Erratum to: Celastrol suppresses invasion of colon and pancreatic cancer cells through the downregulation of expression of CXCR4 chemokine receptor
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- Yadav, V.R., Sung, B., Prasad, S. et al. J Mol Med (2013) 91: 407. doi:10.1007/s00109-012-0987-8
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Erratum to: J Mol Med. 2010 Dec;88(12):1243-53
CXCR4 is essential for CXCL12-induced invasion
Disruption of CXCR4 and CXCL12 interaction by selective antagonists or anti-CXCR4 antibody blocks cancer metastasis, suggesting an essential role for CXCR4. Therefore, when HCT116 cells were transfected with siRNA specific for CXCR4, it efficiently inhibited CXCL12-mediated invasion to about 31 % compared to the control condition. (Fig. 5a, b). Indeed, the CXCR4-specific siRNA reduced CXCR4 protein expression (Fig. 5c).