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Theoretical study of a two-dimensional autocatalytic model for calcium dynamics at the extracellular fluid-bone interface

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Abstract

The temporal behaviours of the nonlinear substructure of a self-organized compartmental model of calcium metabolism were investigated. The order-two autocatalytic process included in this simple two-dimensional model is compared to some secondary nucleation mechanisms which should take place at the extracellular fluid-bone interface. The model gives rise to complex dynamic behaviours, and multistability properties, involving up to two stable periodic regimes (birhythmicity), were established in different topological configurations. The bifurcations occurring on the boundaries between regions of different qualitative behaviour have been determined. These properties are discussed in relation to the dynamical behaviour of other two-variable models, especially those including the same nonlinearity.

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Authors and Affiliations

  1. C.H.U. Saint-Antoine, C.N.R.S. UA 163, Service de Biophysique, 27, Rue Chaligny, 75571, Paris Cedex 12, France

    P. Tracqui, A. M. Perault-Staub, G. Milhaud & J. F. Staub

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  1. P. Tracqui
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  2. A. M. Perault-Staub
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  3. G. Milhaud
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  4. J. F. Staub
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Tracqui, P., Perault-Staub, A.M., Milhaud, G. et al. Theoretical study of a two-dimensional autocatalytic model for calcium dynamics at the extracellular fluid-bone interface. Bltn Mathcal Biology 49, 597–613 (1987). https://doi.org/10.1007/BF02460138

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  • DOI: https://doi.org/10.1007/BF02460138

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