Abstract
Perchlorate is a chemical pollutant that inhibits iodide uptake and may possibly impair thyroid function. Our previous study found widespread perchlorate exposure in non-pregnant, non-lactating, healthy women residing in Istanbul. The aim of this study is to assess the relative amounts of perchlorate exposure attributable to consumption of municipal water, bottled water and boxed milk available in Istanbul. Only trace levels of perchlorate were found in treated municipal water (58 % detectable, mean = 0.13 µg/L, maximum = 0.75 µg/L) and bottled water (7.4 % detectable, mean = <LOD, maximum = 0.19 µg/L). Conversely, all 30 boxed milk samples contained measurable levels of perchlorate (mean = 4.53 µg/L; maximum = 6.21 µg/L). Median perchlorate exposure attributable to water and milk (0.007 µg/kg/day) is small compared both to the reference dose (0.7 µg/kg/day) and to total perchlorate exposure (0.13 µg/kg/day) in Istanbul. Therefore, additional studies are needed to identify the major sources of perchlorate exposure in Istanbul.
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Amitai Y, Winston G, Sack J, Wasser J, Lewis M, Blount BC, Valentin-Blasini L, Fisher N, Israeli A, Leventhal A (2007) Gestational exposure to high perchlorate concentrations in drinking water and neonatal thyroxine levels. Thyroid 17:843–850. doi:10.1089/thy.2006.0336
Andersson M, Karumbunathan V, Zimmermann MB (2012) Global iodine status in 2011 and trends over the past decade. J Nutr 142:744–750. doi:10.3945/jn.111.149393
Asami M, Kosaka K, Yoshida N (2009) Occurrence of chlorate and perchlorate in bottled beverages in Japan. J Health Sci 55:549–553
Avery AA (1999) Infantile methemoglobinemia: reexamining the role of drinking water nitrates. Environ Health Perspect 107:583–586. doi:10.2307/3434401
Blount BC, Ozpinar A, Alwis KU, Caudill SP, Gillespie JR (2008) Perchlorate, nitrate, thiocyanate, and iodide levels in chicken feed, water, and eggs from three farms. J Agric Food Chem 56:10709–10715. doi:10.1021/Jf8018326
Blount BC, Alwis KU, Jain RB, Solomon BL, Morrow JC, Jackson WA (2010) Perchlorate, nitrate, and iodide intake through tap water. Environ Sci Technol 44:9564–9570. doi:10.1021/es1025195
Braverman LE, Utiger RD (2000) Introduction to hypothyroidism. In: Braverman LE, Utiger RD (eds) Werner & Ingbar’s the thyroid: a fundamental and clinical text, 8th edn. Lippincott Williams & Wilkins, Philadelphia, pp 719–720
Capuco AV, Rice CP, Baldwin RL 6th, Bannerman DD, Paape MJ, Hare WR, Kauf AC, McCarty GW, Hapeman CJ, Sadeghi AM, Starr JL, McConnell LL, Van Tassell CP (2005) Fate of dietary perchlorate in lactating dairy cows: relevance to animal health and levels in the milk supply. Proc Natl Acad Sci 102:16152–16157. doi:10.1073/pnas.0508337102
Dasgupta PK, Martinelango PK, Jackson WA, Anderson TA, Tian K, Tock RW, Rajagopalan S (2005) The origin of naturally occurring perchlorate: the role of atmospheric processes. Environ Sci Technol 39:1569–1575
Dyke JV, Ito K, Obitsu T, Hisamatsu Y, Dasgupta PK, Blount BC (2007) Perchlorate in dairy milk. Comparison of Japan versus the United States. Environ Sci Technol 41:88–92. doi:10.1021/Es061429e
Ellington JJ, Wolfe NL, Garrison AW, Evans JJ, Avants JK, Teng Q (2001) Determination of perchlorate in tobacco plants and tobacco products. Environ Sci Technol 35:3213–3218. doi:10.1021/es0106321
Erdemgil Y, Gözet T, Can Ö, Ünsal İ, Özpınar A (2016) Perchlorate levels found in tap water collected from several cities in Turkey. Environ Monit Assess 188:158. doi:10.1007/s10661-016-5161-2
Erdoğan MF, Ağbaht K, Altunsu T, Ozbaş S, Yücesan F, Tezel B, Sargin C, Ilbeğ I, Artik N, Köse R, Erdoğan G (2009) Current iodine status in Turkey. J Endocrinol Invest 32:617–622. doi:10.1007/BF03346519
Gatseva P, Vladeva S, Argirova M (2007) Evaluation of endemic goiter prevalence in Bulgarian schoolchildren—results from national strategies for prevention and control of iodine-deficiency disorders. Biol Trace Elem Res 116:273–278
