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Current scenario of biomedical aspect of metal-based nanoparticles on gel dosimetry

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Abstract

In past decades, the possibility of using high atomic number nanoparticle has gained interest in gel dosimetry to enhance the dose deposited in the tumor while using low radiation as well as for better imaging purposes. Sparing of healthy tissues and targeting the tumor part have become much more captivating with the help of these systems. The gel dosimetry is a the three-dimensional dosimeter for extracting the dose, which can be used along with the nanoparticles like gold, platinum, and silver, for better therapeutic efficiency for modern radiotherapy techniques. These nanoparticles of different size prepared either by chemical route or green synthesis and incorporated into the gel system respond in a different manner. Having wide applications in therapeutic field, this study reviews the use of gel dosimeters in the therapeutic procedures and also with the aid of nanoparticles so as to achieve dose enhancement. The biological activity of the various nanoparticles has been discussed.

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Acknowledgments

The authors thank their coworkers, mentioned in the references, for their intellectual and experimental contributions.

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Authors and Affiliations

  1. Medical Gel Dosimetry Laboratory, Department of Physics, School of Advanced Sciences, VIT University, Vellore, Tamil Nadu, 632014, India

    Deena Titus & E. James Jebaseelan Samuel

  2. Chemistry of Heterocycles & Natural Product Research Laboratory, Department of Chemistry, School of Advanced Sciences, VIT University, Vellore, Tamil Nadu, 632014, India

    Selvaraj Mohana Roopan

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  1. Deena Titus
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  2. E. James Jebaseelan Samuel
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  3. Selvaraj Mohana Roopan
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Correspondence to E. James Jebaseelan Samuel or Selvaraj Mohana Roopan.

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This article deals only with a review about gel dosimetry, so it does not contain any studies with animals performed by any of the authors.

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Titus, D., Samuel, E.J.J. & Mohana Roopan, S. Current scenario of biomedical aspect of metal-based nanoparticles on gel dosimetry. Appl Microbiol Biotechnol 100, 4803–4816 (2016). https://doi.org/10.1007/s00253-016-7489-5

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  • DOI: https://doi.org/10.1007/s00253-016-7489-5

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