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Clinical and imaging considerations in primary immunodeficiency disorders: an update

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Abstract

Primary immunodeficiencies are a group of genetically determined disorders with diverse presentations. The purpose of this review is to provide a practical and brief description of a select number of these diseases and to discuss the important role the radiologist can have in making an early diagnosis and in detecting and following disease complications. The role of diagnostic imaging and informed performance and interpretation are vital in the diagnosis, surveillance and management of all primary immunodeficiency disorders.

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Author information

Authors and Affiliations

  1. Department of Pediatrics, University of North Carolina at Chapel Hill, 030 MacNider Hall, CB#7231, Chapel Hill, NC, 27599, USA

    Eveline Y. Wu

  2. Department of Diagnostic Radiology, Yale School of Medicine, New Haven, CT, USA

    Lauren Ehrlich

  3. Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

    Brian Handly

  4. Division of Pediatric Radiology, Duke University Medical Center, Durham, NC, USA

    Donald P. Frush

  5. Department of Pediatrics, Duke University Medical Center, Durham, NC, USA

    Rebecca H. Buckley

  6. Department of Immunology, Duke University School of Medicine, Durham, NC, USA

    Rebecca H. Buckley

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  1. Eveline Y. Wu
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  2. Lauren Ehrlich
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  3. Brian Handly
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  4. Donald P. Frush
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  5. Rebecca H. Buckley
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Correspondence to Eveline Y. Wu.

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Wu, E.Y., Ehrlich, L., Handly, B. et al. Clinical and imaging considerations in primary immunodeficiency disorders: an update. Pediatr Radiol 46, 1630–1644 (2016). https://doi.org/10.1007/s00247-016-3684-x

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  • DOI: https://doi.org/10.1007/s00247-016-3684-x

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