Guruge KS, Wu Q, Kannan K (2011) Occurrence and exposure assessment of perchlorate, iodide and nitrate ions from dairy milk and water in Japan and Sri Lanka. J Environ Monit 13:2312–2320
Ha W, Suarez DL, Lesch SM (2011) Perchlorate uptake in spinach as related to perchlorate, nitrate, and chloride concentrations in irrigation water. Environ Sci Technol 45:9363–9371. doi:10.1021/es2010094
Her N, Jeong H, Kim J, Yoon Y (2011) Occurrence of perchlorate in drinking water and seawater in South Korea. Arch Environ Contam Toxicol 61:166–172. doi:10.1007/s00244-010-9616-0
Hetzel BS (1983) Iodine deficiency disorders (IDD) and their eradication. Lancet 2:1126–1129
Huber DR, Blount BC, Mage DT, Letkiewicz FJ, Kumar A, Allen RH (2011) Estimating perchlorate exposure from food and tap water based on US biomonitoring and occurrence data. J Exposure Sci Environ Epidemiol 21:395–407. doi:10.1038/jes.2010.31
Industrial Database (2014) The Union of Chambers and Commodity Exchanges of Turkey (TOBB). http://sanayi.tobb.org.tr/. Accessed 20.05.2013
Kang N, Jackson WA, Dasgupta PK, Anderson TA (2008) Perchlorate production by ozone oxidation of chloride in aqueous and dry systems. Sci Total Environ 405:301–309. doi:10.1016/j.scitotenv.2008.07.010
Kirk AB, Martinelango PK, Tian K, Dutta A, Smith EE, Dasgupta PK (2005) Perchlorate and iodide in dairy and breast milk. Environ Sci Technol 39:2011–2017. doi:10.1021/Es048118t
Kirk AB, Dyke JV, Ohira S-I, Dasgupta PK (2013) Relative source contributions for perchlorate exposures in a lactating human cohort. Sci Total Environ 443:939–943. doi:10.1016/j.scitotenv.2012.11.072
Kucharzyk KH, Crawford RL, Cosens B, Hess TF (2009) Development of drinking water standards for perchlorate in the United States. J Environ Manage 91:303–310. doi:10.1016/j.jenvman.2009.09.023
Kut A, Gursoy A, Senbayram S, Bayraktar N, Budakoglu II, Akgun HS (2010) Iodine intake is still inadequate among pregnant women eight years after mandatory iodination of salt in Turkey. J Endocrinol Invest 33:461–464. doi:10.3275/6767
Kutlu AO, Kara C (2012) Iodine deficiency in pregnant women in the apparently iodine-sufficient capital city of Turkey. Clin Endocrinol 77:615–620
Laurberg P, Nøhr SB, Pedersen KM, Hreidarsson AB, Andersen S, Bülow Pedersen I, Knudsen N, Perrild H, Jørgensen T, Ovesen L (2000) Thyroid disorders in mild iodine deficiency. Thyroid 10:951–963. doi:10.1089/thy.2000.10.951
Laurberg P, Nohr SB, Pedersen KM, Fuglsang E (2004) Iodine nutrition in breast-fed infants is impaired by maternal smoking. J Clin Endocrinol Metab 89:181–187. doi:10.1210/jc.2003-030829
Leung AM, Pearce EN, Braverman LE (2010) Perchlorate, iodine and the thyroid. Best Pract Res Clin Endocrinol Metab 24:133–141. doi:10.1016/j.beem.2009.08.009
McLaughlin CL, Blake S, Hall T, Harman M, Kanda R, Hunt J, Rumsby PC (2011) Perchlorate in raw and drinking water sources in England and Wales. Water Environ J 25:456–465. doi:10.1111/j.1747-6593.2010.00237.x
MDEP (2004) Current regulatory limit: perchlorate. Massachusetts Department of Environmental Protection, Boston
Murray CW, Egan SK, Kim H, Beru N, Bolger PM (2008) US Food and Drug Administration’s Total Diet Study: dietary intake of perchlorate and iodine. J Exposure Sci Environ Epidemiol 18:571–580. doi:10.1038/sj.jes.7500648
Oh S-H, Lee J-W, Mandy P, Oh J-E (2011) Analysis and exposure assessment of perchlorate in Korean dairy products with LC-MS/MS. Environ Health Toxicol 26:e2011011. doi:10.5620/eht.2011.26.e2011011
Ozpinar A, Kelestimur F, Songur Y, Can O, Valentin L, Caldwell K, Arikan E, Unsal I, Serteser M, Inal T, Erdemgil Y, Coskun A, Bakirci N, Sezgin O, Blount B (2014) Iodine status in Turkish populations and exposure to iodide uptake inhibitors. PLoS One 9:e88206. doi:10.1371/journal.pone.0088206
