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Linking GATA-3 and interleukin-13: implications in asthma

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Abstract

Introduction

Asthma is one of the serious global health problems and cause of huge mortality and morbidity. It is characterized by persistent airway inflammation, airway hyperresponsiveness, increased IgE levels and mucus hypersecretion. Asthma is mediated by dominant Th2 immune response, causing enhanced expression of Th2 cytokines. These cytokines are responsible for the various pathological changes associated with allergic asthma.

Materials and methods

The role of Th2 cells in the pathogenesis of the asthma is primarily mediated through the cytokine IL-13, also produced by type 2 innate lymphoid cells, that comes under the transcriptional regulation of GATA3. In this review we will try to explore the link between IL-13 and GATA3 in the progression and regulation of asthma and its possible role as a therapeutic target.

Conclusion

Inhibition of GATA3 activity or blockade of GATA3 expression may attenuate the interleukin-13 mediated asthma phenotypes. So, GATA3 might be a potential therapeutic target for the treatment of allergic asthma.

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Authors and Affiliations

  1. Pharmacology Division, Indian Institute of Integrative Medicine (CSIR), Jammu, India

    Sheikh Rayees & Gurdarshan Singh

  2. Experimental Breast Cancer Research Laboratory, University of Michigan, Ann Arbor, USA

    Fayaz Malik

  3. Department of Biotechnology, University of Jammu, Jammu, India

    Syed Imran Bukhari

  4. PK-PD Toxicology Division, Indian Institute of Integrative Medicine (CSIR), Canal Road, Jammu, India

    Gurdarshan Singh

Authors
  1. Sheikh Rayees
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  2. Fayaz Malik
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  3. Syed Imran Bukhari
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  4. Gurdarshan Singh
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Correspondence to Gurdarshan Singh.

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Responsible Editor: Bernhard Gibbs.

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Rayees, S., Malik, F., Bukhari, S.I. et al. Linking GATA-3 and interleukin-13: implications in asthma. Inflamm. Res. 63, 255–265 (2014). https://doi.org/10.1007/s00011-013-0700-6

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  • DOI: https://doi.org/10.1007/s00011-013-0700-6

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