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Comparative enzyme inhibition study of 1-deazapurines

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Abstract

A series of nitrogen heterocycles including the derivatives of 1-deazapurines, were studied for miscellaneous enzyme inhibition activities in search of the potent enzyme inhibitor. The hyperactive enzymes like carbonic anhydrase-II, phosphodiesterase-I, xanthine oxidase, α-glucosidase, and β-glucuronidase were selected for the study. The compounds 1, 2, 3, 6, 8, 11–13 and 15–17, showed significant and selective activities against different enzymes. The compounds 11 and 12 were found the most potent against carbonic anhydrase-II, α-glucosidase and β-glucuronidase in comparison to their standard compounds. These selective inhibitors can be used as lead compounds for development of drugs against various diseases associated with these enzymes.

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Acknowledgments

The authors thank Higher Education Commission Pakistan for the financial support (Grant No: PM-IPFP/HRD/HEC/2012/2794).

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Authors and Affiliations

  1. Department of Chemistry, Karakoram International University, Gilgit, 15100, Gilgit-Baltistan, Pakistan

    Iftikhar Ali & Muhammad Ismail

  2. Institut für Chemie, Universität Rostock, Albert Einstein Str. 3a, Rostock, 18059, Germany

    Iftikhar Ali, Viktor O. Iaroshenko & Peter Langer

  3. Department of Chemistry, COMSATS Institute of Information Technology, Abbottabad, 22060, Pakistan

    Ajmal Khan & Umar Farooq

  4. HEJ Research Institute of Chemistry, International Centre for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan

    Ajmal Khan, Amjad Hussain, Viqar Hyder & Viqar U. Ahmad

  5. Department of Biological Sciences and Chemistry, College of Arts and Sciences, University of Nizwa, Birkat Al-Mouz, Nizwa, 616, Sultanate of Oman

    Hidayat Hussain

  6. Leibniz-Institut für Katalyse an der Universität Rostock e.V., Albert Einstein Str. 29a, Rostock, 18059, Germany

    Peter Langer

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  1. Iftikhar Ali
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  2. Ajmal Khan
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  3. Amjad Hussain
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Correspondence to Iftikhar Ali.

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Ali, I., Khan, A., Hussain, A. et al. Comparative enzyme inhibition study of 1-deazapurines. Med Chem Res 25, 2599–2606 (2016). https://doi.org/10.1007/s00044-016-1700-1

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