Abstract
Tetanic hyperpolarization for theXenopus node is simulated by means of iterative solutions of the Frankenhaeuser-Huxley excitation equations together with an active transport current density term which is dependent on sodium and potassium levels as well as the ADP/ATP ratio. All time-dependent variables at the end of one interspike interval are introduced as initial conditions for the next response, whereupon all time-dependent changes in voltage and permeability factors appear identical for the third and fourth responses of a sequence. Net change in internal sodium concentration is zero throughout the third and fourth intervals if sodium loading of the system is initially adjusted to a critical level. Extent of tetanic hyperpolarization is a function of the pump conductance.
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Supported by NIH Grant No. NS08802.
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Schoepfle, G.M., Tarvin, J.T. & Martin, R.M. Simulated tetanic hyperpolarization by sodium loading of a neuronal system in which active transport is linked to the Frankenhaeuser-Huxley equations. Bltn Mathcal Biology 45, 1013–1028 (1983). https://doi.org/10.1007/BF02458828
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DOI: https://doi.org/10.1007/BF02458828