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Spectroscopic characterization of novel d-amino acid-Schiff bases and their Cr(III) and Ni(II) complexes as antimicrobial agents

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Abstract

The aim of this work was to investigate the antibacterial and antifungal activities of novel d-amino acid-Schiff bases including fluorine atom and their Cr(III) and Ni(II) complexes. All these substances have been examined for antibacterial activity against pathogenic strains Listeria monocytogenes 4b ATCC19115, Staphylococcus aureus ATCC25923, Escherichia coli ATCC1280, Salmonella typhi H NCTC 901.8394, Brucella abortus (A.99, UK-1995) RSKK03026, Staphylococcus epidermis sp., Micrococus luteus ATCC9341, and Shigella dysenteria typ 10 NCTC 9351, and antifungal activity against Candida albicans Y-1200-NIH, Tokyo. The antimicrobial test results of these amino acid-Schiff base complexes exhibited better activity than some known antibiotics. In particular, diamagnetic Ni(II) complexes were more potent bactericides than all of the substances synthesized.

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Acknowledgments

This work was supported by the Gazi University Research Fund (Project number: 05/2010-03 and 05/2007-02).

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Gazi University, 06500 Tenikoklullar, Ankara, Turkey

    Nurşen Sarı, Nihat Pişkin & Nurdan Kurnaz

  2. Department of Biology, Faculty of Arts and Science, Ahi Evran University, Kırşehir, Turkey

    Hatice Öğütcü

  3. Department of Chemistry, Faculty of Science, Kırklareli University, Kırklareli, Turkey

    Nurdan Kurnaz

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  1. Nurşen Sarı
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  2. Nihat Pişkin
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  3. Hatice Öğütcü
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  4. Nurdan Kurnaz
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Correspondence to Nurşen Sarı.

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Sarı, N., Pişkin, N., Öğütcü, H. et al. Spectroscopic characterization of novel d-amino acid-Schiff bases and their Cr(III) and Ni(II) complexes as antimicrobial agents. Med Chem Res 22, 580–587 (2013). https://doi.org/10.1007/s00044-012-0039-5

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  • DOI: https://doi.org/10.1007/s00044-012-0039-5

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