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Association of XRCC1 Arg399Gln and Arg194Trp polymorphisms with susceptibility to multiple autoimmune diseases: a meta-analysis

  • Genes and Disease
  • Published:
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Abstract

The role of the X-ray repair cross-complementing gene 1(XRCC1) Arg399Gln and Arg194Trp polymorphisms has been involved in the investigations of susceptibility to multiple autoimmune diseases, but the results were inconsistent. Here, we have performed a meta-analysis to clarify the relationship between them. All appropriate case–control studies were searched in the PubMed, EMBASE and Chinese National Knowledge Infrastructure (CNKI) database. A meta-analysis was conducted on the association between the XRCC1 two polymorphisms (Arg399Gln, Arg194Trp) and risk of autoimmune diseases. Pooled odds ratios (OR) with 95% confidence intervals (CI) were conducted to assess the association. Fourteen relevant studies with a total of 2886 cases and 3257 controls were analyzed in our research. Analysis for the XRCC1 Arg399Gln polymorphism under recessive model (OR 1.53, 95% CI 1.07–2.18, P = 0.019), dominant model (OR 1.36, 95% CI 1.04–1.77, P = 0.026) and homozygous model (OR 1.67, 95% CI 1.07–2.62, P = 0.024) indicated an association in the overall population, as well as in Caucasian populations under the recessive model (OR 1.73, 95% CI 1.03–2.91, P = 0.039) and Asian populations under dominant model (OR 1.31, 95% CI 1.02–1.70, P = 0.037). Stratification by disease indicated significant association between XRCC1 Arg399Gln and rheumatoid arthritis (RA) in all genetic models (P < 0.05). However, there was no significant association between XRCC1 Arg194Trp polymorphism and autoimmune diseases in different genetic models. The current meta-analysis demonstrates that the XRCC1 Arg399Gln polymorphism confers susceptibility to autoimmune diseases in Asians and Caucasians and, in particular, shows that XRCC1 Arg399Gln polymorphism is associated with RA.

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Authors contributions

MP and XZ contributed to conception and design of the study, acquisition and interpretation of data, drafting the article and final approval of the version to be published. XD and LW helped in acquisition of data, analysis and interpretation of data, revising the article and final approval of the version to be published. YZ, TZ and XS contributed to drafting and revising the article, and final approval of the version to be published.

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    1. Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Key Laboratory of Laboratory Medicine of Henan Province, No. 1, Jianshe Road, Zhengzhou, 450052, Henan, China

      Mengle Peng, Yong Zhao, Tao Zhu, Xiaoqing Shi & Dongchun Qin

    2. Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China

      Xueliang Zhou

    3. Integrated ICU, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China

      Xianfei Ding

    4. Department of Clinical Laboratory, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi, China

      Liqiang Wei

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    Peng, M., Zhou, X., Ding, X. et al. Association of XRCC1 Arg399Gln and Arg194Trp polymorphisms with susceptibility to multiple autoimmune diseases: a meta-analysis. Rheumatol Int 37, 435–444 (2017). https://doi.org/10.1007/s00296-016-3585-1

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