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Tentative biosynthetic pathways of some microbial diketopiperazines

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Abstract

Cyclodipeptides and their derivatives, the diketopiperazines (DKPs), constitute a large class of natural products that exhibit various biological properties. Until recently, there are a few characterized DKP biosynthetic pathways. In all these cases, the formation of the cyclodipeptides that harbor the DKP scaffold is catalyzed either by nonribosomal peptide synthetases or by cyclodipeptide synthases. This review focuses on the DKP biosynthetic pathways and their associated molecular mechanisms.

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Acknowledgments

This work was financially supported in part by grants from the 973 program (2013CB734000), 863 Program of China (2013AA092902), Zhejiang Provincial Natural Science Foundation of China (LQ13B020004), Zhejiang Marine Biotechnology Innovation Team (2012R10029-2), Ningbo Marine Algae Biotechnology Team (2011B81007), and K.C. Wong Magna Fund in Ningbo University. L.Z. is an Awardee for the National Distinguished Young Scholar Program in China.

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  1. Key Laboratory of Applied Marine Biotechnology of the Ministry of Education, Ningbo University, Ningbo, 315211, China

    Binbin Gu, Shan He & Xiaojun Yan

  2. Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100190, China

    Lixin Zhang

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Correspondence to Shan He or Lixin Zhang.

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Gu, B., He, S., Yan, X. et al. Tentative biosynthetic pathways of some microbial diketopiperazines. Appl Microbiol Biotechnol 97, 8439–8453 (2013). https://doi.org/10.1007/s00253-013-5175-4

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