Abstract
We evaluated somatotropic function in 142 healthy elderly subjects (54 men and 88 women), aged 60–90 years and in 10 non-professional, but regularly training elderly distance runners (7 men and 3 women), aged 60–71 years. In the healthy elderly, basal plasma growth hormone (GH) and insulin-like growth factor-I (IGF-I) median levels were 0.6 μg/L (25th and 75th centiles = 0.3, 1.3) and 100.5 μg/L (25th and 75th centiles = 63, 140), respectively. About 53% of the elderly had plasma IGF-I levels within the 3rd–97th centiles of young-adult subjects. Basal GH and IGF-I were not correlated with each other nor, with the degree of physical activity, evaluated by a self-administered questionnaire; however, basal GH showed a very weak positive correlation with age while IGF-I showed a highly significant negative correlation. The peak GH response to GHRH (1 μg/kg, iv), did not correlate with age, BMI and physical activity in 87/142 subjects investigated, but was highly correlated with basal GH levels. Correlation coefficients of plasma growth hormone binding protein (GHBP) with basal GH levels and peak GH levels following GHRH were r=-0.29 and r=-0.36, respectively, but statistical significance was not reached. In the “runners”, median values of both basal and GHRH-induced GH peak were higher than those recorded in the healthy elderly, but IGF-I levels were not significantly different and they too declined with age. These data suggest that: 1) plasma IGF-I rather than basal or stimulated GH is a better index for evaluating the effect of aging on the GH/IGF system; 2) while usual physical activity in itself does not influence somatotropic function, endurance training is related to higher basal GH levels, but fails to oppose the age-related decline of plasma IGF-I levels.
Similar content being viewed by others
References
Corpas E., Harman S.M., Blackman S.: Human growth hormone and human aging. Endocr. Rev. 14: 20–39, 1993b.
Ghigo E., Arvat E., Goffi S., Bellone J., Nicolosi M., Procopio M., Maccario M., Camanni F.: Neural control of growth hormone secretion in aged humans. In: Müller E.E., Cocchi D., Locatelli V. (Eds.), Growth Hormone and Somatomedins During Lifespan. Springer-Verlag, Berlin, 1993, pp. 275–287.
Gil-Ad I., Gurewitz R., Marcovici O., Rosenfeld J., Laron Z.: Effects of aging on human plasma growth hormone response to clonidine. Mech. Ageing Dev. 27: 97–100, 1984.
Hoffman A.R., Pyca G., Lieberman S.A., Ceda G.P., Marcus R.: The somatopause. In: Müller E.E., Cocchi D., Locatelli V. (Eds.), Growth Hormone and Somatomedins during Lifespan. Springer-Verlag, Berlin, 1993, pp. 265–274.
Zadik Z., Chalew S.A., McCarter R.J., Meistas M., Kowarski A.A.: The influence of age on the 24-hour integrated concentration of growth hormone in normal individuals. J. Clin. Endocrinol. Metab. 60: 513–516, 1985.
Vermeulen A.: Nyctohemeral growth hormone profiles in young and aged men: correlation with somatomedin-C levels. J. Clin. Endocrinol. Metab. 64: 884–888, 1987.
Van Coevorden A., Mockel J., Laurent E.: Neuroendocrine rhythms and sleep in aging men. Am. J. Physiol. 260: 251–261, 1991.
Finkelstein J.W., Roffwarg H.P., Boyar R.M., Kream J., Hellman L.: Age-related change in the twenty-four-hour spontaneous secretion of growth hormone. J. Clin. Endocrinol. Metab. 35: 665–670, 1972.
Iranmanesh A., Lizarralde G., Veldhuis J.D.: Age and relative adiposity are specific negative determinants of the frequency and amplitude of GH secretory burst and the half-life of endogenous GH in healthy men. J. Clin. Endocrinol. Metab. 73: 1081–1088, 1991.
Dudl R.J., Ensinck J.W., Palmer H.E., William R.H.: Effect of age on growth hormone secretion in man. J. Clin. Endocrinol. Metab. 37: 11–16, 1973.
Ghigo E., Goffi S., Nicolosi M., Arvat E., Bellone J., Procopio M., Valente F., Mazza E., Ghigo M.C., Camanni F.: Growth hormone (GH) responsiveness to combined administration of arginine and GH-releasing hormone does not vary with age in man. J. Clin. Endocrinol. Metab. 71: 1481–1485, 1990.
