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Ejaculatiestoornissen: de rol van serotonine

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Neuropraxis

Samenvatting

Zo op het eerste gezicht zijn ‘depressie’ en ‘ejaculatie’ twee termen die weinig met elkaar te maken hebben. De veelvoorkomende klacht van depressieve patiënten dat hun libido verminderd is (Matthew & Weinman, 1982) geeft echter aan dat er wel degelijk een relatie bestaat. De koppeling tussen depressies en seksueel gedrag wordt nog eens extra duidelijk uit de vele meldingen dat behandeling met antidepressiva leidt tot ejaculatieproblemen, met name tot vertraging of uitblijven van de zaadlozing (Rosen et al., 1999).

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Literatuur

  • Ahlenius, S., Larsson, K., Svensson, L., Hjorth, S., Carlsson, A., Lindberg, P., Wikstrom, H., Sanchez, D., Arvidsson, L.E., Hacksell, U. & Nilsson, J.L. (1981). Effects of a new type of 5-HT receptor agonist on male rat sexual behavior. Pharmacol Biochem Behav., 15:785-792.

    Google Scholar 

  • Ahlenius, S. & Larsson, K. (1999). Synergistic actions of the 5-HT1A receptor antagonist WAY-100635 and citalopram on male rat ejaculatory behavior. Eur.J.Pharmacol., 379:1-6.

    Google Scholar 

  • Argiolas, A. & Melis, M.R. (2004). The role of oxytocin and the paraventricular nucleus in the sexual behaviour of male mammals. Physiol Behav., 83:309-317.

    Google Scholar 

  • Bymaster, F.P., Zhang, W., Carter, P.A., Shaw, J., Chernet, E., Phebus, L., Wong, D.T. & Perry, K.W. (2002). Fluoxetine, but not other selective serotonin uptake inhibitors, increases norepinephrine and dopamine extracellular levels in prefrontal cortex. Psychopharmacology (Berl.), 160:353-361.

    Google Scholar 

  • De Jong, T.R., Pattij, T., Veening, J.G., Waldinger, M.D., Cools, A.R. & Olivier, B. (2005a). Effects of chronic selective serotonin reuptake inhibitors on 8-OH-DPAT-induced facilitation of ejaculation in rats: comparison of fluvoxamine and paroxetine. Psychopharmacology (Berl.), 179:509-515.

    Google Scholar 

  • De Jong, T.R., Pattij, T., Veening, J.G., Dederen, P.J., Waldinger, M.D., Cools, A.R. & Olivier, B. (2005b). Effects of chronic paroxetine pretreatment on (+/-)-8-hydroxy-2-(di-n-propyl-amino)tetralin induced c-fos expression following sexual behavior. Neuroscience, 134:1351-1361.

    Google Scholar 

  • Felton, T.M., Kang, T.B., Hjorth, S. & Auerbach, S.B. (2003). Effects of selective serotonin and serotonin/noradrenaline reuptake inhibitors on extracellular serotonin in rat diencephalon and frontal cortex. Naunyn Schmiedebergs Arch Pharmacol., 367:297-305.

    Google Scholar 

  • Le Poul, E., Laaris, N., Doucet, E., Laporte, A.M., Hamon, M. & Lanfumey, L. (1995). Early desensitization of somato-dendritic 5-HT1A autoreceptors in rats treated with fluoxetine or paroxetine. Naunyn Schmiedebergs Arch Pharmacol., 352:141-148.

    Google Scholar 

  • Li, Q., Muma, N.A., Battaglia, G. & Van de Kar, L.D. (1997). A desensitization of hypothalamic 5-HT1A receptors by repeated injections of paroxetine: reduction in the levels of G(i) and G(o) proteins and neuroendocrine responses, but not in the density of 5-HT1A receptors. J Pharmacol Exp Ther., 282:1581-1590.

    Google Scholar 

  • Lorrain, D.S., Matuszewich, L., Friedman, R.D. & Hull, E.M. (1997). Extracellular serotonin in the lateral hypothalamic area is increased during the postejaculatory interval and impairs copulation in male rats. J.Neurosci., 17:9361-9366.

    Google Scholar 

  • Marson, L. & McKenna, K.E. (1992). A role for 5-hydroxytryptamine in descending inhibition of spinal sexual reflexes. Exp Brain Res., 88:313-320.

    Google Scholar 

  • Mathew, R.J. & Weinman, M.L. (1982). Sexual dysfunctions in depression. Arch Sex Behav., 11:323-

    Google Scholar 

  • 328. Pattij, T., De Jong, T.R., Uitterdijk, A., Waldinger, M.D., Veening, J.G., Cools, A.R., Van der Graaf,

  • P.H. & Olivier, B. (2005). Individual differences in male rat ejaculatory behaviour: searching for models to study ejaculation disorders. Eur J Neurosci., 22:724-734.

  • Romero, L. & Artigas, F. (1997). Preferential potentiation of the effects of serotonin uptake inhibitors by 5-HT1A receptor antagonists in the dorsal raphe pathway: role of somatodendritic autoreceptors. J Neurochem., 68:2593-2603.

    Google Scholar 

  • Rosen, R.C., Lane, R.M. & Menza, M. (1999). Effects of SSRI’s on sexual function: a critical review.

  • J. Clin. Psychopharmacol., 19:67-85. Salis, P.J. & Dewsbury, D.A. (1971). p-Chlorophenylalanine facilitates copulatory behaviour in male rats. Nature, 232:400-401.

  • Waldinger, M.D., Quinn, P., Dilleen, M., Mundayat, R., Schweitzer, D.H. & Boolell, M. (2005). A multinational population survey of Intravaginal Ejaculation Latency Time. Journal of Sexual Medicine, 2:492-497.

    Google Scholar 

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Authors and Affiliations

  1. T.R. de Jong, neurobiologe, postdoc, t.r.dejong@pharm.uu.nl; Prof. dr. B. Olivier, psychofarmacoloog, Departement Farmaceutische Wetenschappen, Afdeling Psychofarmacologie, Universiteit Utrecht, Postbus 80082, 3508, Utrecht, TB

    Trynke de Jong

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de Jong, T. Ejaculatiestoornissen: de rol van serotonine. NEPR 10, 44–48 (2006). https://doi.org/10.1007/BF03079080

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