Abstract
The effects of a 0.5 g/kg body weight arginine infusion on plasma inorganic phosphate and potassium were examined in 15 normal subjects, and 6 recently diagnosed insulinopenic diabetics. Plasma phosphorus displayed a highly significant (p<0.001) fall in normal subjects, with a maximum fall below the baseline of 1.11 ± 0.15 mg/100 ml or 33 ± 3% (mean ± SE). In addition, there was a highly significant correlation (p<0.01) between these falls and the insulin peaks induced by arginine. Plasma potassium levels, on the other hand, displayed a distinct and significant increase in 7 of the 8 subjects studied in this connection. The maximum increase over the baseline was 1.23 ± 0.17 meq/l or 33 ± 6% (p<0.01 ). In diabetic patients, arginine too led to a fall in phosphorus. While this was still significant, it was clearly less than in normal subjects: maximum fall = 0.64 ± 0.09 mg/100 ml or 15 ±3%. Plasma potassium increased to a greater extent than in normal subjects: maximum increase = 1.63 ± 0.21 meq/l or 42 ± 6%. These findings show that arginine is responsible for a fall in plasma phosphorus that may well be partly related to the insulin response, and an increase in plasma potassium of clinical significance, whose mechanism(s), however, are still obscure.
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Pollack H., Millet R.E., Essex H.E., Mann F.C., Bollman J.L Serum phosphate changes induced by injection of glucose into dogs under various conditions. Am. J. Physiol. 100: 117, 1934.
Forsham P.H., Thorn G.W. Changes in serum inorganic phosphorus during the intravenous glucose tolerance test as an adjunct in the diagnosis of early diabetes mellitus. Proc. Am. Diabetes Ass. 9: 101, 1949.
Gordon E.E., Graigie A., Kerr D.N.S., Cherrilk G.R., Sherlock S. Splanchnic uptake of glucose, inorganic phosphorus, and potassium after intravenous glucose load in patients with cirrhosis and in subjects without liver disease. J. Lab. Clin. Med. 55: 829, 1960.
Rabinowitz D., Zierler K.L. Forearm metabolism in obesity and its response to intraarterial insulin. Evidence for adaptive hyperinsulinism. Lancet 2: 690, 1961.
Cherrington A.D., Kawamori R., Pek S., Vranic M. Arginine infusion in dogs. Model for the role of insulin and glucagon in regulating glucose turnover and free fatty acid levels. Diabetes 23: 805, 1974.
Fiske C.H., Subbarow Y. The colorimetric determination of phosphorus. J. Biol. Chem. 46: 375, 1925.
Nichols N. The effect of glycogen deposition on liver phosphorus. J. Clin. Invest. 34: 1710, 1955.
Steele T.H. Increased urinary phosphate excretion following volume expansion in normal man. Metabolism 19: 129, 1970.
Dicherman H.W., Walker W.G. The effect of cationic amino acid infusion on potassium metabolism in vivo. Am. J. Physiol. 200: 403, 1964.
Levinsky N.G., Thyson I., Miller R.B. The relation between aminoacids and potassium in isolated rat muscle. J. Clin. Invest. 41: 480, 1962.
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Massara, F., Martelli, S., Cagliero, E. et al. The hypophosphatemia’and hyperkalemic effect of arginine in man. J Endocrinol Invest 3, 177–180 (1980). https://doi.org/10.1007/BF03348247
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DOI: https://doi.org/10.1007/BF03348247