Muggeo M., Fedele D., Molinari M., Crepaldi G.: Human growth hormone and cortisol response to insulin stimulation in aging. J. Gerontol. 30: 546–551, 1975.
Rudman D., Kutner M.H., Rogers M., Lubin M.F., Fleming G.A., Bain R.P.: Impaired growth hormone secretion in the adult population. J. Clin. Invest. 67: 1361–1369, 1981.
Florini J.R., Roberts S.B.: Effect of age on blood levels of somatomedin-like growth factor. J. Gerontol. 35: 23–30, 1979.
Florini J.R., Harned J., Richman R., Weiss J.: Effect of rat age on serum levels of growth hormone and somatomedins. Mech. Ageing Dev. 15: 165–176, 1981.
Sonntag W.E., Steger R.W., Forman L.J., Meites J.: Decreased pulsatile release of growth hormone in old male rats. Endocrinology 107: 1875–1879, 1980.
Breese C.R., Ingram R.L., Sonnag W.E.: Influence of age and long-term dietary restriction on plasma insulin-like growth factor-I (IGF-I), IGF-I gene expression, and IGF-I binding proteins. J. Gerontol. 46: B180–B187, 1991.
Kahler L.W., Brief S., Westly H., Novakofski J., Bechtel P., Simon J., Walker E.: Loss of enhanced nocturnal growth hormone secretion in aging rhesus monkeys. Endocrinology 119: 1281–1284, 1986.
Clemmons D.R., Van Wyk J.J.: Factors controlling blood concentration of somatomedin-C. J. Clin. Endocrinol. Metab. 13: 113–120, 1984.
Rudman D., Axel G.F., Nagraj H.S., Gergans G.A., Lalitha P.Y., Goldberg A.F., Schlenker R.A., Cohn L., Rudman I.W., Mattson D.E.: Effects of human growth hormone in men over 60 years old. N. Engl. J. Med. 323: 1–6, 1990.
Corpas E., Harman M., Pineyro M.A., Robertson R., Blackman R.: Growth hormone (GH)-releasing hormone-(1-29) twice daily reverses the decreased GH and insulin-like growth factor-I levels in old men. J. Clin. Endocrinol. Metab. 75: 530–535, 1992.
Corpas E., Harman M., Pineyro M.A., Robertson R., Blackman R.: Continuous subcutaneous infusions of GHRH 1-44 for 14 days increase GH and IGF-I levels in old men. J. Clin. Endocrinol. Metab. 76: 134–138, 1993a.
Thompson J.L., Butterfield G.E., Marcus R.: The effects of recombinant human insulin-like growth factor-I and growth hormone on body composition in elderly women. J. Clin. Endocrinol. Metab. 80: 1845–1852, 1995.
Lamberts S.W., Vall N.K., Binnerts A.: The use of growth hormone in adults: a changing scene. Clin. Endocrinol. (Oxf.) 37: 111–115, 1992.
Daughaday W.H., Mariz I.K., Blethen S.L.: Inhibition of access of bound somatomedin to membrane receptor and immunoglobulin sites: a comparison of radioreceptor and radioimmunoassay of somatomedin in native and acid-ethanol extracted serum. J. Clin. Endocrinol. Metab. 19: 781–788, 1980.
Baumann G., Shaw M.A., Amburn K.: Regulation of plasma growth hormone-binding proteins in health and disease. Metabolism 38: 683–689, 1989.
Aaronson N.K., Acquadro C., Alonso J., Apolone G., Bucquet D., Bullinger M.: International quality of life assessment (IQOLA) project. Quality of Life Research 1: 349–351, 1992.
Ware J.J.: SF-36 Health Survey. Manual and Interpretation guide. The Health Institute, New England Medical Center. Boston, Massachusetts, 1993.
McHorney C.A., Ware J.E., Lu J.F.R., Sherbourne C.D.: The MOS 36-item short-form Health Survey (SF-36): III. Tests of data quality, scaling assumptions, and reliability across diverse patient groups. Med. Care 32: 40–66, 1994.
