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Synthesis of 1,2,3-triazole and isoxazole-linked pyrazole hybrids and their cytotoxic activity

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Abstract

A series of novel 1,2,3-triazole and isoxazole-linked pyrazole derivatives have been synthesized from pyrazole and triazole/isoxazole scaffolds. The synthesized congeners were evaluated for their anti-proliferative efficacy in four cancer cell lines (MCF7, HEPG2, IMR32, and HELA). Majority of the compounds demonstrated potent cytotoxic activities, among them 4k and 4l showed significant cytotoxicity in all the tested cell lines.

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Acknowledgements

N.F. thanks DST (SR/WOS-A/CS-124/2012), India for the award of fellowship. G.S. and B.V.S.R thank CSIR, India for financial support as part of XII Five Year plan programmed under title ORIGIN (CSC-0108).

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Authors and Affiliations

  1. Natural Products Chemistry Division, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad, 500007, India

    B. Madhavilatha, Narjis Fatima, Gowravaram Sabitha & B. V. Subba Reddy

  2. Center for Semiochemicals, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad, 500007, India

    J. S. Yadav

  3. Centre for Chemical biology, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad, 500007, India

    Debanjan Bhattacharjee & Nishant Jain

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  1. B. Madhavilatha
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  2. Narjis Fatima
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  3. Gowravaram Sabitha
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  4. B. V. Subba Reddy
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  5. J. S. Yadav
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  6. Debanjan Bhattacharjee
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  7. Nishant Jain
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Correspondence to Gowravaram Sabitha or B. V. Subba Reddy.

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Madhavilatha, B., Fatima, N., Sabitha, G. et al. Synthesis of 1,2,3-triazole and isoxazole-linked pyrazole hybrids and their cytotoxic activity. Med Chem Res 26, 1753–1763 (2017). https://doi.org/10.1007/s00044-017-1884-z

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  • DOI: https://doi.org/10.1007/s00044-017-1884-z

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