Abstract
Fifteen substituted 1,2,4-triazolo[4,3-c]quinazolines were tested for antibacterial and antifungal effects. The most effective derivatives had the triazoloquinazoline skeleton substituted with the pharmacologically active chromophores — morpholine, chlorine and nitro group. The broadest antimicrobial activity was found with 5-morpholin-4-yl-3-(5-nitrothien-2-yl)[1,2,4]triazolo[4,3-c]quinazoline in concentration of 10 mg/L forB. subtilis, 50 mg/L forS. aureus and 100 mg/L forC. tropicalis. The highest tested concentration of derivative caused 83 % growth inhibition ofR. nigricans.
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Abbreviations
- DHFR:
-
dihydrofolate reductase (EC 1.5.1.3)
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Dedicated to Professor Ján Garaj, DrSe, on the occasion of his 70 th birthday.
This work was supported by theSlovak Committee for Scientific Research VEGA, grants no. 1/1173/04, 1/0058/03 and APVT 20-007 304.
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Jantová, S., Ovádeková, R., Letašiová, S. et al. Antimicrobial activity of some substituted triazoloquinazolines. Folia Microbiol 50, 90–94 (2005). https://doi.org/10.1007/BF02931453
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DOI: https://doi.org/10.1007/BF02931453