Ghigo E., Aimaretti G., Gianotti L., Bellone J., Arvat E., Camanni F.: New approach to the diagnosis of growth hormone deficiency in adults. Eur. J. Endocrinol. 134: 352–356, 1996.
Pohelman E.T., Copeland K.C.: Influence of physical activity on insulin-like growth factor-I in healthy younger and older men. J. Clin. Endocrinol. Metab. 71: 1468–1473, 1990.
Craig B.W.R., Brown J.E.: Effects of progressive resistance training on growth hormone and testosterone levels in young and elderly subjects. Mech. Ageing Dev. 49: 159–169, 1989.
Pyka G., Wiswell R.A., Marcus R.: Age-dependent effect of resistance exercise on growth hormone secretion in people. J. Clin. Endocrinol. Metab. 75: 404–407, 1992.
Blackman M.R.: Pituitary hormones and aging. Endocrinol. Metab. Clin. 16: 981–994, 1987.
Felicetta J.V.: The thyroid and aging. In: Sowers J.R., Felicetta J.V. (Eds.), Endocrinology of aging. Raven Press, New York, 1988, pp. 15–41.
Mariotti S., Barbesino G., Caturegli P., Bartalena L., Sansoni P., Fagnoni F., Monti D., Fagiolo U., Franceschi C., Pinchera A.: Complex alteration of thyroid function in healthy centenarians. J. Clin. Endocrinol. Metab. 77: 1130–1134, 1993.
Rodriguez-Arnao J., Miell J.P., Ross R.J.M.: Influence of thyroid hormones on the GH-IGF-I axis. Trends in Endocrinol. Metab. 4: 169–173, 1993.
Jorgensen J.O.L., Meller J., Laursen T., Orskov H., Christiansen J.S., Weeke J.: Growth hormone administration stimulates energy expenditure and extrathyroidal conversion of thyroxine to triiodothyronine in a dose-dependent manner and suppresses circadian thyrotropin levels: studies in GH-deficient adults. Clin. Endocrinol. (Oxf.) 41: 609–614, 1994.
Baumann G., Shaw M.A., Amburn K.: Circulating growth hormone binding proteins. J. Endocrinol. Invest. 17: 67–81, 1994.
Maheshwari H., Sharma L., Baumann G.: Decline of plasma growth hormone binding protein in old age. J. Clin. Endocrinol. Metab. 81: 995–997, 1996.
Author information
Authors and Affiliations
Consortia
Additional information
Contributors: M.R. Ambrosio, E.C. Degli Uberti: Chair of Endocrinology, University of Ferrara; E. Arvat, F. Camanni, E. Ghigo, L. Gianotti: Department of Clinical Pathophysiology, Division of Endocrinology, University of Torino; G. Baumann: Center for Endocrinology, Metabolism and Molecular Medicine, Northwestern Medical School, Chicago, Illinois, U.S.A.; G.P. Ceda, G. Valenti: Chair of Geriatrics, University of Parma; S.G. Cella, E.E. Müller, A. Rigamonti: Department of Medical Pharmacology, University of Milano; S. Cifani, V. Torri: Institute of Pharmacological Research “Mario Negri”, Milano; C. Corradini: Traumatologic Sport Center, Orthopedic Institute “G. Pini”, University of Milano; S. Fonzi, F. Giordano, F. Minuto, G. Murialdo, A. Polleri: Department of Endocrinology and Metabolism, University of Genova; M. Gasperi, E. Macchia, E. Martino, A. Pinchera: Institute of Endocrinology, University of Pisa; S. Ghidinelli, P. Maestri: Geriatric Institute “Pio Albergo Trivulzio”, Milano; V. Pullano: Endocrinology Service, “Mater Domini” Hospital, Catanzaro; G. Riondino, F. Strollo: Institute of Endocrinology and Metabolism, INRCA, Rome; G. Rizzi: Saluzzo Hospital, Saluzzo, Italy.
Rights and permissions
About this article
Cite this article
Italian Association for Research on Brain Aging (AIRIC) Multicenter Study Group. Function of GH/IGF-I axis in aging: Multicenter study in 152 healthy elderly subjects with different degrees of physical activity. Aging Clin Exp Res 9, 185–192 (1997). https://doi.org/10.1007/BF03340148
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF03340148