Rao B, Anderson TA, Orris GJ, Rainwater KA, Rajagopalan S, Sandvig RM, Scanlon BR, Stonestrom DA, Walvoord MA, Jackson WA (2007) Widespread natural perchlorate in unsaturated zones of the southwest United States. Environ Sci Technol 41:4522–4528. doi:10.1021/es062853i
Rice CP, Baldwin Vi RL, Abbott LC, Hapeman CJ, Capuco AV, Le A, Bialek-Kalinski K, Bannerman DD, Hare WR, Paape MJ, McCarty GW, Kauf AC, Sadeghi AM, Starr JL, McConnell LL, Van Tassell CP (2007) Predicting perchlorate exposure in milk from concentrations in dairy feed. J Agric Food Chem 55:8806–8813. doi:10.1021/jf070953h
Sanchez CA, Krieger RI, Khandaker NR, Valentin-Blasini L, Blount BC (2006) Potential perchlorate exposure from Citrus sp. irrigated with contaminated water. Anal Chim Acta 567:33–38. doi:10.1016/j.aca.2006.02.013
Sanchez CA, Blount BC, Valentin-Blasini L, Lesch SM, Krieger RI (2008) Perchlorate in the feed-dairy continuum of the southwestern United States. J Agric Food Chem 56:5443–5450. doi:10.1021/Jf0733923
Seyfferth AL, Henderson MK, Parker DR (2008) Effects of common soil anions and pH on the uptake and accumulation of perchlorate in lettuce. Plant Soil 302:139–148. doi:10.1007/s11104-007-9461-8
Shi Y, Zhang P, Wang Y, Shi J, Cai Y, Mou S, Jiang G (2007) Perchlorate in sewage sludge, rice, bottled water and milk collected from different areas in China. Environ Int 33:955–962. doi:10.1016/j.envint.2007.05.007
Simsek O, Cetin C, Bilgin B (2005) A researh on determination of the drinking milk consuming habits and the factors affecting these habits in istanbul province. J Tekirdag Agric Fac 2:23–35
Stanbury JB, Ermans AE, Bourdoux P, Todd C, Oken E, Tonglet R, Vidor G, Braverman LE, Medeiros-Neto G (1998) Iodine-induced hyperthyroidism: occurrence and epidemiology. Thyroid 8:83–100. doi:10.1089/thy.1998.8.83
Succop PA, Clark S, Chen M, Galke W (2004) Imputation of data values that are less than a detection limit. J Occup Environ Hyg 1:436–441. doi:10.1080/15459620490462797
Urbansky ET (2002a) Perchlorate as an environmental contaminant. Environ Sci Pollut Res 9:187–192. doi:10.1065/espr2002.05.117
Urbansky ET (2002b) Perchlorate as an environmental contaminant. Environ Sci Pollut Res Int 9:187–192. doi:10.1065/espr2002.05.117
Urbansky ET, Brown SK, Magnuson ML, Kelty CA (2001) Perchlorate levels in samples of sodium nitrate fertilizer derived from Chilean caliche. Environ Pollut 112:299–302. doi:10.1016/s0269-7491(00)00132-9
USEPA (2008) Interim drinking water health advisory for perchlorate. Washington, DC
USGS (1996) Nitrate in ground waters of the US: assessing the risk. U.S. Geological Survey
Valentin-Blasini L, Blount BC, Delinsky A (2007) Quantification of iodide and sodium-iodide symporter inhibitors in human urine using ion chromatography tandem mass spectrometry. J Chromatogr A 1155:40–46. doi:10.1016/j.chroma.2007.04.014
van Grinsven HJ, Ward MH, Benjamin N, de Kok TM (2006) Does the evidence about health risks associated with nitrate ingestion warrant an increase of the nitrate standard for drinking water? Environ Health 5:26. doi:10.1186/1476-069X-5-26
WHO (2011) Nitrate and nitrite in drinking-water. Background document for preparation of WHO Guidelines for drinking-water quality. World Health Organization, Geneva
World Health Organization, International Atomic Energy Agency, Food and Agriculture Organization of the United Nations (1996) Trace elements in human nutrition and health. Geneva
Yang M, Her N (2011) Perchlorate in soybean sprouts (Glycine max L. Merr.), water dropwort (Oenanthe stolonifera DC.), and lotus (Nelumbo nucifera Gaertn.) Root in South Korea. J Agric Food Chem 59:7490–7495. doi:10.1021/jf2009638
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Can, O., Blount, B., Valentin-Blasini, L. et al. Perchlorate Exposure Through Water and Milk in Istanbul. Bull Environ Contam Toxicol 97, 439–445 (2016). https://doi.org/10.1007/s00128-016-1889-1
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DOI: https://doi.org/10.1007/s00128-016-1889-1