler S, Giessler C (1995) Zum Einfluß nichtsteroidaler Antiphlogistika auf die Entzündungsreaktion. Ophthalmologe 92:849–853

    PubMed  CAS  Google Scholar 

  152. Struck HG, Giessler S (1998) Treatment of ocular inflammation by inhibition of leucotriene activity. In: Diestelhorst M (Hrsg) Prostaglandins in ophthalmology. Kaden, Heidelberg, S 69–75

  153. Struck HG (2008) Therapie von Verätzungen und Verbrennungen der Augen. Klin Monatsbl Augenheilkd 225:R183–R198

    Article  PubMed  CAS  Google Scholar 

  154. Tan B (1970) Oklahoma eye irrigation tube. Trans Am Acad Ophthalmol Otolaryngol 74:435–437

    PubMed  CAS  Google Scholar 

  155. Terzidou C, Georgiadis N (1997) A simple ocular irrigation system for alkaline burns of the eye. Ophthalmic Surg Lasers 28:255–257

    PubMed  CAS  Google Scholar 

  156. Thiel R (1965) Behandlung von Verätzungen. Klin Monatsbl Augenheilkd 146:581–587

    PubMed  CAS  Google Scholar 

  157. Tripathi BJ, Tripathi RC (1989) Cytotoxic effects of benzalkonium chloride and chlorobutanol on human corneal epithelial cells in vitro. Lens Eye Toxic Res 6:395–403

    PubMed  CAS  Google Scholar 

  158. Tsai RJ, Li L, Chen J (2000) Reconstruction of damaged corneas by transplantation of autologous limbal epithelial cells. N Engl J Med 343:86–93

    Article  PubMed  CAS  Google Scholar 

  159. Tseng SC, Prabhasawat P, Barton K et al (1998) Amniotic membrane transplantation with or without limbal allografts for corneal surface reconstruction in patients with limbal stem cell deficiency. Arch Ophthalmol 116:431–441

    PubMed  CAS  Google Scholar 

  160. Tseng SC, Di Pascuale MA, Liu DT et al (2005) Intraoperative mitomycin C and amniotic membrane transplantation for fornix reconstruction in severe cicatricial ocular surface diseases. Ophthalmology 112:896–903

    Article  PubMed  Google Scholar 

  161. Tost F, Hübner D, Clemens S (2002) Erfahrungen mit der „biologischen Verbandslinse“. Kongressausgabe 100. Kongress der DOG 09:10

    Google Scholar 

  162. Tost M, Seewald E (1961) Beitrag zur konservativen Therapie von Augenverätzungen. Klin Monatsbl Augenheilkd 139:377–385

    CAS  Google Scholar 

  163. Treumer F, Flöhr C, Klettner A et al (2010) Expression von Matrixmetalloproteinase 19 in der humanen Kornea. Ophthalmologe 107:647–653

    Article  PubMed  CAS  Google Scholar 

  164. Ucakhan OO, Koklu G, Firat E (2002) Nonpreserved human amniotic membrane transplantation in acute and chronic chemical eye injuries. Cornea 21:169–172

    Article  PubMed  Google Scholar 

  165. Ueno, Mlyons BL, Burzenski LM et al (2005) Accelerated wound healing of alkali-burned corneas in MRL is associated with a reduced inflammatory signature. Invest Ophthalmol Vis Sci 46:4097–4106

    Article  PubMed  Google Scholar 

  166. Uusitalo H et al (2010) Switching from a preserved to a preservative-free prostaglandin preparation in topical glaucoma medication. Acta Ophthalmol 88:329–336

    PubMed  CAS  Google Scholar 

  167. Van Loey NE, Van Son MJ (2003) Psychopathology and psychological problems in patients with burn scars: epidemiology and management. Am J Clin Dermatol 4:245–272

    Article  Google Scholar 

  168. Watz H, Reim M (1973) Aus der Unfallstatistik einer ländlichen Augenklinik. Klin Monatsbl Augenheilkd 162:648–655

    PubMed  CAS  Google Scholar 

  169. Wenkel H, Rummelt V, Naumann GOH (1997) Autologe Nasenschleimhauttransplantation frühzeitig nach schwersten Verätzungen. Ophthalmologe 94:104–108

    Article  PubMed  CAS  Google Scholar 

  170. White CE, Park MS, Renz EM et al (2007) Burn center treatment of patients with severe anhydrous ammonia injury: case reports and literature review. J Burn Care Res 28:922–928

    Article  PubMed  Google Scholar 

  171. http://www.giftinfo.uni-mainz.de

  172. Xie Y, Tan Y, Tang S (2004) Epidemiology of 377 patients with chemical burns in Guangdong province. Burns 30:569–572

    Article  PubMed  Google Scholar 

  173. Yan Y, Wang K, Zeng Y et al (2007) A bio-mathematical model of time prediction in corneal angiogenesis after alkali burn. Burns 33:511–517

    Article  PubMed  Google Scholar 

  174. Ye J, Yao K, Kim JC (2006) Mesenchymal stem cell transplantation in a rabbit corneal alkali burn model: engraftment and involvement in wound healing. Eye 20:482–490

    Article  PubMed  CAS  Google Scholar 

  175. Yoeruek E, Ziemssen F, Henke-Fahle S et al (2008) Safety, penetration and efficacy of topically applied bevacizumab: evaluation of eyedrops in corneal neovascularization after chemical burn. Acta Ophthalmol 86:322–328

    Article  PubMed  Google Scholar 

  176. Zagelbaum B, Tostanowski J, Kerner D et al (1993) Urban eye trauma. Ophthalmology 100:851–856

    PubMed  CAS  Google Scholar 

  177. Zhang Z, Ma J, Gao G et al (2005) Plasminogen kringle 5 inhibits alkali-burn-induced corneal neovascularization. Invest Ophthalmol Vis Sci 46:4062–4071

    Article  PubMed  Google Scholar 

  178. Zhao B, Ma A, Martin FL, Fullwood NJ (2009) An investigation into corneal alkali burns using an organ culture model. Cornea 28:541–546

    Article  PubMed  CAS  Google Scholar 

  179. Zhou N, Ma P, Li DQ, Pflugfelder SC (2009) Azithromycin suppresses pro-inflammatory mediators stimulated by a TLR2 Ligand Zymosan in human corneal epithelial cells. ARVO, E-Abstract 5545/A516

Download references

Interessenkonflikt

Der korrespondierende Autor gibt an, dass kein Interessenkonflikt besteht.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to H.G. Struck.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Struck, H., Schrage, N. Verätzungen und Verbrennungen des Auges. Ophthalmologe 108, 921–928 (2011). https://doi.org/10.1007/s00347-010-2250-4

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00347-010-2250-4

Schlüsselwörter

Keywords

Navigation