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RETRACTED ARTICLE: Effect of whole-body vibration exercise on lumbar bone mineral density, bone turnover, and chronic back pain in post-menopausal osteoporotic women treated with alendronate

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This article was retracted on 22 October 2019

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Abstract

Background and aims: Exercise may enhance the effect of alendronate on bone mineral density (BMD) and reduce chronic back pain in elderly women with osteoporosis. The aim of this study was to determine whether whole-body vibration exercise would enhance the effect of alendronate on lumbar BMD and bone turnover, and reduce chronic back pain in post-menopausal women with osteoporosis. Methods: Fifty post-menopausal women with osteoporosis, 55–88 years of age, were randomly divided into two groups of 25 patients each: one taking alendronate (5 mg daily, ALN) and one taking alendronate plus exercise (ALN+EX). Exercise consisted of whole-body vibration using a Galileo machine (Novotec, Pforzheim, Germany), at an intensity of 20 Hz, frequency once a week, and duration of exercise 4 minutes. The study lasted 12 months. Lumbar BMD was measured by dual energy X-ray absorptiometry (Hologic QDR 1500W). Urinary cross-linked N-terminal telopeptides of type I collagen (NTX) and serum alkaline phos-phatase (ALP) levels were measured by enzyme-linked immunosorbent assay and standard laboratory techniques, respectively. Chronic back pain was evaluated by face scale score at baseline and every 6 months. Results: There were no significant differences in baseline characteristics, including age, body mass index, years since menopause, lumbar BMD, urinary NTX and serum ALP levels, or face scale score between the two groups. The increase in lumbar BMD and the reduction in urinary NTX and serum ALP levels were similar in the ALN and ALN+EX groups. However, the reduction in chronic back pain was greater in the ALN+EX group than in the ALN group. Conclusions: The results of this study suggest that whole-body vibration exercise using a Galileo machine appears to be useful in reducing chronic back pain, probably by relaxing the back muscles in post-menopausal osteoporotic women treated with alendronate.

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Change history

  • 22 October 2019

    The Editor-in-Chief has retracted this article [1] because an investigation by Keio University has concluded that there are inaccuracies in the data reported.

  • 22 October 2019

    The Editor-in-Chief has retracted this article [1] because an investigation by Keio University has concluded that there are inaccuracies in the data reported.

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Authors and Affiliations

  1. Department of Sports Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan

    Jun Iwamoto MD & Tsuyoshi Takeda

  2. Department of Neurology, Mitate Hospital, Fukuoka, Japan

    Yoshihiro Sato

  3. Department of Orthopedic Surgery, Keiyu Orthopedic Hospital, Tatebayashi, Gunma, Japan

    Mitsuyoshi Uzawa

Authors
  1. Jun Iwamoto MD
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  2. Tsuyoshi Takeda
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  3. Yoshihiro Sato
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  4. Mitsuyoshi Uzawa
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Corresponding author

Correspondence to Jun Iwamoto MD.

Additional information

The Editor-in-Chief has retracted this article [1] because an investigation by Keio University has concluded that there are inaccuracies in the data reported. As this research was conducted 15 years ago the original data are not available for verification. Therefore the Editor-in-Chief no longer has confidence in this article. The investigation by Keio University also established that Yoshihiro Sato was inappropriately listed as an author on this article. Jun Iwamoto, Tsuyoshi Takeda agree with the retraction. Mitsuyoshi Uzawa has not responded to any correspondence with regards to this retraction. Yoshihiro Sato is deceased.

[1] Iwamoto, J., Takeda, T., Sato, Y. et al. Aging Clin Exp Res (2005) 17: 157. https://doi.org/10.1007/BF03324589

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Iwamoto, J., Takeda, T., Sato, Y. et al. RETRACTED ARTICLE: Effect of whole-body vibration exercise on lumbar bone mineral density, bone turnover, and chronic back pain in post-menopausal osteoporotic women treated with alendronate. Aging Clin Exp Res 17, 157–163 (2005). https://doi.org/10.1007/BF03324589

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  • DOI: https://doi.org/10.1007/BF03324589

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