Abstract
Renal stone patients are generally considered to be affected with the idiopathic form of calcium nephrolithiasis. It is debated whether a comprehensive diagnostic evaluation should be performed in first stone patients. There is a substantial number of first or mildly recurrent stone formers who do not undergo any work-up to investigate stone etiology and in whom stone etiology is unknown. In this setting, the endourological approach can provide the treating physician with diagnostic information based on the presence of Randall's plaques and/or ductal plugs, thus triggering the need for further clinical investigations.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Worcester EM, Coe FL (2008) Nephrolithiasis. Prim Care 35:369–391
Coe FL, Evan A, Worcester E (2005) Kidney stone disease. J Clin Invest 115:2598–2608
Pak CY (1982) Should patients with single renal stone occurrence undergo diagnostic evaluation? J Urol 127:855–858
Croppi E, Cupisti A, Lombardi M, Marangella M, Sanseverino R, Carrano F, D’Addessi A, Drudi FM, Gambaro G, Micali S, Simeoni PG, Tasca A, Terribile M, Zattoni F, Baggio B, Bianchi G, Caudarella R, Cicerello E, Cosciani-Cunico S, D’Angelo AR, Mossetti G, Muto G, Novenne A, Prampolini M, Strazzullo P, Trinchieri A, Vezzoli G (2010) Diagnostic and therapeutic approach in patients with urinary calculi. G Ital Nefrol 27:282–289
Alexander RT, Hemmelgarn BR, Wiebe N, Bello A, Morgan C, Samuel S, Klarenbach SW, Curhan GC, Tonelli M (2012) Kidney stones and kidney function loss: a cohort study. BMJ 345:e5287
El-Zoghby ZM, Lieske JC, Foley RN, Bergstralh EJ, Li X, Melton LJ 3rd, Krambeck AE, Rule AD (2012) Urolithiasis and the risk of ESRD. Clin J Am Soc Nephrol 7:1409–1415
Caudarella R, Vescini F, Buffa A, La Manna G, Stefoni S (2004) Osteoporosis and urolithiasis. Urol Int 72(Suppl 1):17–19
Evan AP, Lingeman JE, Coe FL, Parks JH, Bledsoe SB, Shao Y, Sommer AJ, Paterson RF, Kuo RL, Grynpas M (2003) Randall’s plaque of patients with nephrolithiasis begins in basement membranes of thin loops of Henle. J Clin Invest 111:607–616
Evan AP, Coe FL, Lingeman JE, Shao Y, Sommer AJ, Bledsoe SB, Anderson JC, Worcester EM (2007) Mechanism of formation of human calcium oxalate renal stones on Randall’s plaque. Anat Rec (Hoboken) 290:1315–1323
Linnes MP, Krambeck AE, Cornell L, Williams JC Jr, Korinek M, Bergstralh EJ, Li X, Rule AD, McCollough CM, Vrtiska TJ, Lieske JC (2013) Phenotypic characterization of kidney stone formers by endoscopic and histological quantification of intrarenal calcification. Kidney Int 84:818–825
Williams JC Jr, McAteer JA (2013) Retention and growth of urinary stones: insights from imaging. J Nephrol 26:25–31
Coe FL, Evan AP, Lingeman JE, Worcester EM (2010) Plaque and deposits in nine human stone diseases. Urol Res 38:239–247
Daudon M (2004) Analysis and classification of calculi: contribution to the etiology of calculous disease. Rev Med Suisse Romand 124:445–453
Weger M, Deutschmann H, Weger W, Kotanko P, Skrabal F (1999) Incomplete renal tubular acidosis in ‘primary’ osteoporosis. Osteoporos Int 10:325–329
Conflict of interest
The authors declare no conflict of interest.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Manuel, F.P., Alessandro, D. & Giovanni, G. Randall’s plaques, plugs and the clinical workup of the renal stone patient. Urolithiasis 43 (Suppl 1), 59–61 (2015). https://doi.org/10.1007/s00240-014-0700-1
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00240-014-0700-1